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    Rspo2 R-spondin 2 [ Mus musculus (house mouse) ]

    Gene ID: 239405, updated on 2-Apr-2024

    Summary

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    Official Symbol
    Rspo2provided by MGI
    Official Full Name
    R-spondin 2provided by MGI
    Primary source
    MGI:MGI:1922667
    See related
    Ensembl:ENSMUSG00000051920 AllianceGenome:MGI:1922667
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    ftls; D430027K22; 2610028F08Rik
    Summary
    Enables heparin binding activity. Acts upstream of or within several processes, including embryonic limb morphogenesis; negative regulation of odontogenesis of dentin-containing tooth; and respiratory system development. Located in cell surface and extracellular region. Is expressed in several structures, including brain; jaw; limb bud; pelvic urethra; and sensory organ. Human ortholog(s) of this gene implicated in tetraamelia syndrome 2. Orthologous to human RSPO2 (R-spondin 2). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in CNS E11.5 (RPKM 3.5), CNS E18 (RPKM 1.5) and 8 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    15 B3.1; 15 16.73 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (42884184..43034990, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (43020788..43171594, complement)

    Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene angiopoietin 1 Neighboring gene predicted gene, 17473 Neighboring gene STARR-seq mESC enhancer starr_38545 Neighboring gene predicted gene, 46505 Neighboring gene STARR-seq mESC enhancer starr_38546 Neighboring gene STARR-seq mESC enhancer starr_38547 Neighboring gene STARR-seq mESC enhancer starr_38548 Neighboring gene predicted gene, 41315 Neighboring gene STARR-seq mESC enhancer starr_38549 Neighboring gene STARR-seq mESC enhancer starr_38550 Neighboring gene STARR-seq mESC enhancer starr_38551 Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene Neighboring gene eukaryotic translation initiation factor 3, subunit E

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Synovial fibroblasts assume distinct functional identities and secrete R-spondin 2 in osteoarthritis. Knights AJ, et al. Ann Rheum Dis, 2023 Feb. PMID 36175067, Free PMC Article
    2. R-Spondin2, a Positive Canonical WNT Signaling Regulator, Controls the Expansion and Differentiation of Distal Lung Epithelial Stem/Progenitor Cells in Mice. Raslan AA, et al. Int J Mol Sci, 2022 Mar 13. PMID 35328508, Free PMC Article
    3. DNA methylation mediated RSPO2 to promote follicular development in mammals. Zhou X, et al. Cell Death Dis, 2021 Jun 26. PMID 34175894, Free PMC Article
    4. [Rspo2 controls C. rodentium infection outcome in mice]. Papapietro O, et al. Med Sci (Paris), 2013 Aug-Sep. PMID 24005619
    5. R-spondin 2 signalling mediates susceptibility to fatal infectious diarrhoea. Papapietro O, et al. Nat Commun, 2013. PMID 23695692, Free PMC Article

    See all (96) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Rspo2 exacerbates rheumatoid arthritis by targeting aggressive phenotype of fibroblast-like synoviocytes and disrupting chondrocyte homeostasis via Wnt/beta-catenin pathway.
      Title: Rspo2 exacerbates rheumatoid arthritis by targeting aggressive phenotype of fibroblast-like synoviocytes and disrupting chondrocyte homeostasis via Wnt/β-catenin pathway.
    2. Synovial fibroblasts assume distinct functional identities and secrete R-spondin 2 in osteoarthritis.
      Title: Synovial fibroblasts assume distinct functional identities and secrete R-spondin 2 in osteoarthritis.
    3. Identification of a regulatory pathway inhibiting adipogenesis via RSPO2.
      Title: Identification of a regulatory pathway inhibiting adipogenesis via RSPO2.
    4. Role of R-spondin 2 in arterial lymphangiogenesis and atherosclerosis.
      Title: Role of R-spondin 2 in arterial lymphangiogenesis and atherosclerosis.
    5. Synergistic roles of Wnt modulators R-spondin2 and R-spondin3 in craniofacial morphogenesis and dental development.
      Title: Synergistic roles of Wnt modulators R-spondin2 and R-spondin3 in craniofacial morphogenesis and dental development.
    6. R-spondin2 signaling is required for oocyte-driven intercellular communication and follicular growth.
      Title: R-spondin2 signaling is required for oocyte-driven intercellular communication and follicular growth.
    7. DNA methylation mediated RSPO2 to promote follicular development in mammals.
      Title: DNA methylation mediated RSPO2 to promote follicular development in mammals.
    8. R-spondin substitutes for neuronal input for taste cell regeneration in adult mice.
      Title: R-spondin substitutes for neuronal input for taste cell regeneration in adult mice.
    9. R-spondin 2 mediates neutrophil egress into the alveolar space through increased lung permeability.
      Title: R-spondin 2 mediates neutrophil egress into the alveolar space through increased lung permeability.
    10. These results suggest that SMN-derived Rspo2 plays a major role in AChR clustering and NMJ formation in the postsynaptic region, and muscle-derived Rspo2 also plays a substantial role in juxtaposition of the active zones and synaptic folds.
      Title: Differential effects of spinal motor neuron-derived and skeletal muscle-derived Rspo2 on acetylcholine receptor clustering at the neuromuscular junction.
    Submit: New GeneRIF Correction See all GeneRIFs (33)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables heparin binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables signaling receptor binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within Wnt signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within bone mineralization IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of canonical Wnt signaling pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of canonical Wnt signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within dopaminergic neuron differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within embryonic forelimb morphogenesis IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within embryonic forelimb morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within embryonic hindlimb morphogenesis IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within embryonic hindlimb morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within epithelial tube branching involved in lung morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in limb development ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within lung growth IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within multicellular organism development IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within negative regulation of odontogenesis of dentin-containing tooth IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within osteoblast differentiation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in positive regulation of Wnt signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within positive regulation of canonical Wnt signaling pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within positive regulation of canonical Wnt signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within positive regulation of canonical Wnt signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within response to stimulus IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within trachea cartilage morphogenesis IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cell surface IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in extracellular region IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    R-spondin-2
    Names
    R-spondin 2 homolog
    cristin-2
    cysteine-rich and single thrombospondin domain-containing protein 2
    mCristin-2
    roof plate-specific spondin-2

