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    Yipf6 Yip1 domain family, member 6 [ Mus musculus (house mouse) ]

    Gene ID: 77929, updated on 8-May-2024

    Summary

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    Official Symbol
    Yipf6provided by MGI
    Official Full Name
    Yip1 domain family, member 6provided by MGI
    Primary source
    MGI:MGI:1925179
    See related
    Ensembl:ENSMUSG00000047694 AllianceGenome:MGI:1925179
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    A430107J06Rik
    Summary
    Enables identical protein binding activity. Acts upstream of or within intestinal epithelial cell development. Located in COPII-coated ER to Golgi transport vesicle; cis-Golgi network; and trans-Golgi network. Orthologous to human YIPF6 (Yip1 domain family member 6). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in bladder adult (RPKM 7.2), placenta adult (RPKM 5.4) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Yipf6 in Genome Data Viewer
    Location:
    X C3; X 43.19 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) X NC_000086.8 (97979922..97992627)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (98936316..98949021)

    Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene oligophrenin 1 Neighboring gene predicted gene, 26000 Neighboring gene predicted gene, 57678 Neighboring gene protein (peptidyl-prolyl cis/trans isomerase) NIMA-interacting, 4 (parvulin) pseudogene Neighboring gene predicted gene, 52477

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. YIPF6 controls sorting of FGF21 into COPII vesicles and promotes obesity. Wang L, et al. Proc Natl Acad Sci U S A, 2019 Jul 23. PMID 31289229, Free PMC Article
    2. Yip1 domain family, member 6 (Yipf6) mutation induces spontaneous intestinal inflammation in mice. Brandl K, et al. Proc Natl Acad Sci U S A, 2012 Jul 31. PMID 22802641, Free PMC Article
    3. Control of a neuronal morphology program by an RNA-binding zinc finger protein, Unkempt. Murn J, et al. Genes Dev, 2015 Mar 1. PMID 25737280, Free PMC Article
    4. Genome-wide expression profiling of mid-gestation placenta and embryo using a 15,000 mouse developmental cDNA microarray. Tanaka TS, et al. Proc Natl Acad Sci U S A, 2000 Aug 1. PMID 10922068, Free PMC Article
    5. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. YIPF6 controls sorting of FGF21 into COPII vesicles and promotes obesity in mice.
      Title: YIPF6 controls sorting of FGF21 into COPII vesicles and promotes obesity.
    2. a tissue- and organ-specific function for Yipf6 in the maintenance of intestinal homeostasis and implicate the orthologous human gene as a disease susceptibility locus.
      Title: Yip1 domain family, member 6 (Yipf6) mutation induces spontaneous intestinal inflammation in mice.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Chemically induced (ENU) (1)  1 citation
    • Endonuclease-mediated (3) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC59484

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables identical protein binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in endoplasmic reticulum to Golgi vesicle-mediated transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within intestinal epithelial cell development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in COPII-coated ER to Golgi transport vesicle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in Golgi medial cisterna ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in Golgi trans cisterna ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cis-Golgi network IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in trans-Golgi network IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in trans-Golgi network IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in trans-Golgi network ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    protein YIPF6
    Names
    YIP1 family member 6

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_207633.2 → NP_997516.1  protein YIPF6

      See identical proteins and their annotated locations for NP_997516.1

      Status: VALIDATED

      Source sequence(s)
      AK030473, AL672103, BB642656
      Consensus CDS
      CCDS30296.1
      UniProtKB/Swiss-Prot
      Q8BR70, Q8C531
      UniProtKB/TrEMBL
      B1AV66
      Related
      ENSMUSP00000056039.6, ENSMUST00000054697.7
      Conserved Domains (1) summary
      cl21557
      Location:2 → 232
      Yip1; Yip1 domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000086.8 Reference GRCm39 C57BL/6J

      Range
      97979922..97992627
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006528337.3 → XP_006528400.1  protein YIPF6 isoform X1

      Conserved Domains (1) summary
      cl21557
      Location:19 → 249
      Yip1; Yip1 domain

    2. XM_006528338.5 → XP_006528401.3  protein YIPF6 isoform X2

      UniProtKB/Swiss-Prot
      Q8BR70, Q8C531
      UniProtKB/TrEMBL
      B1AV66
      Conserved Domains (1) summary
      cl21557
      Location:2 → 232
      Yip1; Yip1 domain

    3. XM_006528339.5 → XP_006528402.3  protein YIPF6 isoform X2

      UniProtKB/Swiss-Prot
      Q8BR70, Q8C531
      UniProtKB/TrEMBL
      B1AV66
      Related
      ENSMUSP00000117981.2, ENSMUST00000151353.8
      Conserved Domains (1) summary
      cl21557
      Location:2 → 232
      Yip1; Yip1 domain

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_030007.1: Suppressed sequence

      Description
      NM_030007.1: This RefSeq record was removed by NCBI staff. Contact info@ncbi.nlm.nih.gov for further information.
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8BR70.1 GenPept UniProtKB/Swiss-Prot:Q8BR70

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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