Mbp myelin basic protein [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Mbpprovided by MGI
Official Full Name: myelin basic proteinprovided by MGI
Primary source: MGI:MGI:96925
See related: Ensembl:ENSMUSG00000041607 AllianceGenome:MGI:96925
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: jve; mld; shi; Hmbpr; golli-mbp
Summary: The protein encoded by the classic Mbp gene is a major constituent of the myelin sheath of oligodendrocytes and Schwann cells in the nervous system. However, Mbp-related transcripts are also present in the bone marrow and the immune system. These mRNAs arise from the long Mbp gene (otherwise called "Golli-Mbp") that contains 3 additional exons located upstream of the classic Mbp exons. Alternative splicing from the Golli and the Mbp transcription start sites gives rise to 2 sets of Mbp-related transcripts and gene products. The Golli mRNAs contain 3 exons unique to Golli-Mbp, spliced in-frame to 1 or more Mbp exons. They encode hybrid proteins that have N-terminal Golli aa sequence linked to Mbp aa sequence. The second family of transcripts contain only Mbp exons and produce the well characterized myelin basic proteins. This complex gene structure is conserved among species suggesting that the Mbp transcription unit is an integral part of the Golli transcription unit and that this arrangement is important for the function and/or regulation of these genes. Mutation of the Mbp gene is associated with the 'shiverer' and 'myelin deficient' phenotypes in mouse. [provided by RefSeq, Jul 2008]
Expression: Biased expression in cerebellum adult (RPKM 425.3), cortex adult (RPKM 253.5) and 1 other tissue See more
Orthologs: human all
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Genomic context

Location:: 18 E3; 18 55.84 cM

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	18	NC_000084.7 (82492883..82603762)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	18	NC_000084.6 (82475091..82585637)

Chromosome 18 - NC_000084.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Involvement of Degenerating 21.5 kDa Isoform of Myelin Basic Protein in the Pathogenesis of the Relapse in Murine Relapsing-Remitting Experimental Autoimmune Encephalomyelitis and MS Autopsied Brain.
Title: Involvement of Degenerating 21.5 kDa Isoform of Myelin Basic Protein in the Pathogenesis of the Relapse in Murine Relapsing-Remitting Experimental Autoimmune Encephalomyelitis and MS Autopsied Brain.
Myelin basic protein recovery during PKU mice lifespan and the potential role of microRNAs on its regulation.
Title: Myelin basic protein recovery during PKU mice lifespan and the potential role of microRNAs on its regulation.
Developmental expression of genes involved in progesterone synthesis, metabolism and action during the post-natal cerebellar myelination.
Title: Developmental expression of genes involved in progesterone synthesis, metabolism and action during the post-natal cerebellar myelination.
Transcriptional regulators of the Golli/myelin basic protein locus integrate additive and stealth activities.
Title: Transcriptional regulators of the Golli/myelin basic protein locus integrate additive and stealth activities.
mouse MBP C8 (charge: +13) is still incorporated near cholesterol-enriched regions without SM. Thus, the highly charged C1 variant (charge: +19) needs a specific interaction with SM, whereas for C8 the incorporation at the cholesterol-rich regions is ensured due to its reduced net positive charge.
Title: Myelin basic protein (MBP) charge variants show different sphingomyelin-mediated interactions with myelin-like lipid monolayers.
In the cerebellum of the animals with antiphospholipid syndrome, it was established that the level of MBP (95-110 kDa) increased in more than 5 times (p<0.001), while the MBP (18.4 kDa) was found in very small amounts compare to the control
Title: [MIELIN BASIC PROTEIN IN THE BRAIN TISSUE OF THE BALB/C MICE WITH EXPERIMENTAL ANTIPHOSPHOLIPID SYNDROME AND AFFECTION WITH NITRIC OXIDE SYNTHESIS MODULATORS].
Myelin basic protein and the cytoplasmic domain of myelin protein zero bound and aggregated negatively charged lipid vesicles, while simultaneously folding, and both ionic strength and calcium had systematic effects on these interactions.
Title: Ionic strength and calcium regulate membrane interactions of myelin basic protein and the cytoplasmic domain of myelin protein zero.
Results support the formation of an amorphous protein phase of MBP between two membrane bilayers and provide a molecular model for major dense line formation during myelination, which is of importance when understanding myelin assembly and demyelinating conditions.
Title: Membrane Association Landscape of Myelin Basic Protein Portrays Formation of the Myelin Major Dense Line.
findings suggest that the acetylation and methylation of lysine on MBP are post-translational modifications associated with the neurological disability produced by EAE.
Title: Increased Post-Translational Lysine Acetylation of Myelin Basic Protein Is Associated with Peak Neurological Disability in a Mouse Experimental Autoimmune Encephalomyelitis Model of Multiple Sclerosis.
golli-KO mice display abnormal behavior including deficits in episodic memory and reduced anxiety.
Title: Golli Myelin Basic Proteins Modulate Voltage-Operated Ca(++) Influx and Development in Cortical and Hippocampal Neurons.

