Rhof ras homolog family member F (in filopodia) [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Rhofprovided by MGI
Official Full Name: ras homolog family member F (in filopodia)provided by MGI
Primary source: MGI:MGI:1345629
See related: Ensembl:ENSMUSG00000029449 AllianceGenome:MGI:1345629
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Rif; Arhf; Ifld1
Summary: Predicted to enable GTP binding activity; GTPase activity; and protein kinase binding activity. Predicted to be involved in several processes, including cytoskeleton organization; regulation of actin cytoskeleton organization; and regulation of cell shape. Predicted to be located in cytoplasm and membrane. Predicted to be active in several cellular components, including cell cortex; cytoplasmic vesicle; and cytoskeleton. Orthologous to human RHOF (ras homolog family member F, filopodia associated). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in spleen adult (RPKM 35.2), small intestine adult (RPKM 26.9) and 17 other tissues See more
Orthologs: human all
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Genomic context

Location:: 5 F; 5 62.77 cM

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	5	NC_000071.7 (123256243..123270692, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	5	NC_000071.6 (123118180..123141808, complement)

Chromosome 5 - NC_000071.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

RHOF is required for NFkappaB activation by KLF4 in esophageal keratinocytes and is also important for esophageal keratinocyte proliferation and migration.
Title: KLF4 activates NFκB signaling and esophageal epithelial inflammation via the Rho-related GTP-binding protein RHOF.
small GTPase Rif does not appear to be critical for platelet function in mice. Functional overlap between Rif and other small GTPases may be responsible for the non-essential role of Rif in platelets
Title: The small GTPase Rif is dispensable for platelet filopodia generation in mice.
Rif-mDia1 interaction is involved in filopodium formation independent of Cdc42 and Rac effectors.
Title: Rif-mDia1 interaction is involved in filopodium formation independent of Cdc42 and Rac effectors.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (3) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AI845056 (e-PCR)
- UniSTS:164301

AI480526 (e-PCR)
- UniSTS:159446

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables GTP binding	IBA Inferred from Biological aspect of Ancestor more info
enables GTPase activity	IBA Inferred from Biological aspect of Ancestor more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info
enables protein kinase binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in actin filament organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in actin filament organization	ISO Inferred from Sequence Orthology more info
involved_in cell migration	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of actin cytoskeleton organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in small GTPase-mediated signal transduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: rho-related GTP-binding protein RhoF

Names: induced in fatty liver dystrophy 1; ras homolog gene family, member f (in filopodia)

NP_780301.1

EC 3.6.5.1

EC 3.6.5.2

EC 3.6.5.3

EC 3.6.5.4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_175092.3 → NP_780301.1 rho-related GTP-binding protein RhoF

See identical proteins and their annotated locations for NP_780301.1

Status: VALIDATED

Source sequence(s)

AC158114, CK617811, DV646753

Consensus CDS

CCDS39263.1

UniProtKB/Swiss-Prot

Q8BYP3

UniProtKB/TrEMBL

Q4VA10

Related

ENSMUSP00000031401.6, ENSMUST00000031401.6

Conserved Domains (1) summary

cd04132
Location:17 → 211

Rho4_like; Ras homology family 4 (Rho4) of small guanosine triphosphatases (GTPases)-like