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001357956.1 → NP_001344885.1  R-spondin-2 isoform 2 precursor

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) contains a distinct 5' UTR and lacks an in-frame portion of the 5' coding region, compared to variant 1. The resulting isoform (2) has a shorter N-terminus, compared to isoform 1.
      Source sequence(s)
      AC121609, AC161450
      Consensus CDS
      CCDS27451.1
      UniProtKB/Swiss-Prot
      Q7TPX3, Q8BFU0
      Related
      ENSMUSP00000154600.2, ENSMUST00000226810.2
      Conserved Domains (1) summary
      pfam15913
      Location:40 → 144
      Furin-like_2; Furin-like repeat, cysteine-rich

    2. NM_001357957.1 → NP_001344886.1  R-spondin-2 isoform 1 precursor

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1).
      Source sequence(s)
      AC121609, AC161450
      Conserved Domains (1) summary
      pfam15913
      Location:47 → 151
      Furin-like_2; Furin-like repeat, cysteine-rich

    3. NM_172815.3 → NP_766403.1  R-spondin-2 isoform 2 precursor

      See identical proteins and their annotated locations for NP_766403.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) uses an alternate in-frame splice site in the 5' coding region compared to variant 1. It encodes isoform 2 which has a shorter N-terminus compared to isoform 1.
      Source sequence(s)
      AC121609, AC161450
      Consensus CDS
      CCDS27451.1
      UniProtKB/Swiss-Prot
      Q7TPX3, Q8BFU0
      Related
      ENSMUSP00000067325.7, ENSMUST00000063492.8
      Conserved Domains (1) summary
      pfam15913
      Location:40 → 144
      Furin-like_2; Furin-like repeat, cysteine-rich

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000081.7 Reference GRCm39 C57BL/6J

      Range
      42884184..43034990 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011245607.2 → XP_011243909.1  R-spondin-2 isoform X5

      See identical proteins and their annotated locations for XP_011243909.1

      Conserved Domains (1) summary
      pfam15913
      Location:47 → 151
      Furin-like_2; Furin-like repeat, cysteine-rich

    2. XM_017316596.3 → XP_017172085.2  R-spondin-2 isoform X4

      Conserved Domains (2) summary
      pfam15913
      Location:40 → 141
      Furin-like_2; Furin-like repeat, cysteine-rich
      pfam19028
      Location:144 → 197
      TSP1_spondin; Spondin-like TSP1 domain

    3. XM_011245609.3 → XP_011243911.2  R-spondin-2 isoform X2

      Conserved Domains (2) summary
      pfam15913
      Location:47 → 148
      Furin-like_2; Furin-like repeat, cysteine-rich
      pfam19028
      Location:151 → 204
      TSP1_spondin; Spondin-like TSP1 domain

    4. XM_030248538.2 → XP_030104398.2  R-spondin-2 isoform X4

      Conserved Domains (2) summary
      pfam15913
      Location:40 → 141
      Furin-like_2; Furin-like repeat, cysteine-rich
      pfam19028
      Location:144 → 197
      TSP1_spondin; Spondin-like TSP1 domain

    5. XM_036159394.1 → XP_036015287.1  R-spondin-2 isoform X3

      Conserved Domains (2) summary
      pfam15913
      Location:40 → 141
      Furin-like_2; Furin-like repeat, cysteine-rich
      pfam19028
      Location:145 → 198
      TSP1_spondin; Spondin-like TSP1 domain

    6. XM_036159393.1 → XP_036015286.1  R-spondin-2 isoform X1

      Conserved Domains (2) summary
      pfam15913
      Location:47 → 148
      Furin-like_2; Furin-like repeat, cysteine-rich
      pfam19028
      Location:152 → 205
      TSP1_spondin; Spondin-like TSP1 domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8BFU0.1 GenPept UniProtKB/Swiss-Prot:Q8BFU0

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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