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    Lingo1 leucine rich repeat and Ig domain containing 1 [ Mus musculus (house mouse) ]

    Gene ID: 235402, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Lingo1provided by MGI
    Official Full Name
    leucine rich repeat and Ig domain containing 1provided by MGI
    Primary source
    MGI:MGI:1915522
    See related
    Ensembl:ENSMUSG00000049556 AllianceGenome:MGI:1915522
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    LERN1; Lrrn6a; UNQ201; LINGO-1; 4930471K13Rik
    Summary
    Enables epidermal growth factor receptor binding activity. Acts upstream of or within generation of neurons and protein kinase B signaling. Predicted to be located in plasma membrane. Predicted to be integral component of membrane. Predicted to be active in extracellular matrix and extracellular space. Is expressed in several structures, including branchial arch; central nervous system; gut; sensory organ; and somite. Human ortholog(s) of this gene implicated in autosomal recessive non-syndromic intellectual disability and glaucoma. Orthologous to human LINGO1 (leucine rich repeat and Ig domain containing 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in cortex adult (RPKM 56.6), frontal lobe adult (RPKM 39.0) and 6 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Lingo1 in Genome Data Viewer
    Location:
    9 B; 9 30.28 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (56525743..56704355, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (56618460..56796310, complement)

    Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 31529 Neighboring gene predicted gene, 26868 Neighboring gene STARR-positive B cell enhancer mm9_chr9:56484136-56484437 Neighboring gene STARR-seq mESC enhancer starr_24211 Neighboring gene predicted gene, 31642 Neighboring gene predicted gene, 53525 Neighboring gene predicted gene, 31586 Neighboring gene ciliary microtubule associated protein 1C Neighboring gene chondroitin sulfate proteoglycan 4 Neighboring gene STARR-positive B cell enhancer ABC_E10548 Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:56776219-56776328 Neighboring gene sorting nexin 33

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. LINGO-1 deficiency promotes nerve regeneration through reduction of cell apoptosis, inflammation, and glial scar after spinal cord injury in mice. Huang LJ, et al. Exp Neurol, 2019 Oct. PMID 31132364
    2. Inhibition of LINGO-1 promotes functional recovery after experimental spinal cord demyelination. Zhang Y, et al. Exp Neurol, 2015 Apr. PMID 25681574
    3. Neutralization of LINGO-1 during in vitro differentiation of neural stem cells results in proliferation of immature neurons. Lööv C, et al. PLoS One, 2012. PMID 22235341, Free PMC Article
    4. LINGO-1 antagonist promotes spinal cord remyelination and axonal integrity in MOG-induced experimental autoimmune encephalomyelitis. Mi S, et al. Nat Med, 2007 Oct. PMID 17906634
    5. LINGO-1 shRNA protects the brain against ischemia/reperfusion injury by inhibiting the activation of NF-κB and JAK2/STAT3. Zhu J, et al. Hum Cell, 2021 Jul. PMID 33830473, Free PMC Article

