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    Dnm1 dynamin 1 [ Mus musculus (house mouse) ]

    Gene ID: 13429, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Dnm1provided by MGI
    Official Full Name
    dynamin 1provided by MGI
    Primary source
    MGI:MGI:107384
    See related
    Ensembl:ENSMUSG00000026825 AllianceGenome:MGI:107384
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Dnm; Ftfl; mKIAA4093
    Summary
    This gene encodes a member of the dynamin subfamily of GTP-binding proteins. The encoded protein is a GTPase which is required for membrane recycling, including vesicle endocytosis in neurons. It may also be involved in cellular fission via association with microtubules and actin filaments. Mutations in this gene have been shown to cause seizures. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2014]
    Expression
    Biased expression in cerebellum adult (RPKM 188.3), cortex adult (RPKM 160.9) and 14 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    2 B; 2 22.09 cM
    Exon count:
    27
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (32198483..32243361, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (32308471..32353349, complement)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene SWI5 recombination repair homolog (yeast) Neighboring gene STARR-positive B cell enhancer ABC_E9197 Neighboring gene golgin A2 Neighboring gene microRNA 3154 Neighboring gene microRNA 199b Neighboring gene predicted gene, 52590 Neighboring gene predicted gene, 39787

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Altered Fast Synaptic Transmission in a Mouse Model of DNM1-Associated Developmental Epileptic Encephalopathy. McCabe MP, et al. eNeuro, 2021 Mar-Apr. PMID 33372033, Free PMC Article
    2. Overlaps, gaps, and complexities of mouse models of Developmental and Epileptic Encephalopathy. Wang W, et al. Neurobiol Dis, 2021 Jan. PMID 33301879, Free PMC Article
    3. Dynamin 1 Restrains Vesicular Release to a Subquantal Mode In Mammalian Adrenal Chromaffin Cells. Wu Q, et al. J Neurosci, 2019 Jan 9. PMID 30381405, Free PMC Article
    4. Reduction of dynamin 1 in the hippocampus of aged mice is associated with the decline in hippocampal‑dependent memory. Yoo DY, et al. Mol Med Rep, 2016 Nov. PMID 27748822
    5. 70-kDa Heat Shock Protein Downregulates Dynamin in Experimental Stroke: A New Therapeutic Target? Kim JY, et al. Stroke, 2016 Aug. PMID 27387989, Free PMC Article

    See all (137) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Sarcolemma wounding activates dynamin-dependent endocytosis in striated muscle.
      Title: Sarcolemma wounding activates dynamin-dependent endocytosis in striated muscle.
    2. Tau overexpression impairs neuronal endocytosis by decreasing the GTPase dynamin 1 through the miR-132/MeCP2 pathway.
      Title: Tau overexpression impairs neuronal endocytosis by decreasing the GTPase dynamin 1 through the miR-132/MeCP2 pathway.
    3. The present work with dyn1-KO mice further confirms that Ca(2+)-dependent transmitter release is mainly via subquantal mode, suggesting that subquantal release could be also important in other types of cells
      Title: Dynamin 1 Restrains Vesicular Release to a Subquantal Mode In Mammalian Adrenal Chromaffin Cells.
    4. Cellular fluorescein hyperfluorescence is dynamin-dependent.
      Title: Cellular fluorescein hyperfluorescence is dynamin-dependent and increased by Tetronic 1107 treatment.
    5. dynamin is a molecular motor which would be involved in GLUT4 translocation by facilitating exocytosis
      Title: A multiscale study of the role of dynamin in the regulation of glucose uptake.
    6. reveal functional differences between Dnm1a and Dnm1b isoforms in the presence of a challenge, i.e. toxic Dnm1(Ftfl), while reinforcing its effect explicitly in this model of severe pediatric epilepsy
      Title: Dynamin 1 isoform roles in a mouse model of severe childhood epileptic encephalopathy.
    7. in the mature epididymis, predominantly localized in clear cells of the distal segments
      Title: Developmental expression of the dynamin family of mechanoenzymes in the mouse epididymis.
    8. Dynamin may facilitate Fas-mediated apoptotic death in the brain, and Hsp70 may protect by preventing this trafficking.
      Title: 70-kDa Heat Shock Protein Downregulates Dynamin in Experimental Stroke: A New Therapeutic Target?
    9. These results suggested that dynamin 1 was susceptible to the aging process, and that a reduction in dynamin 1 may result in hippocampaldependent memory deficits by disrupting endocytosis and the release of neurotransmitters.
      Title: Reduction of dynamin 1 in the hippocampus of aged mice is associated with the decline in hippocampal‑dependent memory.
    10. Tissue-specific dynamin-1 deletion at the calyx of Held decreases short-term depression through a mechanism distinct from vesicle resupply.
      Title: Tissue-specific dynamin-1 deletion at the calyx of Held decreases short-term depression through a mechanism distinct from vesicle resupply.
    Submit: New GeneRIF Correction See all GeneRIFs (44)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • KIAA4093

