Tnip1 TNFAIP3 interacting protein 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Tnip1provided by MGI
Official Full Name: TNFAIP3 interacting protein 1provided by MGI
Primary source: MGI:MGI:1926194
See related: Ensembl:ENSMUSG00000020400 AllianceGenome:MGI:1926194
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Nef; VAN; ABIN; Naf1; ABIN1; ABIN-1
Summary: Enables polyubiquitin modification-dependent protein binding activity. Involved in several processes, including MyD88-dependent toll-like receptor signaling pathway; negative regulation of I-kappaB kinase/NF-kappaB signaling; and positive regulation of inflammatory response. Located in cytoplasm. Is expressed in several structures, including alimentary system; brain; cardiovascular system; genitourinary system; and immune system. Orthologous to human TNIP1 (TNFAIP3 interacting protein 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in colon adult (RPKM 26.8), duodenum adult (RPKM 23.7) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 11 B1.3; 11 32.13 cM

Exon count:: 20

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	11	NC_000077.7 (54801613..54853766, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	11	NC_000077.6 (54910787..54962956, complement)

Chromosome 11 - NC_000077.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

ABIN1 (Q478) is Required to Prevent Hematopoietic Deficiencies through Regulating Type I IFNs Expression.
Title: ABIN1 (Q478) is Required to Prevent Hematopoietic Deficiencies through Regulating Type I IFNs Expression.
ABIN1 Inhibits Inflammation through Necroptosis-Dependent Pathway in Ulcerative Colitis.
Title: ABIN1 Inhibits Inflammation through Necroptosis-Dependent Pathway in Ulcerative Colitis.
ABIN-1 is a key regulator in RIPK1-dependent apoptosis (RDA) and necroptosis, and ABIN-1 deficiency potentiates necroptosis-based cancer therapy in colorectal cancer.
Title: ABIN-1 is a key regulator in RIPK1-dependent apoptosis (RDA) and necroptosis, and ABIN-1 deficiency potentiates necroptosis-based cancer therapy in colorectal cancer.
A20-Binding Inhibitor of Nuclear Factor-kappaB Targets beta-Arrestin2 to Attenuate Opioid Tolerance.
Title: A20-Binding Inhibitor of Nuclear Factor-κB Targets β-Arrestin2 to Attenuate Opioid Tolerance.
The ABIN-1 heterozygosity sensitizes innate immune response of Abin-1(+/)(-) mice in vivo by promoting the production of proinflammatory cytokines, which can be blocked upon inhibition of RIPK1 kinase.
Title: ABIN-1 heterozygosity sensitizes to innate immune response in both RIPK1-dependent and RIPK1-independent manner.
The splenic iMo of ABIN1[D485N] mice displayed high expression of mRNAs encoding proteins controlling cell division and were actively dividing; this may underlie the increased pMo and MoDC numbers, which are derived from iMo.
Title: Distinct signals and immune cells drive liver pathology and glomerulonephritis in ABIN1[D485N] mice.
These data show that the disease susceptibility proteins A20 and ABIN-1 synergistically prevent intestinal inflammation by restricting IEC death and preserving tissue integrity.
Title: A20 and ABIN-1 synergistically preserve intestinal epithelial cell survival.
It has been proposed that ABIN-1 provides a critical link between methionine1 ubiquitylation mediated by the LUBAC complex and lysine63 deubiquitylation by phospho-A20 to modulate the activation of RIPK1.
Title: ABIN-1 regulates RIPK1 activation by linking Met1 ubiquitylation with Lys63 deubiquitylation in TNF-RSC.
Reduced expression of TNIP1 was determined in hepatic ischemia/reperfusion (I/R) injury compared to normal mice. Then, TNIP1 transgene mice were used to determine the effects of TNIP1 on mice after treatment for I/R.
Title: TNIP1 alleviates hepatic ischemia/reperfusion injury via the TLR2-Myd88 pathway.
the data establish Tnip1 as a critical regulator of IL-17 biology and reveal a causal role of keratinocytes in the pathogenesis of psoriasis.
Title: Keratinocytes contribute intrinsically to psoriasis upon loss of Tnip1 function.

