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    Ssu2 ssu-2 homolog [ Mus musculus (house mouse) ]

    Gene ID: 243612, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Ssu2provided by MGI
    Official Full Name
    ssu-2 homologprovided by MGI
    Primary source
    MGI:MGI:2443733
    See related
    Ensembl:ENSMUSG00000034387 AllianceGenome:MGI:2443733
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Ssuh2; Fls485; D630042P16Rik
    Summary
    Predicted to enable heat shock protein binding activity and unfolded protein binding activity. Involved in odontogenesis. Predicted to be located in cytoplasm and nucleus. Is expressed in several structures, including alimentary system; blood; brain; heart; and liver. Used to study dentin dysplasia. Orthologous to human SSUH2 (ssu-2 homolog). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in adrenal adult (RPKM 5.7), ovary adult (RPKM 3.2) and 14 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Ssu2 in Genome Data Viewer
    Location:
    6 E3; 6 52.2 cM
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (112336283..112365160, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (112359322..112388199, complement)

    Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 1700054K19 gene Neighboring gene STARR-seq mESC enhancer starr_17013 Neighboring gene STARR-seq mESC enhancer starr_17014 Neighboring gene RIKEN cDNA 5031434C07 gene Neighboring gene LIM and cysteine-rich domains 1 Neighboring gene STARR-seq mESC enhancer starr_17015 Neighboring gene predicted gene, 38873 Neighboring gene 60S ribosomal protein L23a pseudogene Neighboring gene predicted gene, 53304

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Mutation in SSUH2 Causes Autosomal-Dominant Dentin Dysplasia Type I. Xiong F, et al. Hum Mutat, 2017 Jan. PMID 27680507
    2. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article
    3. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article
    5. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (1)  1 citation
    • Endonuclease-mediated (1) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables heat shock protein binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables molecular_function ND
    No biological Data available
    more info
    		  
    enables unfolded protein binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in odontogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in odontogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    protein SSUH2 homolog
    Names
    protein ssu-2 homolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001356365.1 → NP_001343294.1  protein SSUH2 homolog isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC153594
      Conserved Domains (1) summary
      cl28246
      Location:139 → 234
      DnaJ; DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]

    2. NM_175525.3 → NP_780734.1  protein SSUH2 homolog isoform 1

      See identical proteins and their annotated locations for NP_780734.1

      Status: VALIDATED

      Source sequence(s)
      AK085578
      Consensus CDS
      CCDS20405.1
      UniProtKB/Swiss-Prot
      Q14AZ1, Q8C3L1
      Related
      ENSMUSP00000052328.6, ENSMUST00000060847.6
      Conserved Domains (1) summary
      cd10719
      Location:178 → 245
      DnaJ_zf; Zinc finger domain of DnaJ and HSP40

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000072.7 Reference GRCm39 C57BL/6J

      Range
      112336283..112365160 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017321586.1 → XP_017177075.1  protein SSUH2 homolog isoform X3

    2. XM_006506109.4 → XP_006506172.2  protein SSUH2 homolog isoform X1

      UniProtKB/TrEMBL
      A0A571BFB5
      Related
      ENSMUSP00000158856.2, ENSMUST00000238755.2
      Conserved Domains (2) summary
      COG0484
      Location:139 → 234
      DnaJ; DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]
      PRK14289
      Location:177 → 300
      PRK14289; molecular chaperone DnaJ

    3. XM_030255386.2 → XP_030111246.1  protein SSUH2 homolog isoform X2

      Conserved Domains (2) summary
      COG0484
      Location:140 → 235
      DnaJ; DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]
      PRK14289
      Location:178 → 301
      PRK14289; molecular chaperone DnaJ

    4. XM_017321588.2 → XP_017177077.1  protein SSUH2 homolog isoform X5

      Related
      ENSMUST00000143134.8
      Conserved Domains (1) summary
      PRK10767
      Location:6 → 69
      PRK10767; chaperone protein DnaJ; Provisional

    5. XM_017321587.2 → XP_017177076.1  protein SSUH2 homolog isoform X4

    RNA

    1. XR_001785133.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8C3L1.1 GenPept UniProtKB/Swiss-Prot:Q8C3L1

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