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables D2 dopamine receptor binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables GDP binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GTPase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTPase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables GTPase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables SH3 domain binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables microtubule binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables nitric-oxide synthase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphatidylinositol-3,4,5-trisphosphate binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables phosphatidylinositol-4,5-bisphosphate binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein kinase binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein serine/threonine kinase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein-containing complex binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor internalization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in clathrin coat assembly involved in endocytosis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in endocytosis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in endosome organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in modulation of chemical synaptic transmission IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in modulation of chemical synaptic transmission IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of synaptic vesicle endocytosis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of synaptic vesicle recycling ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein homooligomerization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein homotetramerization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in receptor internalization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in receptor internalization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in receptor-mediated endocytosis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of synaptic vesicle endocytosis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of vesicle size IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in synaptic vesicle budding from presynaptic endocytic zone membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in synaptic vesicle budding from presynaptic endocytic zone membrane IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in synaptic vesicle endocytosis IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in synaptic vesicle endocytosis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in vesicle scission ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cell projection IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in clathrin-coated pit ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in clathrin-coated vesicle ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasmic vesicle IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endocytic vesicle ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in glutamatergic synapse IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in glutamatergic synapse IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of membrane coat IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in microtubule IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in myelin sheath HDA PubMed 
    located_in photoreceptor inner segment IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in photoreceptor ribbon synapse IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in presynapse IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in presynapse ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in presynaptic endocytic zone membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in presynaptic endocytic zone membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in synapse IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in synapse IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in synaptic vesicle ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in varicosity ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    dynamin-1
    Names
    dynamin I
    NP_001288666.1
    NP_001355608.1
    NP_034195.2
    XP_006497712.2
    XP_006497713.2
    XP_006497716.2
    XP_006497717.2
    XP_006497718.2
    XP_006497721.2
    XP_006497722.2
    XP_006497723.2
    XP_006497724.2
    XP_006497725.1
    XP_017170817.1
    XP_036013974.1

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001301737.1 → NP_001288666.1  dynamin-1 isoform 2

      See identical proteins and their annotated locations for NP_001288666.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) has multiple differences in the coding region, one of which results in a frameshift, compared to variant 1. The resulting protein (isoform 2) has a distinct C-terminus and is shorter than isoform 1. This variant contains the alternate "a" exon in the central coding region and the "b" splicing pattern in the 3' coding region (PMID:10398046, PMID:20700442).
      Source sequence(s)
      AK011651, AL808027, BC034679, BQ179370, BY297150, CA328097, CO425806
      Consensus CDS
      CCDS79772.1
      UniProtKB/Swiss-Prot
      A2AN50, A2AN51, A2AN54, A2AN55, P39053, Q3UNM1, Q5DTN7, Q61358, Q61359, Q61360, Q6PDM5, Q8JZZ4, Q9CSY7, Q9QXX1
      Related
      ENSMUSP00000077461.6, ENSMUST00000078352.12
      Conserved Domains (5) summary
      smart00053
      Location:6 → 245
      DYNc; Dynamin, GTPase
      PHA03378
      Location:752 → 844
      PHA03378; EBNA-3B; Provisional
      cd01256
      Location:520 → 629
      PH_dynamin; Dynamin pleckstrin homology (PH) domain
      pfam01031
      Location:216 → 502
      Dynamin_M; Dynamin central region
      pfam02212
      Location:657 → 745
      GED; Dynamin GTPase effector domain

