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    Tnpo3 transportin 3 [ Mus musculus (house mouse) ]

    Gene ID: 320938, updated on 21-Apr-2024

    Summary

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    Official Symbol
    Tnpo3provided by MGI
    Official Full Name
    transportin 3provided by MGI
    Primary source
    MGI:MGI:1196412
    See related
    Ensembl:ENSMUSG00000012535 AllianceGenome:MGI:1196412
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Trn-SR; mKIAA4133; D6Ertd313e; 5730544L10Rik; C430013M08Rik
    Summary
    Predicted to enable identical protein binding activity and small GTPase binding activity. Predicted to be involved in protein import into nucleus. Predicted to act upstream of or within protein transport. Predicted to be located in annulate lamellae and nuclear envelope. Predicted to be active in cytoplasm. Human ortholog(s) of this gene implicated in autosomal dominant limb-girdle muscular dystrophy type 2. Orthologous to human TNPO3 (transportin 3). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 24.3), placenta adult (RPKM 20.3) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    6 A3.3; 6 12.36 cM
    Exon count:
    26
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (29540826..29609918, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (29540827..29609858, complement)

    Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene sperm microtubule inner protein 1 Neighboring gene kielin/chordin-like protein Neighboring gene predicted gene, 26627 Neighboring gene STARR-positive B cell enhancer ABC_E3647 Neighboring gene STARR-seq mESC enhancer starr_15441 Neighboring gene interferon regulatory factor 5 Neighboring gene STARR-seq mESC enhancer starr_15442 Neighboring gene CapStarr-seq enhancer MGSCv37_chr6:29559591-29559700 Neighboring gene CapStarr-seq enhancer MGSCv37_chr6:29559883-29560036 Neighboring gene STARR-seq mESC enhancer starr_15443 Neighboring gene STARR-seq mESC enhancer starr_15447 Neighboring gene STARR-positive B cell enhancer ABC_E6419 Neighboring gene STARR-seq mESC enhancer starr_15449 Neighboring gene predicted gene, 30896 Neighboring gene predicted gene, 38780

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Genetic basis for T cell recognition of a major histocompatibility complex class II-restricted neo-self peptide. Cerasoli DM, et al. J Exp Med, 1995 Nov 1. PMID 7595203, Free PMC Article
    2. A limited number of B cell lineages generates the heterogeneity of a secondary immune response. Blier PR, et al. J Immunol, 1987 Dec 15. PMID 3500977
    3. Morphological study of TNPO3 and SRSF1 interaction during myogenesis by combining confocal, structured illumination and electron microscopy analysis. Costa R, et al. Mol Cell Biochem, 2021 Apr. PMID 33452620, Free PMC Article
    4. Clonal diversity, somatic mutation, and immune memory to phosphocholine-keyhole limpet hemocyanin. Stenzel-Poore MP, et al. J Immunol, 1989 Dec 15. PMID 2512351
    5. Tnpo3 enables EBF1 function in conditions of antagonistic Notch signaling. Bayer M, et al. Genes Dev, 2022 Aug 1. PMID 36167471, Free PMC Article

    See all (32) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Tnpo3 enables EBF1 function in conditions of antagonistic Notch signaling.
      Title: Tnpo3 enables EBF1 function in conditions of antagonistic Notch signaling.
    2. Morphological study of TNPO3 and SRSF1 interaction during myogenesis by combining confocal, structured illumination and electron microscopy analysis.
      Title: Morphological study of TNPO3 and SRSF1 interaction during myogenesis by combining confocal, structured illumination and electron microscopy analysis.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (3)  1 citation
    • Chemically induced (ENU) (1) 
    • Endonuclease-mediated (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • KIAA4133, MGC90049

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables small GTPase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in protein import into nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein import into nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in annulate lamellae ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nuclear envelope ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    transportin-3
    Names
    transportin-SR

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001347079.2 → NP_001334008.1  transportin-3 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC079276
      Consensus CDS
      CCDS85023.1
      UniProtKB/TrEMBL
      Q6DI95
      Related
      ENSMUSP00000110906.2, ENSMUST00000115251.8

    2. NM_001361290.1 → NP_001348219.1  transportin-3 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC079276
      UniProtKB/TrEMBL
      Q6DI95
      Conserved Domains (1) summary
      pfam08389
      Location:54 → 182
      Xpo1; Exportin 1-like protein

    3. NM_177296.5 → NP_796270.2  transportin-3 isoform 1

      See identical proteins and their annotated locations for NP_796270.2

      Status: VALIDATED

      Source sequence(s)
      AC079276
      Consensus CDS
      CCDS19963.1
      UniProtKB/Swiss-Prot
      Q6P2B1, Q7TSL6, Q8BKX4, Q8BP42
      UniProtKB/TrEMBL
      Q6DI95
      Related
      ENSMUSP00000012679.9, ENSMUST00000012679.15
      Conserved Domains (2) summary
      smart00913
      Location:33 → 96
      IBN_N; Importin-beta N-terminal domain
      pfam08389
      Location:120 → 248
      Xpo1; Exportin 1-like protein

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000072.7 Reference GRCm39 C57BL/6J

      Range
      29540826..29609918 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006505121.5 → XP_006505184.1  transportin-3 isoform X3

      UniProtKB/TrEMBL
      Q6DI95
      Conserved Domains (1) summary
      pfam08389
      Location:55 → 182
      Xpo1; Exportin 1-like protein

    2. XM_030255468.2 → XP_030111328.1  transportin-3 isoform X1

      UniProtKB/TrEMBL
      Q6DI95
      Conserved Domains (2) summary
      smart00913
      Location:8 → 62
      IBN_N; Importin-beta N-terminal domain
      pfam08389
      Location:86 → 214
      Xpo1; Exportin 1-like protein

    3. XM_030255469.1 → XP_030111329.1  transportin-3 isoform X2

      UniProtKB/TrEMBL
      Q6DI95
      Conserved Domains (2) summary
      smart00913
      Location:8 → 62
      IBN_N; Importin-beta N-terminal domain
      pfam08389
      Location:86 → 214
      Xpo1; Exportin 1-like protein

    4. XM_030255470.1 → XP_030111330.1  transportin-3 isoform X4

      UniProtKB/TrEMBL
      Q6DI95
      Conserved Domains (1) summary
      pfam08389
      Location:54 → 182
      Xpo1; Exportin 1-like protein

    5. XM_036166242.1 → XP_036022135.1  transportin-3 isoform X3

      UniProtKB/TrEMBL
      Q6DI95
      Conserved Domains (1) summary
      pfam08389
      Location:55 → 182
      Xpo1; Exportin 1-like protein

    6. XM_036166243.1 → XP_036022136.1  transportin-3 isoform X3

      UniProtKB/TrEMBL
      Q6DI95
      Conserved Domains (1) summary
      pfam08389
      Location:55 → 182
      Xpo1; Exportin 1-like protein
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6P2B1.1 GenPept UniProtKB/Swiss-Prot:Q6P2B1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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