Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Treml2 triggering receptor expressed on myeloid cells-like 2 [ Mus musculus (house mouse) ]

    Gene ID: 328833, updated on 23-Jun-2021

    Summary

    Official Symbol
    Treml2provided by MGI
    Official Full Name
    triggering receptor expressed on myeloid cells-like 2provided by MGI
    Primary source
    MGI:MGI:2147038
    See related
    Ensembl:ENSMUSG00000071068
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Tlt2; Gm750; AW049306
    Expression
    Biased expression in spleen adult (RPKM 15.4), thymus adult (RPKM 10.4) and 5 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Treml2 in Genome Data Viewer
    Location:
    17; 17 C
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (48606419..48619562)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (48299390..48312534)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 17 NC_000083.5 (48439363..48451859)

    Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 52308 Neighboring gene predicted gene, 52307 Neighboring gene triggering receptor expressed on myeloid cells 3 Neighboring gene triggering receptor expressed on myeloid cells-like 4 Neighboring gene RIKEN cDNA B430306N03 gene Neighboring gene triggering receptor expressed on myeloid cells 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables signaling receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables signaling receptor activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in T cell activation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in T cell activation ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    is_active_in cell surface IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in cell surface ISO
    Inferred from Sequence Orthology
    more info
     
    located_in integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    trem-like transcript 2 protein
    Names
    TLT-2
    triggering receptor expressed on myeloid cells-like 2a dominant
    triggering receptor expressed on myeloid cells-like protein 2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001033405.2NP_001028577.2  trem-like transcript 2 protein isoform 1 precursor

      See identical proteins and their annotated locations for NP_001028577.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1).
      Source sequence(s)
      AC166164, AK037593, AK132018
      Consensus CDS
      CCDS37646.1
      UniProtKB/Swiss-Prot
      Q2LA85
      Related
      ENSMUSP00000156527.2, ENSMUST00000233092.2
      Conserved Domains (1) summary
      cl11960
      Location:33122
      Ig; Immunoglobulin domain
    2. NM_001360121.1NP_001347050.1  trem-like transcript 2 protein isoform 2 precursor

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 3' coding region, compared to variant 1. This results in a shorter protein (isoform 2), compared to isoform 1.
      Source sequence(s)
      AC166164, AC241601
      Consensus CDS
      CCDS89113.1
      Related
      ENSMUSP00000128215.3, ENSMUST00000170941.3
      Conserved Domains (1) summary
      cl11960
      Location:33122
      Ig; Immunoglobulin domain

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000083.7 Reference GRCm39 C57BL/6J

      Range
      48606419..48619562
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006524441.4XP_006524504.1  trem-like transcript 2 protein isoform X1

      See identical proteins and their annotated locations for XP_006524504.1

      UniProtKB/Swiss-Prot
      Q2LA85
      Conserved Domains (1) summary
      cl11960
      Location:33122
      Ig; Immunoglobulin domain
    2. XM_006524440.2XP_006524503.1  trem-like transcript 2 protein isoform X1

      See identical proteins and their annotated locations for XP_006524503.1

      UniProtKB/Swiss-Prot
      Q2LA85
      Conserved Domains (1) summary
      cl11960
      Location:33122
      Ig; Immunoglobulin domain
    Support Center