    2. NM_001368679.1 → NP_001355608.1  dynamin-1 isoform 3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) contains two alternate exons in the mid-coding region and uses an alternate acceptor splice site at the 3' terminal exon compared to variant one. The resulting isoform (3) is longer than isoform 1.
      Source sequence(s)
      AL808027
      UniProtKB/Swiss-Prot
      A2AN50, A2AN51, A2AN54, A2AN55, P39053, Q3UNM1, Q5DTN7, Q61358, Q61359, Q61360, Q6PDM5, Q8JZZ4, Q9CSY7, Q9QXX1
      Conserved Domains (5) summary
      smart00053
      Location:6 → 245
      DYNc; Dynamin, GTPase
      PHA03378
      Location:752 → 863
      PHA03378; EBNA-3B; Provisional
      cd01256
      Location:520 → 629
      PH_dynamin; Dynamin pleckstrin homology (PH) domain
      pfam01031
      Location:216 → 502
      Dynamin_M; Dynamin central region
      pfam02212
      Location:656 → 745
      GED; Dynamin GTPase effector domain

    3. NM_010065.3 → NP_034195.2  dynamin-1 isoform 1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (1). This variant contains the alternate "b" exon in the central coding region and the "a" splicing pattern in the 3' coding region (PMID:10398046, PMID:20700442).
      Source sequence(s)
      AA387428, AI894003, AK011651, BC058623, BE860433, BM950315, BY297150, CX239206
      Consensus CDS
      CCDS38102.1
      UniProtKB/Swiss-Prot
      A2AN50, A2AN51, A2AN54, A2AN55, P39053, Q3UNM1, Q5DTN7, Q61358, Q61359, Q61360, Q6PDM5, Q8JZZ4, Q9CSY7, Q9QXX1
      Related
      ENSMUSP00000088618.6, ENSMUST00000091089.12
      Conserved Domains (5) summary
      smart00053
      Location:6 → 245
      DYNc; Dynamin, GTPase
      cd01256
      Location:514 → 625
      PH_dynamin; Dynamin pleckstrin homology (PH) domain
      pfam01031
      Location:216 → 501
      Dynamin_M; Dynamin central region
      pfam02212
      Location:653 → 741
      GED; Dynamin GTPase effector domain
      cl26464
      Location:743 → 860
      Atrophin-1; Atrophin-1 family

    RNA

    1. NR_125959.1 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) contains two alternate exons in the central region and uses an alternate splice site in the 3' terminal exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD). This variant contains the alternate "b" exon in the central region (PMID:20700442).
      Source sequence(s)
      BC034679, BY297150
      Related
      ENSMUST00000139624.8

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      32198483..32243361 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006497654.4 → XP_006497717.2  dynamin-1 isoform X4

      See identical proteins and their annotated locations for XP_006497717.2

      UniProtKB/TrEMBL
      A0A0J9YUE9, A0A0J9YUN4
      Related
      ENSMUSP00000144264.2, ENSMUST00000201433.4
      Conserved Domains (5) summary
      smart00053
      Location:6 → 245
      DYNc; Dynamin, GTPase
      PHA03247
      Location:747 → 844
      PHA03247; large tegument protein UL36; Provisional
      cd01256
      Location:520 → 629
      PH_dynamin; Dynamin pleckstrin homology (PH) domain
      pfam01031
      Location:216 → 502
      Dynamin_M; Dynamin central region
      pfam02212
      Location:657 → 745
      GED; Dynamin GTPase effector domain

    2. XM_006497649.3 → XP_006497712.2  dynamin-1 isoform X1

      UniProtKB/Swiss-Prot
      A2AN50, A2AN51, A2AN54, A2AN55, P39053, Q3UNM1, Q5DTN7, Q61358, Q61359, Q61360, Q6PDM5, Q8JZZ4, Q9CSY7, Q9QXX1
      Conserved Domains (5) summary
      smart00053
      Location:6 → 245
      DYNc; Dynamin, GTPase
      PHA03247
      Location:747 → 864
      PHA03247; large tegument protein UL36; Provisional
      cd01256
      Location:520 → 629
      PH_dynamin; Dynamin pleckstrin homology (PH) domain
      pfam01031
      Location:216 → 502
      Dynamin_M; Dynamin central region
      pfam02212
      Location:656 → 745
      GED; Dynamin GTPase effector domain

    3. XM_006497659.4 → XP_006497722.2  dynamin-1 isoform X7

      See identical proteins and their annotated locations for XP_006497722.2

      UniProtKB/Swiss-Prot
      A2AN50, A2AN51, A2AN54, A2AN55, P39053, Q3UNM1, Q5DTN7, Q61358, Q61359, Q61360, Q6PDM5, Q8JZZ4, Q9CSY7, Q9QXX1
      Conserved Domains (5) summary
      smart00053
      Location:6 → 245
      DYNc; Dynamin, GTPase
      PHA03378
      Location:752 → 844
      PHA03378; EBNA-3B; Provisional
      cd01256
      Location:520 → 629
      PH_dynamin; Dynamin pleckstrin homology (PH) domain
      pfam01031
      Location:216 → 502
      Dynamin_M; Dynamin central region
      pfam02212
      Location:657 → 745
      GED; Dynamin GTPase effector domain