    See all (40) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Antagonizing LINGO-1 reduces activated microglia and alleviates dendritic spine loss in the hippocampus of APP/PS1 transgenic mice.
      Title: Antagonizing LINGO-1 reduces activated microglia and alleviates dendritic spine loss in the hippocampus of APP/PS1 transgenic mice.
    2. LINGO-1 shRNA protects the brain against ischemia/reperfusion injury by inhibiting the activation of NF-kappaB and JAK2/STAT3.
      Title: LINGO-1 shRNA protects the brain against ischemia/reperfusion injury by inhibiting the activation of NF-κB and JAK2/STAT3.
    3. LINGO-1 regulates Wnt5a signaling during neural stem and progenitor cell differentiation by modulating miR-15b-3p levels.
      Title: LINGO-1 regulates Wnt5a signaling during neural stem and progenitor cell differentiation by modulating miR-15b-3p levels.
    4. results suggested that LINGO-1 plays a critical role in the injury microenvironment in processes such as cell death, inflammatory response, and glial scar formation after spinal cord injury
      Title: LINGO-1 deficiency promotes nerve regeneration through reduction of cell apoptosis, inflammation, and glial scar after spinal cord injury in mice.
    5. Myelin loss and subsequent axon degeneration contributes to a variety of neurological diseases, such as multiple sclerosis (MS).
      Title: LINGO-1 Regulates Oligodendrocyte Differentiation through the Cytoplasmic Gelsolin Signaling Pathway.
    6. These data provide morphometric and functional evidence of enhancement of remyelination associated with antagonism of LINGO-1
      Title: Inhibition of LINGO-1 promotes functional recovery after experimental spinal cord demyelination.
    7. LINGO-1, a transmembrane signaling protein, inhibits oligodendrocyte differentiation and myelination through intercellular self-interactions
      Title: LINGO-1, a transmembrane signaling protein, inhibits oligodendrocyte differentiation and myelination through intercellular self-interactions.
    8. a novel role for LINGO-1 in neural stem cell differentiation to neurons
      Title: Neutralization of LINGO-1 during in vitro differentiation of neural stem cells results in proliferation of immature neurons.
    9. Lingo1 antagonist promotes spinal cord remyelination and axonal integrity in MOG-induced experimental autoimmune encephalomyelitis.
      Title: LINGO-1 antagonist promotes spinal cord remyelination and axonal integrity in MOG-induced experimental autoimmune encephalomyelitis.
    10. inhibitory agents of LINGO-1 activity can protect dopaminergic neurons against degeneration
      Title: Inhibition of the leucine-rich repeat protein LINGO-1 enhances survival, structure, and function of dopaminergic neurons in Parkinson's disease models.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables epidermal growth factor receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables epidermal growth factor receptor binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within central nervous system neuron development IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within central nervous system neuron development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within negative regulation of oligodendrocyte differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within neuron projection development IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of oligodendrocyte differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in extracellular matrix IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in glutamatergic synapse IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in presynapse IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1
    Names
    leucine-rich repeat neuronal protein 1
    leucine-rich repeat neuronal protein 6A

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001311076.1 → NP_001298005.1  leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1 isoform 1 precursor

      See identical proteins and their annotated locations for NP_001298005.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform.
      Source sequence(s)
      AC134578, AI425964, AK034084, BC052384, BQ174824, CJ057077, CO426272
      Consensus CDS
      CCDS81004.1
      UniProtKB/TrEMBL
      A9DA50
      Related
      ENSMUSP00000109894.2, ENSMUST00000114256.2
      Conserved Domains (6) summary
      TIGR00864
      Location:341 → 421
      PCC; polycystin cation channel protein
      smart00013
      Location:41 → 75
      LRRNT; Leucine rich repeat N-terminal domain
      COG4886
      Location:66 → 371
      LRR; Leucine-rich repeat (LRR) protein [Transcription]
      sd00033
      Location:73 → 96
      LRR_RI; leucine-rich repeat [structural motif]
      pfam13855
      Location:120 → 179
      LRR_8; Leucine rich repeat
      cd20969
      Location:423 → 514
      IgI_Lingo-1; Immunoglobulin I-set domain of the Leucine-rich repeat and immunoglobin-like domain-containing protein 1 (Lingo-1)

    2. NM_001361115.1 → NP_001348044.1  leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1 isoform 2 precursor

      Status: VALIDATED

      Source sequence(s)
      AC126257, AC134578
      Consensus CDS
      CCDS23209.1
      UniProtKB/Swiss-Prot
      Q3TQJ4, Q6VVF9, Q7TT38, Q9D1T0
      Conserved Domains (6) summary
      TIGR00864
      Location:335 → 415
      PCC; polycystin cation channel protein
      smart00013
      Location:35 → 69
      LRRNT; Leucine rich repeat N-terminal domain
      COG4886
      Location:60 → 365
      LRR; Leucine-rich repeat (LRR) protein [Transcription]
      sd00033
      Location:67 → 90
      LRR_RI; leucine-rich repeat [structural motif]
      pfam13855
      Location:114 → 173
      LRR_8; Leucine rich repeat
      cd20969
      Location:417 → 508
      IgI_Lingo-1; Immunoglobulin I-set domain of the Leucine-rich repeat and immunoglobin-like domain-containing protein 1 (Lingo-1)