Submit: New GeneRIF Correction See all GeneRIFs (19)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Gene trapped (2)
Targeted (7) 1 citation
Chemically induced (ENU) (1)
Endonuclease-mediated (3)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables mitogen-activated protein kinase binding	IBA Inferred from Biological aspect of Ancestor more info
enables mitogen-activated protein kinase binding	ISO Inferred from Sequence Orthology more info
enables polyubiquitin modification-dependent protein binding	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in MyD88-dependent toll-like receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular response to lipopolysaccharide	IBA Inferred from Biological aspect of Ancestor more info
involved_in glycoprotein biosynthetic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within inflammatory response	IEA Inferred from Electronic Annotation more info
involved_in leukocyte cell-cell adhesion	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of ERK1 and ERK2 cascade	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of ERK1 and ERK2 cascade	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of canonical NF-kappaB signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of canonical NF-kappaB signal transduction	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of canonical NF-kappaB signal transduction	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of inflammatory response	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of protein deubiquitination	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: TNFAIP3-interacting protein 1

Names: A20-binding inhibitor of NF-kappa B activation; Nef-associated factor 1; virion-associated nuclear shuttling protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001199275.2 → NP_001186204.1 TNFAIP3-interacting protein 1 isoform 1

See identical proteins and their annotated locations for NP_001186204.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) contains an alternate exon in the 5' UTR, compared to variant 1. Variants 1 and 2 encode the same isoform (1).

Source sequence(s)

AL593846

Consensus CDS

CCDS24704.1

UniProtKB/Swiss-Prot

Q922A9, Q922F7, Q9EPP8, Q9R0X3, Q9WUU8

UniProtKB/TrEMBL

E9QM75

Related

ENSMUSP00000099792.2, ENSMUST00000102731.8

Conserved Domains (2) summary

COG1196
Location:311 → 542

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

cl19252
Location:227 → 264

MreC; rod shape-determining protein MreC
NM_001199276.2 → NP_001186205.1 TNFAIP3-interacting protein 1 isoform 2

See identical proteins and their annotated locations for NP_001186205.1

Status: VALIDATED

Description

Transcript Variant: This variant (3) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream in-frame start codon, compared to variant 1. The resulting isoform (2) has a shorter N-terminus, compared to isoform 1. Variants 3 and 4 encode the same isoform (2).

Source sequence(s)

AL593846

Consensus CDS

CCDS56769.1

UniProtKB/Swiss-Prot

Q922A9, Q922F7, Q9EPP8, Q9R0X3, Q9WUU8

Related

ENSMUSP00000104514.2, ENSMUST00000108886.8

Conserved Domains (2) summary

COG1196
Location:258 → 489

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

cl19252
Location:174 → 211

MreC; rod shape-determining protein MreC
NM_001271455.1 → NP_001258384.1 TNFAIP3-interacting protein 1 isoform 2

See identical proteins and their annotated locations for NP_001258384.1

Status: VALIDATED

Description

Transcript Variant: This variant (4) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream in-frame start codon, compared to variant 1. The resulting isoform (2) has a shorter N-terminus, compared to isoform 1. Variants 3 and 4 encode the same isoform (2).

Source sequence(s)

AL593846

Consensus CDS

CCDS56769.1

UniProtKB/Swiss-Prot

Q922A9, Q922F7, Q9EPP8, Q9R0X3, Q9WUU8

Related

ENSMUSP00000104513.2, ENSMUST00000108885.8

Conserved Domains (2) summary

COG1196
Location:258 → 489

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

cl19252
Location:174 → 211

MreC; rod shape-determining protein MreC
NM_001271456.1 → NP_001258385.1 TNFAIP3-interacting protein 1 isoform 3

See identical proteins and their annotated locations for NP_001258385.1

Status: VALIDATED

Description

Transcript Variant: This variant (5) differs in the 5' UTR and uses an alternate splice site in the 3' coding region, which results in a frameshift, compared to variant 1. The encoded isoform (3) is shorter and has a distinct C-terminus, compared to isoform 1.

Source sequence(s)

AL593846

Consensus CDS

CCDS70188.1

UniProtKB/Swiss-Prot

Q922A9, Q922F7, Q9EPP8, Q9R0X3, Q9WUU8

UniProtKB/TrEMBL

D3Z2W0

Related

ENSMUSP00000099791.3, ENSMUST00000102730.9

Conserved Domains (2) summary

COG1196
Location:311 → 542

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

cl19252
Location:227 → 264

MreC; rod shape-determining protein MreC
NM_021327.4 → NP_067302.2 TNFAIP3-interacting protein 1 isoform 1

See identical proteins and their annotated locations for NP_067302.2

Status: VALIDATED

Description

Transcript Variant: This variant (1) encodes the longest isoform (1). Variants 1 and 2 encode the same isoform (1).

