Rab11fip2 RAB11 family interacting protein 2 (class I) [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Rab11fip2provided by MGI
Official Full Name: RAB11 family interacting protein 2 (class I)provided by MGI
Primary source: MGI:MGI:1922248
See related: Ensembl:ENSMUSG00000040022 AllianceGenome:MGI:1922248
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Nrip11; 4930470G04Rik; A830046J09Rik
Summary: Predicted to enable protein homodimerization activity and protein kinase binding activity. Involved in insulin secretion involved in cellular response to glucose stimulus and regulated exocytosis. Predicted to be located in nucleoplasm. Predicted to be active in endosome and phagocytic cup. Is expressed in nephric duct of male and telencephalon ventricular layer. Orthologous to human RAB11FIP2 (RAB11 family interacting protein 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in cortex adult (RPKM 5.3), CNS E18 (RPKM 5.1) and 25 other tissues See more
Orthologs: human all
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Genomic context

Location:: 19 D3; 19 56.28 cM

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	19	NC_000085.7 (59881934..59933086, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	19	NC_000085.6 (59893502..59943656, complement)

Chromosome 19 - NC_000085.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Data demonstrate that AMPH leads to an increase of NET in endosomes of single boutons and varicosities in a Rab11-dependent manner.
Title: Rab11 supports amphetamine-stimulated norepinephrine transporter trafficking.
Rab11-FIP2 has a role in the coupling of receptor-mediated endocytosis to the subsequent sorting of receptor-containing vesicles in endosomes [RAB11-FIP2]
Title: Rab11-FIP2, an adaptor protein connecting cellular components involved in internalization and recycling of epidermal growth factor receptors.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (4)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AW558126 (e-PCR)
- UniSTS:181268

D19Mgc5 (e-PCR)
- UniSTS:256836

D19Dcr70 (e-PCR), detects polymorphism
- UniSTS:532390

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables protein homodimerization activity	ISO Inferred from Sequence Orthology more info
enables protein kinase binding	ISO Inferred from Sequence Orthology more info
enables small GTPase binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in TRAM-dependent toll-like receptor 4 signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in establishment of cell polarity	ISO Inferred from Sequence Orthology more info
involved_in insulin secretion involved in cellular response to glucose stimulus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in phagocytosis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of GTPase activity	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein localization to plasma membrane	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within protein transport	IEA Inferred from Electronic Annotation more info
involved_in regulated exocytosis	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulated exocytosis	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in endosome	IBA Inferred from Biological aspect of Ancestor more info
located_in endosome	ISO Inferred from Sequence Orthology more info
located_in intracellular membrane-bounded organelle	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in phagocytic cup	IBA Inferred from Biological aspect of Ancestor more info
located_in phagocytic cup	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: rab11 family-interacting protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001033172.3 → NP_001028344.2 rab11 family-interacting protein 2 isoform 1

See identical proteins and their annotated locations for NP_001028344.2

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the shorter transcript and encodes the longer isoform (1).

Source sequence(s)

AC105061, AC162855, BC089010

Consensus CDS

CCDS38033.1

UniProtKB/TrEMBL

Q3U366

Related

ENSMUSP00000059978.7, ENSMUST00000051996.13

Conserved Domains (2) summary

cd08682
Location:15 → 141

C2_Rab11-FIP_classI; C2 domain found in Rab11-family interacting proteins (FIP) class I

pfam09457
Location:452 → 499

RBD-FIP; FIP domain
NM_001164367.1 → NP_001157839.1 rab11 family-interacting protein 2 isoform 2

See identical proteins and their annotated locations for NP_001157839.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon, compared to variant 1. This variant also contains an alternate segment in the 3' coding region, which results in a frameshift, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.

Source sequence(s)

AC105061, AC162855, AK015534, BC089010

Consensus CDS

CCDS50482.1

UniProtKB/TrEMBL

G3UW57

Related

ENSMUSP00000128813.2, ENSMUST00000171986.8

Conserved Domains (1) summary

pfam09457
Location:310 → 357

RBD-FIP; FIP domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000085.7 Reference GRCm39 C57BL/6J

Range

59881934..59933086 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_011247386.4 → XP_011245688.1 rab11 family-interacting protein 2 isoform X1

UniProtKB/Swiss-Prot

B9EID4, G3XA57, Q5HZI0

Conserved Domains (2) summary

cd08682
Location:15 → 141

C2_Rab11-FIP_classI; C2 domain found in Rab11-family interacting proteins (FIP) class I

pfam09457
Location:452 → 499

RBD-FIP; FIP domain
XM_036161718.1 → XP_036017611.1 rab11 family-interacting protein 2 isoform X2

Conserved Domains (2) summary

pfam09457
Location:348 → 395

RBD-FIP; FIP domain

cl14603
Location:14 → 37

C2; C2 domain