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    Pold2 polymerase (DNA directed), delta 2, regulatory subunit [ Mus musculus (house mouse) ]

    Gene ID: 18972, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Pold2provided by MGI
    Official Full Name
    polymerase (DNA directed), delta 2, regulatory subunitprovided by MGI
    Primary source
    MGI:MGI:1097163
    See related
    Ensembl:ENSMUSG00000020471 AllianceGenome:MGI:1097163
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    p50; 50kDa; po1D2
    Summary
    Predicted to enable DNA binding activity. Involved in DNA biosynthetic process. Part of delta DNA polymerase complex. Is expressed in several structures, including brain; early conceptus; genitourinary system; gut; and immune system. Orthologous to human POLD2 (DNA polymerase delta 2, accessory subunit). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in adrenal adult (RPKM 221.0), mammary gland adult (RPKM 85.3) and 22 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    11 A1; 11 3.88 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (5822180..5828256, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (5872180..5878256, complement)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene phosphoglycerate mutase 2 Neighboring gene STARR-positive B cell enhancer ABC_E9815 Neighboring gene STARR-seq mESC enhancer starr_28443 Neighboring gene polymerase (DNA directed), mu Neighboring gene AE binding protein 1 Neighboring gene STARR-positive B cell enhancer ABC_E6946 Neighboring gene predicted gene, 53664 Neighboring gene myosin, light polypeptide 7, regulatory Neighboring gene glucokinase Neighboring gene predicted gene 11967

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Early embryonic lethality of mice lacking POLD2. Wu X, et al. Mol Reprod Dev, 2023 Feb. PMID 36528861, Free PMC Article
    2. Identification of Pold2 as a novel interaction partner of protein inhibitor of activated STAT2. Zheng Y, et al. Int J Mol Med, 2012 Oct. PMID 22824807
    3. Cloning, chromosomal localization, and interspecies interaction of mouse DNA polymerase delta small subunit (PolD2). Hindges R, et al. Genomics, 1997 Aug 15. PMID 9286699
    4. Identification of a novel protein, PDIP38, that interacts with the p50 subunit of DNA polymerase delta and proliferating cell nuclear antigen. Liu L, et al. J Biol Chem, 2003 Mar 21. PMID 12522211
    5. Mediation of proliferating cell nuclear antigen (PCNA)-dependent DNA replication through a conserved p21(Cip1)-like PCNA-binding motif present in the third subunit of human DNA polymerase delta. Ducoux M, et al. J Biol Chem, 2001 Dec 28. PMID 11595739

    See all (28) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Early embryonic lethality of mice lacking POLD2.
      Title: Early embryonic lethality of mice lacking POLD2.
    2. A direct interaction between Pold2 and PIAS2 was confirmed by direct yeast two-hybrid.
      Title: Identification of Pold2 as a novel interaction partner of protein inhibitor of activated STAT2.
    3. The association of PDIP38 with pol delta was shown to occur in calf thymus tissue and mammalian cell extracts by GST-PDIP38 pull-down and coimmunoprecipitation experiments.
      Title: Identification of a novel protein, PDIP38, that interacts with the p50 subunit of DNA polymerase delta and proliferating cell nuclear antigen.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA biosynthetic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in DNA biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within DNA damage response IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within DNA repair IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in DNA replication ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in DNA strand elongation involved in DNA replication IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in DNA-templated DNA replication ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in error-prone translesion synthesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of delta DNA polymerase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of delta DNA polymerase complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of delta DNA polymerase complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of zeta DNA polymerase complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    DNA polymerase delta subunit 2
    Names
    DNA polymerase delta subunit p50
    NP_001348871.1
    NP_032920.2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001361942.1 → NP_001348871.1  DNA polymerase delta subunit 2

      Status: VALIDATED

      Source sequence(s)
      AL627069, AV329456, BM946479, BQ840484, CX565680
      Consensus CDS
      CCDS24407.1
      UniProtKB/Swiss-Prot
      O35654, Q99J61
      Conserved Domains (1) summary
      cd07387
      Location:215 → 452
      MPP_PolD2_C; PolD2 (DNA polymerase delta, subunit 2), C-terminal domain

    2. NM_008894.2 → NP_032920.2  DNA polymerase delta subunit 2

      See identical proteins and their annotated locations for NP_032920.2

      Status: VALIDATED

      Source sequence(s)
      BG078511, BM215242, BY093766, BY668936, CB205181
      Consensus CDS
      CCDS24407.1
      UniProtKB/Swiss-Prot
      O35654, Q99J61
      Related
      ENSMUSP00000099986.4, ENSMUST00000102922.10
      Conserved Domains (1) summary
      cd07387
      Location:215 → 452
      MPP_PolD2_C; PolD2 (DNA polymerase delta, subunit 2), C-terminal domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      5822180..5828256 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O35654.2 GenPept UniProtKB/Swiss-Prot:O35654

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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