    4. XM_006497655.4 → XP_006497718.2  dynamin-1 isoform X5

      UniProtKB/TrEMBL
      A0A0J9YUE9
      Related
      ENSMUSP00000108992.2, ENSMUST00000113365.8
      Conserved Domains (5) summary
      smart00053
      Location:6 → 245
      DYNc; Dynamin, GTPase
      PHA03247
      Location:747 → 844
      PHA03247; large tegument protein UL36; Provisional
      cd01256
      Location:520 → 629
      PH_dynamin; Dynamin pleckstrin homology (PH) domain
      pfam01031
      Location:216 → 502
      Dynamin_M; Dynamin central region
      pfam02212
      Location:657 → 745
      GED; Dynamin GTPase effector domain

    5. XM_036158081.1 → XP_036013974.1  dynamin-1 isoform X3

      UniProtKB/Swiss-Prot
      A2AN50, A2AN51, A2AN54, A2AN55, P39053, Q3UNM1, Q5DTN7, Q61358, Q61359, Q61360, Q6PDM5, Q8JZZ4, Q9CSY7, Q9QXX1
      Conserved Domains (5) summary
      smart00053
      Location:6 → 245
      DYNc; Dynamin, GTPase
      PHA03378
      Location:752 → 863
      PHA03378; EBNA-3B; Provisional
      cd01256
      Location:520 → 629
      PH_dynamin; Dynamin pleckstrin homology (PH) domain
      pfam01031
      Location:216 → 502
      Dynamin_M; Dynamin central region
      pfam02212
      Location:657 → 745
      GED; Dynamin GTPase effector domain

    6. XM_006497661.3 → XP_006497724.2  dynamin-1 isoform X8

      UniProtKB/Swiss-Prot
      A2AN50, A2AN51, A2AN54, A2AN55, P39053, Q3UNM1, Q5DTN7, Q61358, Q61359, Q61360, Q6PDM5, Q8JZZ4, Q9CSY7, Q9QXX1
      Related
      ENSMUSP00000108977.2, ENSMUST00000113350.8
      Conserved Domains (5) summary
      smart00053
      Location:6 → 245
      DYNc; Dynamin, GTPase
      PHA03378
      Location:752 → 844
      PHA03378; EBNA-3B; Provisional
      cd01256
      Location:520 → 629
      PH_dynamin; Dynamin pleckstrin homology (PH) domain
      pfam01031
      Location:216 → 502
      Dynamin_M; Dynamin central region
      pfam02212
      Location:657 → 745
      GED; Dynamin GTPase effector domain

    7. XM_006497653.4 → XP_006497716.2  dynamin-1 isoform X6

      UniProtKB/Swiss-Prot
      A2AN50, A2AN51, A2AN54, A2AN55, P39053, Q3UNM1, Q5DTN7, Q61358, Q61359, Q61360, Q6PDM5, Q8JZZ4, Q9CSY7, Q9QXX1
      Conserved Domains (5) summary
      smart00053
      Location:6 → 245
      DYNc; Dynamin, GTPase
      PHA03247
      Location:743 → 860
      PHA03247; large tegument protein UL36; Provisional
      cd01256
      Location:514 → 625
      PH_dynamin; Dynamin pleckstrin homology (PH) domain
      pfam01031
      Location:216 → 502
      Dynamin_M; Dynamin central region
      pfam02212
      Location:652 → 741
      GED; Dynamin GTPase effector domain

    8. XM_006497658.4 → XP_006497721.2  dynamin-1 isoform X7

      See identical proteins and their annotated locations for XP_006497721.2

      UniProtKB/Swiss-Prot
      A2AN50, A2AN51, A2AN54, A2AN55, P39053, Q3UNM1, Q5DTN7, Q61358, Q61359, Q61360, Q6PDM5, Q8JZZ4, Q9CSY7, Q9QXX1
      Related
      ENSMUSP00000143955.2, ENSMUST00000202578.4
      Conserved Domains (5) summary
      smart00053
      Location:6 → 245
      DYNc; Dynamin, GTPase
      PHA03378
      Location:752 → 844
      PHA03378; EBNA-3B; Provisional
      cd01256
      Location:520 → 629
      PH_dynamin; Dynamin pleckstrin homology (PH) domain
      pfam01031
      Location:216 → 502
      Dynamin_M; Dynamin central region
      pfam02212
      Location:657 → 745
      GED; Dynamin GTPase effector domain