    3. NM_001361116.1 → NP_001348045.1  leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1 isoform 2 precursor

      Status: VALIDATED

      Source sequence(s)
      AC126257, AC134578
      Consensus CDS
      CCDS23209.1
      UniProtKB/Swiss-Prot
      Q3TQJ4, Q6VVF9, Q7TT38, Q9D1T0
      Conserved Domains (6) summary
      TIGR00864
      Location:335 → 415
      PCC; polycystin cation channel protein
      smart00013
      Location:35 → 69
      LRRNT; Leucine rich repeat N-terminal domain
      COG4886
      Location:60 → 365
      LRR; Leucine-rich repeat (LRR) protein [Transcription]
      sd00033
      Location:67 → 90
      LRR_RI; leucine-rich repeat [structural motif]
      pfam13855
      Location:114 → 173
      LRR_8; Leucine rich repeat
      cd20969
      Location:417 → 508
      IgI_Lingo-1; Immunoglobulin I-set domain of the Leucine-rich repeat and immunoglobin-like domain-containing protein 1 (Lingo-1)

    4. NM_001361117.1 → NP_001348046.1  leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1 isoform 2 precursor

      Status: VALIDATED

      Source sequence(s)
      AC126257, AC134578
      Consensus CDS
      CCDS23209.1
      UniProtKB/Swiss-Prot
      Q3TQJ4, Q6VVF9, Q7TT38, Q9D1T0
      Conserved Domains (6) summary
      TIGR00864
      Location:335 → 415
      PCC; polycystin cation channel protein
      smart00013
      Location:35 → 69
      LRRNT; Leucine rich repeat N-terminal domain
      COG4886
      Location:60 → 365
      LRR; Leucine-rich repeat (LRR) protein [Transcription]
      sd00033
      Location:67 → 90
      LRR_RI; leucine-rich repeat [structural motif]
      pfam13855
      Location:114 → 173
      LRR_8; Leucine rich repeat
      cd20969
      Location:417 → 508
      IgI_Lingo-1; Immunoglobulin I-set domain of the Leucine-rich repeat and immunoglobin-like domain-containing protein 1 (Lingo-1)

    5. NM_001361118.1 → NP_001348047.1  leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1 isoform 2 precursor

      Status: VALIDATED

      Source sequence(s)
      AC126257, AC134578
      Consensus CDS
      CCDS23209.1
      UniProtKB/Swiss-Prot
      Q3TQJ4, Q6VVF9, Q7TT38, Q9D1T0
      Related
      ENSMUSP00000059050.2, ENSMUST00000053568.2
      Conserved Domains (6) summary
      TIGR00864
      Location:335 → 415
      PCC; polycystin cation channel protein
      smart00013
      Location:35 → 69
      LRRNT; Leucine rich repeat N-terminal domain
      COG4886
      Location:60 → 365
      LRR; Leucine-rich repeat (LRR) protein [Transcription]
      sd00033
      Location:67 → 90
      LRR_RI; leucine-rich repeat [structural motif]
      pfam13855
      Location:114 → 173
      LRR_8; Leucine rich repeat
      cd20969
      Location:417 → 508
      IgI_Lingo-1; Immunoglobulin I-set domain of the Leucine-rich repeat and immunoglobin-like domain-containing protein 1 (Lingo-1)