Source sequence(s)

AL593846

Consensus CDS

CCDS24704.1

UniProtKB/Swiss-Prot

Q922A9, Q922F7, Q9EPP8, Q9R0X3, Q9WUU8

UniProtKB/TrEMBL

E9QM75

Related

ENSMUSP00000018482.7, ENSMUST00000018482.13

Conserved Domains (2) summary

COG1196
Location:311 → 542

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

cl19252
Location:227 → 264

MreC; rod shape-determining protein MreC

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000077.7 Reference GRCm39 C57BL/6J

Range

54801613..54853766 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_011249162.1 → XP_011247464.1 TNFAIP3-interacting protein 1 isoform X2

See identical proteins and their annotated locations for XP_011247464.1

UniProtKB/Swiss-Prot

Q922A9, Q922F7, Q9EPP8, Q9R0X3, Q9WUU8

UniProtKB/TrEMBL

D3Z2W0

Conserved Domains (2) summary

COG1196
Location:311 → 542

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

cl19252
Location:227 → 264

MreC; rod shape-determining protein MreC
XM_030246197.2 → XP_030102057.1 TNFAIP3-interacting protein 1 isoform X4

UniProtKB/Swiss-Prot

Q922A9, Q922F7, Q9EPP8, Q9R0X3, Q9WUU8

Conserved Domains (2) summary

COG1196
Location:258 → 489

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

cl19252
Location:174 → 211

MreC; rod shape-determining protein MreC
XM_011249163.4 → XP_011247465.1 TNFAIP3-interacting protein 1 isoform X3

See identical proteins and their annotated locations for XP_011247465.1

UniProtKB/Swiss-Prot

Q922A9, Q922F7, Q9EPP8, Q9R0X3, Q9WUU8

Conserved Domains (2) summary

COG1196
Location:258 → 489

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

cl19252
Location:174 → 211

MreC; rod shape-determining protein MreC
XM_030246199.1 → XP_030102059.1 TNFAIP3-interacting protein 1 isoform X6

UniProtKB/Swiss-Prot

Q922A9, Q922F7, Q9EPP8, Q9R0X3, Q9WUU8

Conserved Domains (2) summary

COG1196
Location:225 → 456

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

cl19252
Location:141 → 178

MreC; rod shape-determining protein MreC
XM_006533848.3 → XP_006533911.1 TNFAIP3-interacting protein 1 isoform X5

See identical proteins and their annotated locations for XP_006533911.1

UniProtKB/Swiss-Prot

Q922A9, Q922F7, Q9EPP8, Q9R0X3, Q9WUU8

Conserved Domains (2) summary

COG1196
Location:225 → 456

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

cl19252
Location:141 → 178

MreC; rod shape-determining protein MreC
XM_011249164.3 → XP_011247466.1 TNFAIP3-interacting protein 1 isoform X5

See identical proteins and their annotated locations for XP_011247466.1

UniProtKB/Swiss-Prot

Q922A9, Q922F7, Q9EPP8, Q9R0X3, Q9WUU8

Conserved Domains (2) summary

COG1196
Location:225 → 456

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

cl19252
Location:141 → 178

MreC; rod shape-determining protein MreC
XM_006533847.5 → XP_006533910.1 TNFAIP3-interacting protein 1 isoform X3

See identical proteins and their annotated locations for XP_006533910.1

UniProtKB/Swiss-Prot

Q922A9, Q922F7, Q9EPP8, Q9R0X3, Q9WUU8

Conserved Domains (2) summary

COG1196
Location:258 → 489

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

cl19252
Location:174 → 211

MreC; rod shape-determining protein MreC
XM_030246196.2 → XP_030102056.1 TNFAIP3-interacting protein 1 isoform X2

UniProtKB/Swiss-Prot

Q922A9, Q922F7, Q9EPP8, Q9R0X3, Q9WUU8

UniProtKB/TrEMBL

D3Z2W0

Conserved Domains (2) summary

COG1196
Location:311 → 542

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

cl19252
Location:227 → 264

MreC; rod shape-determining protein MreC
XM_006533846.5 → XP_006533909.1 TNFAIP3-interacting protein 1 isoform X1

See identical proteins and their annotated locations for XP_006533909.1

UniProtKB/Swiss-Prot

Q922A9, Q922F7, Q9EPP8, Q9R0X3, Q9WUU8

UniProtKB/TrEMBL

E9QM75

Related

ENSMUSP00000104517.4, ENSMUST00000108889.10

Conserved Domains (2) summary

COG1196
Location:311 → 542

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

cl19252
Location:227 → 264

MreC; rod shape-determining protein MreC