Submit: New GeneRIF Correction See all GeneRIFs (70)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Spontaneous (5) 1 citation
Targeted (4) 1 citation
Chemically induced (ENU) (1) 1 citation
Endonuclease-mediated (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Mbp (e-PCR), detects polymorphism
- UniSTS:255289

D18Nds1 (e-PCR), detects polymorphism
- UniSTS:142196

D18Mit101 (e-PCR), detects polymorphism
- UniSTS:128124

Mbp (e-PCR), detects polymorphism
- UniSTS:474755

X67319 (e-PCR)
- UniSTS:125833

C76307 (e-PCR)
- UniSTS:181153

Mbp (e-PCR), detects polymorphism
- UniSTS:259500

Mbp (e-PCR), detects polymorphism
- UniSTS:259501

D18Mit155 (e-PCR), detects polymorphism
- UniSTS:128174

Mbp (e-PCR), detects polymorphism
- UniSTS:259502

Mbp (e-PCR), detects polymorphism
- UniSTS:531420

Mbp (e-PCR), detects polymorphism
- UniSTS:143838

Mbp (e-PCR), detects polymorphism
- UniSTS:143839

Mbp (e-PCR), detects polymorphism
- UniSTS:495847

RH125203 (e-PCR)
- UniSTS:162025

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables calmodulin binding	IPI Inferred from Physical Interaction more info	PubMed
enables calmodulin binding	ISO Inferred from Sequence Orthology more info
enables lipid binding	ISO Inferred from Sequence Orthology more info
enables protease binding	IPI Inferred from Physical Interaction more info	PubMed
enables structural constituent of myelin sheath	IBA Inferred from Biological aspect of Ancestor more info
enables structural constituent of myelin sheath	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in MAPK cascade	ISO Inferred from Sequence Orthology more info
involved_in maintenance of blood-brain barrier	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within membrane organization	IDA Inferred from Direct Assay more info	PubMed
involved_in myelination	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within myelination	IDA Inferred from Direct Assay more info	PubMed
involved_in myelination	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of axonogenesis	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of heterotypic cell-cell adhesion	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of chemokine (C-X-C motif) ligand 2 production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of interleukin-6 production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of metalloendopeptidase activity	ISO Inferred from Sequence Orthology more info
involved_in response to progesterone	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within response to toxic substance	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within sensory perception of sound	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in cell periphery	IBA Inferred from Biological aspect of Ancestor more info
located_in cell periphery	IDA Inferred from Direct Assay more info	PubMed
located_in cell projection	IDA Inferred from Direct Assay more info	PubMed
located_in cell surface	ISO Inferred from Sequence Orthology more info
is_active_in compact myelin	IBA Inferred from Biological aspect of Ancestor more info
located_in compact myelin	IDA Inferred from Direct Assay more info	PubMed
located_in compact myelin	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in internode region of axon	IBA Inferred from Biological aspect of Ancestor more info
located_in internode region of axon	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in myelin sheath	HDA more info	PubMed
located_in myelin sheath	IDA Inferred from Direct Assay more info	PubMed
located_in myelin sheath	ISO Inferred from Sequence Orthology more info
is_active_in neuronal cell body	IBA Inferred from Biological aspect of Ancestor more info
located_in neuronal cell body	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
part_of protein-containing complex	IDA Inferred from Direct Assay more info	PubMed
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: myelin basic protein; Golli-Mbp

Names: myelin A1 protein; myelin deficient; shiverer

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001025245.1 → NP_001020416.1 Golli-Mbp isoform 2

See identical proteins and their annotated locations for NP_001020416.1

Status: REVIEWED

Description

Transcript Variant: This variant (8) contains 3 exons unique to Golli-Mbp and exon 1 of the classic Mbp. It encodes the shorter of the Golli-Mbp isoforms (2).