    6. NM_001361119.1 → NP_001348048.1  leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1 isoform 2 precursor

      Status: VALIDATED

      Source sequence(s)
      AC126257, AC134578
      Consensus CDS
      CCDS23209.1
      UniProtKB/Swiss-Prot
      Q3TQJ4, Q6VVF9, Q7TT38, Q9D1T0
      Conserved Domains (6) summary
      TIGR00864
      Location:335 → 415
      PCC; polycystin cation channel protein
      smart00013
      Location:35 → 69
      LRRNT; Leucine rich repeat N-terminal domain
      COG4886
      Location:60 → 365
      LRR; Leucine-rich repeat (LRR) protein [Transcription]
      sd00033
      Location:67 → 90
      LRR_RI; leucine-rich repeat [structural motif]
      pfam13855
      Location:114 → 173
      LRR_8; Leucine rich repeat
      cd20969
      Location:417 → 508
      IgI_Lingo-1; Immunoglobulin I-set domain of the Leucine-rich repeat and immunoglobin-like domain-containing protein 1 (Lingo-1)

    7. NM_001361120.1 → NP_001348049.1  leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1 isoform 2 precursor

      Status: VALIDATED

      Source sequence(s)
      AC126257, AC134578
      Consensus CDS
      CCDS23209.1
      UniProtKB/Swiss-Prot
      Q3TQJ4, Q6VVF9, Q7TT38, Q9D1T0
      Conserved Domains (6) summary
      TIGR00864
      Location:335 → 415
      PCC; polycystin cation channel protein
      smart00013
      Location:35 → 69
      LRRNT; Leucine rich repeat N-terminal domain
      COG4886
      Location:60 → 365
      LRR; Leucine-rich repeat (LRR) protein [Transcription]
      sd00033
      Location:67 → 90
      LRR_RI; leucine-rich repeat [structural motif]
      pfam13855
      Location:114 → 173
      LRR_8; Leucine rich repeat
      cd20969
      Location:417 → 508
      IgI_Lingo-1; Immunoglobulin I-set domain of the Leucine-rich repeat and immunoglobin-like domain-containing protein 1 (Lingo-1)

    8. NM_181074.5 → NP_851419.1  leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1 isoform 2 precursor

      See identical proteins and their annotated locations for NP_851419.1

      Status: VALIDATED

      Source sequence(s)
      AC126257, AC134578
      Consensus CDS
      CCDS23209.1
      UniProtKB/Swiss-Prot
      Q3TQJ4, Q6VVF9, Q7TT38, Q9D1T0
      Related
      ENSMUSP00000148179.2, ENSMUST00000210032.2
      Conserved Domains (6) summary
      TIGR00864
      Location:335 → 415
      PCC; polycystin cation channel protein
      smart00013
      Location:35 → 69
      LRRNT; Leucine rich repeat N-terminal domain
      COG4886
      Location:60 → 365
      LRR; Leucine-rich repeat (LRR) protein [Transcription]
      sd00033
      Location:67 → 90
      LRR_RI; leucine-rich repeat [structural motif]
      pfam13855
      Location:114 → 173
      LRR_8; Leucine rich repeat
      cd20969
      Location:417 → 508
      IgI_Lingo-1; Immunoglobulin I-set domain of the Leucine-rich repeat and immunoglobin-like domain-containing protein 1 (Lingo-1)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000075.7 Reference GRCm39 C57BL/6J

      Range
      56525743..56704355 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036154897.1 → XP_036010790.1  leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1 isoform X2

      UniProtKB/Swiss-Prot
      Q3TQJ4, Q6VVF9, Q7TT38, Q9D1T0
      Conserved Domains (6) summary
      TIGR00864
      Location:335 → 415
      PCC; polycystin cation channel protein
      smart00013
      Location:35 → 69
      LRRNT; Leucine rich repeat N-terminal domain
      COG4886
      Location:60 → 365
      LRR; Leucine-rich repeat (LRR) protein [Transcription]
      sd00033
      Location:67 → 90
      LRR_RI; leucine-rich repeat [structural motif]
      pfam13855
      Location:114 → 173
      LRR_8; Leucine rich repeat
      cd20969
      Location:417 → 508
      IgI_Lingo-1; Immunoglobulin I-set domain of the Leucine-rich repeat and immunoglobin-like domain-containing protein 1 (Lingo-1)

