Wee2 WEE1 homolog 2 (S. pombe) [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Wee2provided by MGI
Official Full Name: WEE1 homolog 2 (S. pombe)provided by MGI
Primary source: MGI:MGI:3027899
See related: Ensembl:ENSMUSG00000037159 AllianceGenome:MGI:3027899
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Wee1B; Gm1065
Summary: Predicted to enable protein tyrosine kinase activity. Involved in several processes, including female pronucleus assembly; negative regulation of oocyte maturation; and regulation of phosphorylation. Located in cytoplasm and nucleus. Is expressed in 1-cell stage embryo; olfactory epithelium; and ovary. Orthologous to human WEE2 (WEE2 oocyte meiosis inhibiting kinase). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Low expression observed in reference dataset See more
Orthologs: human all
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Genomic context

Location:: 6 B1; 6 18.82 cM

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	6	NC_000072.7 (40412180..40443749)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	6	NC_000072.6 (40435246..40466815)

Chromosome 6 - NC_000072.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

WEE1B acts as a direct downstream substrate of protein kinase A (PKA) and that Ser 15 of WEE1B is a potential PKA phosphorylation target in the G2/M transition of mouse embryos.
Title: Ser 15 of WEE1B is a potential PKA phosphorylation target in G2/M transition in one-cell stage mouse embryos.
findings demonstrate that exit from metaphase requires not only a proteolytic degradation of cyclin B but also the inhibitory phosphorylation of Cdc2 by Wee1B
Title: Protein tyrosine kinase Wee1B is essential for metaphase II exit in mouse oocytes.
Wee1B is a key maturation-promoting-factor inhibitory kinase in mouse oocytes, functions downstream of PKA, and is required for maintaining meiotic arrest.
Title: Wee1B is an oocyte-specific kinase involved in the control of meiotic arrest in the mouse.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (8) 1 citation

General gene information

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Markers

AU023319 (e-PCR)
- UniSTS:207942

NoName (e-PCR)
- UniSTS:235428

Wee2 (e-PCR), detects polymorphism
- UniSTS:526836

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables kinase activity	IEA Inferred from Electronic Annotation more info
enables magnesium ion binding	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables non-membrane spanning protein tyrosine kinase activity	IEA Inferred from Electronic Annotation more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info
enables protein kinase activity	IEA Inferred from Electronic Annotation more info
enables protein tyrosine kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein tyrosine kinase activity	TAS Traceable Author Statement more info	PubMed
enables transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in female meiotic nuclear division	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in female pronucleus assembly	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within meiotic cell cycle	IEA Inferred from Electronic Annotation more info
involved_in mitotic cell cycle	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of cyclin-dependent protein serine/threonine kinase activity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of oocyte maturation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within phosphorylation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of phosphorylation	IDA Inferred from Direct Assay more info	PubMed
involved_in protein phosphorylation	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of fertilization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of meiosis I	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of meiosis I	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: wee1-like protein kinase 2

Names: mWee1B; wee1-like protein kinase 1B; wee1B kinase

NP_958758.2

EC 2.7.10.2

XP_006506389.1

EC 2.7.10.2

XP_006506390.1

EC 2.7.10.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_201370.2 → NP_958758.2 wee1-like protein kinase 2

See identical proteins and their annotated locations for NP_958758.2

Status: VALIDATED

Source sequence(s)

AK139573, BY725757, CJ200934

Consensus CDS

CCDS20029.1

UniProtKB/Swiss-Prot

Q4U4S4, Q66JT0, Q7TPV9

Related

ENSMUSP00000038754.9, ENSMUST00000038907.9

Conserved Domains (1) summary

cl21453
Location:207 → 477

PKc_like; Protein Kinases, catalytic domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000072.7 Reference GRCm39 C57BL/6J

Range

40412180..40443749

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006506326.4 → XP_006506389.1 wee1-like protein kinase 2 isoform X1

See identical proteins and their annotated locations for XP_006506389.1

UniProtKB/Swiss-Prot

Q4U4S4, Q66JT0, Q7TPV9

Conserved Domains (1) summary

cl21453
Location:207 → 477

PKc_like; Protein Kinases, catalytic domain
XM_006506327.4 → XP_006506390.1 wee1-like protein kinase 2 isoform X2

Conserved Domains (1) summary

cl21453
Location:101 → 371

PKc_like; Protein Kinases, catalytic domain