Source sequence(s)

AC117825, AK039047, AK040716

Consensus CDS

CCDS29374.1

UniProtKB/TrEMBL

Q5D096

Related

ENSMUSP00000089393.5, ENSMUST00000091789.11

Conserved Domains (1) summary

pfam01669
Location:147 → 193

Myelin_MBP; Myelin basic protein
NM_001025251.2 → NP_001020422.1 myelin basic protein isoform 1

See identical proteins and their annotated locations for NP_001020422.1

Status: REVIEWED

Description

Transcript Variant: This variant (1) encodes the longest of the classic Mbp isoforms (1).

Source sequence(s)

AC119259, BF457157, BY245551, CO425201

Consensus CDS

CCDS29376.1

UniProtKB/Swiss-Prot

P04370

Related

ENSMUSP00000121855.3, ENSMUST00000123251.9

Conserved Domains (1) summary

pfam01669
Location:14 → 194

Myelin_MBP; Myelin basic protein
NM_001025254.2 → NP_001020425.1 myelin basic protein isoform 2

See identical proteins and their annotated locations for NP_001020425.1

Status: REVIEWED

Description

Transcript Variant: This variant (2) lacks exon 5 compared to transcript variant 1 and encodes one of the classic Mbp isoforms (2) that is missing a 11 aa segment compared to isoform 1.

Source sequence(s)

BB633793, BC004704

Consensus CDS

CCDS37875.1

UniProtKB/Swiss-Prot

P04370

Related

ENSMUSP00000114630.3, ENSMUST00000153478.9

Conserved Domains (1) summary

pfam01669
Location:14 → 183

Myelin_MBP; Myelin basic protein
NM_001025255.2 → NP_001020426.1 myelin basic protein isoform 3

See identical proteins and their annotated locations for NP_001020426.1

Status: REVIEWED

Description

Transcript Variant: This variant (3) lacks exon 2 compared to transcript variant 1 and encodes one of the classic Mbp isoforms (3) that is missing a 26 aa segment compared to isoform 1.

Source sequence(s)

AC119259, BY245551, CK623660

Consensus CDS

CCDS29377.1

UniProtKB/Swiss-Prot

P04370

Related

ENSMUSP00000115082.3, ENSMUST00000142850.9

Conserved Domains (1) summary

pfam01669
Location:14 → 168

Myelin_MBP; Myelin basic protein
NM_001025256.2 → NP_001020427.1 myelin basic protein isoform 4

See identical proteins and their annotated locations for NP_001020427.1

Status: REVIEWED

Description

Transcript Variant: This variant (4) lacks exon 6 compared to transcript variant 1 and encodes one of the classic Mbp isoforms (4) that is missing a 41 aa segment compared to isoform 1.

Source sequence(s)

AC119259, AK079621, BY245551

Consensus CDS

CCDS29378.1

UniProtKB/TrEMBL

A0A498WGS3, Q542T4

Related

ENSMUSP00000115409.3, ENSMUST00000152071.9

Conserved Domains (1) summary

pfam01669
Location:14 → 148

Myelin_MBP; Myelin basic protein
NM_001025258.2 → NP_001020429.1 myelin basic protein isoform 5

See identical proteins and their annotated locations for NP_001020429.1

Status: REVIEWED

Description

Transcript Variant: This variant (5) lacks exons 2 and 5 compared to transcript variant 1 and encodes one of the classic Mbp isoforms (5) that is missing a 26 aa and a 11 aa segment compared to isoform 1.

Source sequence(s)

AC119259, BY245551, M15062

Consensus CDS

CCDS29379.1

UniProtKB/Swiss-Prot

P04370

Related

ENSMUSP00000114230.3, ENSMUST00000132369.3

Conserved Domains (1) summary

pfam01669
Location:14 → 157

Myelin_MBP; Myelin basic protein
NM_001025259.2 → NP_001020430.1 myelin basic protein isoform 6

See identical proteins and their annotated locations for NP_001020430.1

Status: REVIEWED

Description

Transcript Variant: This variant (6) lacks exons 2 and 6 compared to transcript variant 1 and encodes one of the classic Mbp isoforms (6) that is missing a 26 aa and a 41 aa segment compared to isoform 1.