    2. XM_030244328.2 → XP_030100188.1  leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1 isoform X2

      UniProtKB/Swiss-Prot
      Q3TQJ4, Q6VVF9, Q7TT38, Q9D1T0
      Conserved Domains (6) summary
      TIGR00864
      Location:335 → 415
      PCC; polycystin cation channel protein
      smart00013
      Location:35 → 69
      LRRNT; Leucine rich repeat N-terminal domain
      COG4886
      Location:60 → 365
      LRR; Leucine-rich repeat (LRR) protein [Transcription]
      sd00033
      Location:67 → 90
      LRR_RI; leucine-rich repeat [structural motif]
      pfam13855
      Location:114 → 173
      LRR_8; Leucine rich repeat
      cd20969
      Location:417 → 508
      IgI_Lingo-1; Immunoglobulin I-set domain of the Leucine-rich repeat and immunoglobin-like domain-containing protein 1 (Lingo-1)

    3. XM_036154898.1 → XP_036010791.1  leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1 isoform X2

      UniProtKB/Swiss-Prot
      Q3TQJ4, Q6VVF9, Q7TT38, Q9D1T0
      Related
      ENSMUSP00000109885.2, ENSMUST00000114247.2
      Conserved Domains (6) summary
      TIGR00864
      Location:335 → 415
      PCC; polycystin cation channel protein
      smart00013
      Location:35 → 69
      LRRNT; Leucine rich repeat N-terminal domain
      COG4886
      Location:60 → 365
      LRR; Leucine-rich repeat (LRR) protein [Transcription]
      sd00033
      Location:67 → 90
      LRR_RI; leucine-rich repeat [structural motif]
      pfam13855
      Location:114 → 173
      LRR_8; Leucine rich repeat
      cd20969
      Location:417 → 508
      IgI_Lingo-1; Immunoglobulin I-set domain of the Leucine-rich repeat and immunoglobin-like domain-containing protein 1 (Lingo-1)

    4. XM_030244330.2 → XP_030100190.1  leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1 isoform X2

      UniProtKB/Swiss-Prot
      Q3TQJ4, Q6VVF9, Q7TT38, Q9D1T0
      Conserved Domains (6) summary
      TIGR00864
      Location:335 → 415
      PCC; polycystin cation channel protein
      smart00013
      Location:35 → 69
      LRRNT; Leucine rich repeat N-terminal domain
      COG4886
      Location:60 → 365
      LRR; Leucine-rich repeat (LRR) protein [Transcription]
      sd00033
      Location:67 → 90
      LRR_RI; leucine-rich repeat [structural motif]
      pfam13855
      Location:114 → 173
      LRR_8; Leucine rich repeat
      cd20969
      Location:417 → 508
      IgI_Lingo-1; Immunoglobulin I-set domain of the Leucine-rich repeat and immunoglobin-like domain-containing protein 1 (Lingo-1)

    5. XM_030244329.2 → XP_030100189.1  leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1 isoform X2

      UniProtKB/Swiss-Prot
      Q3TQJ4, Q6VVF9, Q7TT38, Q9D1T0
      Conserved Domains (6) summary
      TIGR00864
      Location:335 → 415
      PCC; polycystin cation channel protein
      smart00013
      Location:35 → 69
      LRRNT; Leucine rich repeat N-terminal domain
      COG4886
      Location:60 → 365
      LRR; Leucine-rich repeat (LRR) protein [Transcription]
      sd00033
      Location:67 → 90
      LRR_RI; leucine-rich repeat [structural motif]
      pfam13855
      Location:114 → 173
      LRR_8; Leucine rich repeat
      cd20969
      Location:417 → 508
      IgI_Lingo-1; Immunoglobulin I-set domain of the Leucine-rich repeat and immunoglobin-like domain-containing protein 1 (Lingo-1)

