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    Gpnmb glycoprotein (transmembrane) nmb [ Mus musculus (house mouse) ]

    Gene ID: 93695, updated on 23-Jun-2021

    Summary

    Official Symbol
    Gpnmbprovided by MGI
    Official Full Name
    glycoprotein (transmembrane) nmbprovided by MGI
    Primary source
    MGI:MGI:1934765
    See related
    Ensembl:ENSMUSG00000029816
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Dch; ipd; DC-H; Dchil; DC-HIL
    Expression
    Biased expression in bladder adult (RPKM 24.4), genital fat pad adult (RPKM 18.0) and 8 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Gpnmb in Genome Data Viewer
    Location:
    6 B2.3; 6 23.82 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (49013449..49044413)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (49036518..49058182)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 6 NC_000072.5 (48986517..49008181)

    Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 4930563H07 gene Neighboring gene amiloride binding protein 1 (amine oxidase, copper-containing) pseudogene Neighboring gene predicted gene, 52881 Neighboring gene mitochondrial ribosomal protein S36 pseudogene Neighboring gene mitochondrial assembly of ribosomal large subunit 1 Neighboring gene predicted gene 7890

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables heparin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables heparin binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables integrin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables integrin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables receptor ligand activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables syndecan binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in cell adhesion IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acts_upstream_of_or_within cell adhesion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in cell-cell signaling ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of G1/S transition of mitotic cell cycle ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of T cell activation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of T cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of cytokine production ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of neuron death ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of tumor necrosis factor production IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of ERK1 and ERK2 cascade IC
    Inferred by Curator
    more info
    PubMed 
    involved_in positive regulation of ERK1 and ERK2 cascade IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of cell migration ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of protein autophosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of protein phosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of protein phosphorylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of tissue remodeling IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of tissue remodeling ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in signal transduction ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in cytoplasmic vesicle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in endosome IEA
    Inferred from Electronic Annotation
    more info
     
    located_in integral component of membrane ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in integral component of plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in integral component of plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    transmembrane glycoprotein NMB
    Names
    dendritic cell-associated heparin sulfate proteoglycan-dependent integrin ligand
    dendritic cell-associated transmembrane protein
    iris pigment dispersion
    osteoactivin

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_053110.4NP_444340.3  transmembrane glycoprotein NMB precursor

      See identical proteins and their annotated locations for NP_444340.3

      Status: VALIDATED

      Source sequence(s)
      AC153620, AK171465, AK171517, BY205729
      Consensus CDS
      CCDS20122.1
      UniProtKB/Swiss-Prot
      Q99P91
      Related
      ENSMUSP00000031840.8, ENSMUST00000031840.10
      Conserved Domains (1) summary
      cd00146
      Location:256316
      PKD; polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is ...

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000072.7 Reference GRCm39 C57BL/6J

      Range
      49013449..49044413
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036152412.1XP_036008305.1  transmembrane glycoprotein NMB isoform X1

      Related
      ENSMUSP00000145376.2, ENSMUST00000204260.2
      Conserved Domains (1) summary
      cd00146
      Location:256316
      PKD; polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is ...
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