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    Sec22a SEC22 homolog A, vesicle trafficking protein [ Mus musculus (house mouse) ]

    Gene ID: 317717, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Sec22aprovided by MGI
    Official Full Name
    SEC22 homolog A, vesicle trafficking proteinprovided by MGI
    Primary source
    MGI:MGI:2447876
    See related
    Ensembl:ENSMUSG00000034473 AllianceGenome:MGI:2447876
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Sec22l2; 1810005C06Rik
    Summary
    Predicted to be involved in endoplasmic reticulum to Golgi vesicle-mediated transport. Predicted to act upstream of or within protein transport and vesicle-mediated transport. Predicted to be integral component of membrane. Orthologous to human SEC22A (SEC22 homolog A, vesicle trafficking protein). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in placenta adult (RPKM 4.6), bladder adult (RPKM 4.5) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    16 B3; 16 25.21 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (35131505..35184222, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (35311131..35363929, complement)

    Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 53952 Neighboring gene 3-hydroxyacyl-CoA dehydratase 2 Neighboring gene STARR-seq mESC enhancer starr_40734 Neighboring gene adenylate cyclase 5 Neighboring gene STARR-seq mESC enhancer starr_40735 Neighboring gene predicted gene, 46550 Neighboring gene predicted gene, 25179 Neighboring gene STARR-seq mESC enhancer starr_40736 Neighboring gene STARR-seq mESC enhancer starr_40737 Neighboring gene predicted gene, 25079 Neighboring gene predicted gene, 23518

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. BioID screening of biotinylation sites using the avidin-like protein Tamavidin 2-REV identifies global interactors of stimulator of interferon genes (STING). Motani K, et al. J Biol Chem, 2020 Aug 7. PMID 32554809, Free PMC Article
    2. BayGenomics: a resource of insertional mutations in mouse embryonic stem cells. Stryke D, et al. Nucleic Acids Res, 2003 Jan 1. PMID 12520002, Free PMC Article
    3. Genome-wide expression profiling of mid-gestation placenta and embryo using a 15,000 mouse developmental cDNA microarray. Tanaka TS, et al. Proc Natl Acad Sci U S A, 2000 Aug 1. PMID 10922068, Free PMC Article
    4. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Process Evidence Code Pubs
    involved_in endoplasmic reticulum to Golgi vesicle-mediated transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in endoplasmic reticulum to Golgi vesicle-mediated transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within vesicle-mediated transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    vesicle-trafficking protein SEC22a
    Names
    SEC22 vesicle trafficking protein homolog A
    SEC22 vesicle trafficking protein homologe A
    SEC22 vesicle trafficking protein-like 2
    SEC22 vesicle trafficking protein-like A

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001418691.1 → NP_001405620.1  vesicle-trafficking protein SEC22a isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC154654

    2. NM_001418693.1 → NP_001405622.1  vesicle-trafficking protein SEC22a isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC154654

    3. NM_001418695.1 → NP_001405624.1  vesicle-trafficking protein SEC22a isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC154654
      UniProtKB/TrEMBL
      B7ZNW3
      Related
      ENSMUSP00000156164.2, ENSMUST00000232420.2

    4. NM_001418697.1 → NP_001405626.1  vesicle-trafficking protein SEC22a isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC154654

    5. NM_001418700.1 → NP_001405629.1  vesicle-trafficking protein SEC22a isoform 6

      Status: VALIDATED

      Source sequence(s)
      AC154654

    6. NM_001418701.1 → NP_001405630.1  vesicle-trafficking protein SEC22a isoform 7

      Status: VALIDATED

      Source sequence(s)
      AC154654

    7. NM_001418702.1 → NP_001405631.1  vesicle-trafficking protein SEC22a isoform 8

      Status: VALIDATED

      Source sequence(s)
      AC154654

    8. NM_001418703.1 → NP_001405632.1  vesicle-trafficking protein SEC22a isoform 9

      Status: VALIDATED

      Source sequence(s)
      AC154654

    9. NM_001418704.1 → NP_001405633.1  vesicle-trafficking protein SEC22a isoform 10

      Status: VALIDATED

      Source sequence(s)
      AC154654

    10. NM_133704.5 → NP_598465.2  vesicle-trafficking protein SEC22a isoform 1

      See identical proteins and their annotated locations for NP_598465.2

      Status: VALIDATED

      Source sequence(s)
      AC154654
      Consensus CDS
      CCDS28138.1
      UniProtKB/Swiss-Prot
      Q8BH47, Q91Z54
      UniProtKB/TrEMBL
      B2RSR2
      Related
      ENSMUSP00000039568.5, ENSMUST00000043521.5
      Conserved Domains (2) summary
      COG5143
      Location:4 → 146
      SNC1; Synaptobrevin/VAMP-like protein [Intracellular trafficking and secretion]
      pfam13774
      Location:38 → 98
      Longin; Regulated-SNARE-like domain

    RNA

    1. NR_184801.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC154654

    2. NR_184802.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC154654

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000082.7 Reference GRCm39 C57BL/6J

      Range
      35131505..35184222 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006522235.4 → XP_006522298.1  vesicle-trafficking protein SEC22a isoform X2

      Conserved Domains (1) summary
      cd14824
      Location:21 → 142
      Longin; longin domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8BH47.1 GenPept UniProtKB/Swiss-Prot:Q8BH47

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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