    6. XM_036154899.1 → XP_036010792.1  leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1 isoform X2

      UniProtKB/Swiss-Prot
      Q3TQJ4, Q6VVF9, Q7TT38, Q9D1T0
      Conserved Domains (6) summary
      TIGR00864
      Location:335 → 415
      PCC; polycystin cation channel protein
      smart00013
      Location:35 → 69
      LRRNT; Leucine rich repeat N-terminal domain
      COG4886
      Location:60 → 365
      LRR; Leucine-rich repeat (LRR) protein [Transcription]
      sd00033
      Location:67 → 90
      LRR_RI; leucine-rich repeat [structural motif]
      pfam13855
      Location:114 → 173
      LRR_8; Leucine rich repeat
      cd20969
      Location:417 → 508
      IgI_Lingo-1; Immunoglobulin I-set domain of the Leucine-rich repeat and immunoglobin-like domain-containing protein 1 (Lingo-1)

    7. XM_036154895.1 → XP_036010788.1  leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1 isoform X2

      UniProtKB/Swiss-Prot
      Q3TQJ4, Q6VVF9, Q7TT38, Q9D1T0
      Conserved Domains (6) summary
      TIGR00864
      Location:335 → 415
      PCC; polycystin cation channel protein
      smart00013
      Location:35 → 69
      LRRNT; Leucine rich repeat N-terminal domain
      COG4886
      Location:60 → 365
      LRR; Leucine-rich repeat (LRR) protein [Transcription]
      sd00033
      Location:67 → 90
      LRR_RI; leucine-rich repeat [structural motif]
      pfam13855
      Location:114 → 173
      LRR_8; Leucine rich repeat
      cd20969
      Location:417 → 508
      IgI_Lingo-1; Immunoglobulin I-set domain of the Leucine-rich repeat and immunoglobin-like domain-containing protein 1 (Lingo-1)

    8. XM_036154896.1 → XP_036010789.1  leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1 isoform X2

      UniProtKB/Swiss-Prot
      Q3TQJ4, Q6VVF9, Q7TT38, Q9D1T0
      Conserved Domains (6) summary
      TIGR00864
      Location:335 → 415
      PCC; polycystin cation channel protein
      smart00013
      Location:35 → 69
      LRRNT; Leucine rich repeat N-terminal domain
      COG4886
      Location:60 → 365
      LRR; Leucine-rich repeat (LRR) protein [Transcription]
      sd00033
      Location:67 → 90
      LRR_RI; leucine-rich repeat [structural motif]
      pfam13855
      Location:114 → 173
      LRR_8; Leucine rich repeat
      cd20969
      Location:417 → 508
      IgI_Lingo-1; Immunoglobulin I-set domain of the Leucine-rich repeat and immunoglobin-like domain-containing protein 1 (Lingo-1)

    9. XM_036154900.1 → XP_036010793.1  leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1 isoform X2

      UniProtKB/Swiss-Prot
      Q3TQJ4, Q6VVF9, Q7TT38, Q9D1T0
      Conserved Domains (6) summary
      TIGR00864
      Location:335 → 415
      PCC; polycystin cation channel protein
      smart00013
      Location:35 → 69
      LRRNT; Leucine rich repeat N-terminal domain
      COG4886
      Location:60 → 365
      LRR; Leucine-rich repeat (LRR) protein [Transcription]
      sd00033
      Location:67 → 90
      LRR_RI; leucine-rich repeat [structural motif]
      pfam13855
      Location:114 → 173
      LRR_8; Leucine rich repeat
      cd20969
      Location:417 → 508
      IgI_Lingo-1; Immunoglobulin I-set domain of the Leucine-rich repeat and immunoglobin-like domain-containing protein 1 (Lingo-1)

    10. XM_006511086.3 → XP_006511149.1  leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1 isoform X1

      Conserved Domains (6) summary
      TIGR00864
      Location:368 → 448
      PCC; polycystin cation channel protein
      smart00013
      Location:68 → 102
      LRRNT; Leucine rich repeat N-terminal domain
      COG4886
      Location:93 → 398
      LRR; Leucine-rich repeat (LRR) protein [Transcription]
      sd00033
      Location:100 → 123
      LRR_RI; leucine-rich repeat [structural motif]
      pfam13855
      Location:147 → 206
      LRR_8; Leucine rich repeat
      cl11960
      Location:466 → 541
      Ig; Immunoglobulin domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9D1T0.1 GenPept UniProtKB/Swiss-Prot:Q9D1T0

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