Source sequence(s)

AC119259, AK005129, BY245551

Consensus CDS

CCDS89290.1

UniProtKB/TrEMBL

A0A498WGS3, Q3UGF3

Related

ENSMUSP00000116019.3, ENSMUST00000133193.9

Conserved Domains (1) summary

pfam01669
Location:14 → 122

Myelin_MBP; Myelin basic protein
NM_010777.3 → NP_034907.1 Golli-Mbp isoform 1

See identical proteins and their annotated locations for NP_034907.1

Status: REVIEWED

Description

Transcript Variant: This variant (7) contains 3 exons unique to Golli-Mbp and exons 1, 3, 4 and 7 of the classic Mbp. It encodes the longer of the Golli-Mbp isoforms (1).

Source sequence(s)

AC117825, AC119259, L07507

Consensus CDS

CCDS29373.1

UniProtKB/Swiss-Prot

P04370, Q01585, Q03139, Q03176, Q61836, Q61837, Q99KE4, Q9QWP1

UniProtKB/TrEMBL

A0A411P8U6

Related

ENSMUSP00000046185.8, ENSMUST00000047865.14

Conserved Domains (1) summary

pfam01669
Location:147 → 248

Myelin_MBP; Myelin basic protein

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000084.7 Reference GRCm39 C57BL/6J

Range

82492883..82603762

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006526452.5 → XP_006526515.1 Golli-Mbp isoform X1

UniProtKB/TrEMBL

A0A411P8U6

Conserved Domains (1) summary

pfam01669
Location:147 → 349

Myelin_MBP; Myelin basic protein
XM_006526455.3 → XP_006526518.1 Golli-Mbp isoform X5

UniProtKB/TrEMBL

A0A411P8U6

Conserved Domains (1) summary

pfam01669
Location:147 → 308

Myelin_MBP; Myelin basic protein
XM_006526453.4 → XP_006526516.1 Golli-Mbp isoform X2

UniProtKB/TrEMBL

A0A411P8U6

Conserved Domains (1) summary

pfam01669
Location:147 → 327

Myelin_MBP; Myelin basic protein
XM_006526457.4 → XP_006526520.1 Golli-Mbp isoform X8

See identical proteins and their annotated locations for XP_006526520.1

UniProtKB/TrEMBL

A0A411P8U6

Conserved Domains (1) summary

pfam01669
Location:147 → 274

Myelin_MBP; Myelin basic protein
XM_036161011.1 → XP_036016904.1 Golli-Mbp isoform X4

UniProtKB/TrEMBL

A0A411P8U6

Conserved Domains (1) summary

pfam01669
Location:147 → 317

Myelin_MBP; Myelin basic protein
XM_006526454.4 → XP_006526517.1 Golli-Mbp isoform X3

UniProtKB/TrEMBL

A0A411P8U6

Conserved Domains (1) summary

pfam01669
Location:147 → 324

Myelin_MBP; Myelin basic protein
XM_030250358.2 → XP_030106218.1 Golli-Mbp isoform X9

UniProtKB/TrEMBL

A0A411P8U6

Conserved Domains (1) summary

pfam01669
Location:147 → 282

Myelin_MBP; Myelin basic protein
XM_006526458.4 → XP_006526521.1 Golli-Mbp isoform X10

UniProtKB/TrEMBL

A0A411P8U6

Conserved Domains (1) summary

pfam01669
Location:147 → 248

Myelin_MBP; Myelin basic protein
XM_006526456.4 → XP_006526519.1 Golli-Mbp isoform X6

UniProtKB/TrEMBL

A0A411P8U6

Conserved Domains (1) summary

pfam01669
Location:147 → 301

Myelin_MBP; Myelin basic protein
XM_036161013.1 → XP_036016906.1 Golli-Mbp isoform X7

UniProtKB/TrEMBL

A0A411P8U6

Conserved Domains (1) summary

pfam01669
Location:147 → 291

Myelin_MBP; Myelin basic protein
XM_036161014.1 → XP_036016907.1 myelin basic protein isoform X11

Conserved Domains (1) summary

pfam01669
Location:14 → 217

Myelin_MBP; Myelin basic protein
XM_036161010.1 → XP_036016903.1 Golli-Mbp isoform X3

UniProtKB/TrEMBL

A0A411P8U6

Conserved Domains (1) summary

pfam01669
Location:147 → 324

Myelin_MBP; Myelin basic protein
XM_030250356.1 → XP_030106216.1 Golli-Mbp isoform X1

UniProtKB/TrEMBL

A0A411P8U6

Conserved Domains (1) summary

pfam01669
Location:147 → 349

Myelin_MBP; Myelin basic protein