    9. XM_006497650.4 → XP_006497713.2  dynamin-1 isoform X2

      UniProtKB/Swiss-Prot
      A2AN50, A2AN51, A2AN54, A2AN55, P39053, Q3UNM1, Q5DTN7, Q61358, Q61359, Q61360, Q6PDM5, Q8JZZ4, Q9CSY7, Q9QXX1
      Conserved Domains (5) summary
      smart00053
      Location:6 → 245
      DYNc; Dynamin, GTPase
      PHA03247
      Location:747 → 864
      PHA03247; large tegument protein UL36; Provisional
      cd01256
      Location:520 → 629
      PH_dynamin; Dynamin pleckstrin homology (PH) domain
      pfam01031
      Location:216 → 502
      Dynamin_M; Dynamin central region
      pfam02212
      Location:656 → 745
      GED; Dynamin GTPase effector domain

    10. XM_017315328.2 → XP_017170817.1  dynamin-1 isoform X8

      UniProtKB/Swiss-Prot
      A2AN50, A2AN51, A2AN54, A2AN55, P39053, Q3UNM1, Q5DTN7, Q61358, Q61359, Q61360, Q6PDM5, Q8JZZ4, Q9CSY7, Q9QXX1
      Related
      ENSMUSP00000108979.3, ENSMUST00000113352.9
      Conserved Domains (5) summary
      smart00053
      Location:6 → 245
      DYNc; Dynamin, GTPase
      PHA03378
      Location:752 → 844
      PHA03378; EBNA-3B; Provisional
      cd01256
      Location:520 → 629
      PH_dynamin; Dynamin pleckstrin homology (PH) domain
      pfam01031
      Location:216 → 502
      Dynamin_M; Dynamin central region
      pfam02212
      Location:657 → 745
      GED; Dynamin GTPase effector domain

    11. XM_006497662.3 → XP_006497725.1  dynamin-1 isoform X9

      UniProtKB/Swiss-Prot
      A2AN50, A2AN51, A2AN54, A2AN55, P39053, Q3UNM1, Q5DTN7, Q61358, Q61359, Q61360, Q6PDM5, Q8JZZ4, Q9CSY7, Q9QXX1
      Conserved Domains (5) summary
      cd08771
      Location:100 → 340
      DLP_1; Dynamin_like protein family includes dynamins and Mx proteins
      PHA03247
      Location:793 → 910
      PHA03247; large tegument protein UL36; Provisional
      cd01256
      Location:566 → 675
      PH_dynamin; Dynamin pleckstrin homology (PH) domain
      pfam01031
      Location:262 → 548
      Dynamin_M; Dynamin central region
      pfam02212
      Location:702 → 791
      GED; Dynamin GTPase effector domain

    12. XM_006497660.3 → XP_006497723.2  dynamin-1 isoform X7

      See identical proteins and their annotated locations for XP_006497723.2

      UniProtKB/Swiss-Prot
      A2AN50, A2AN51, A2AN54, A2AN55, P39053, Q3UNM1, Q5DTN7, Q61358, Q61359, Q61360, Q6PDM5, Q8JZZ4, Q9CSY7, Q9QXX1
      Conserved Domains (5) summary
      smart00053
      Location:6 → 245
      DYNc; Dynamin, GTPase
      PHA03378
      Location:752 → 844
      PHA03378; EBNA-3B; Provisional
      cd01256
      Location:520 → 629
      PH_dynamin; Dynamin pleckstrin homology (PH) domain
      pfam01031
      Location:216 → 502
      Dynamin_M; Dynamin central region
      pfam02212
      Location:657 → 745
      GED; Dynamin GTPase effector domain

    RNA

    1. XR_374055.3 RNA Sequence

    2. XR_004938046.1 RNA Sequence

    3. XR_001780675.2 RNA Sequence

    4. XR_004938043.1 RNA Sequence

    5. XR_004938042.1 RNA Sequence

    6. XR_004938044.1 RNA Sequence

    7. XR_374058.5 RNA Sequence

    8. XR_374057.4 RNA Sequence

    9. XR_001780678.3 RNA Sequence

    10. XR_003950433.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P39053.2 GenPept UniProtKB/Swiss-Prot:P39053

    Gene LinkOut

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