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    Gpr45 G protein-coupled receptor 45 [ Mus musculus (house mouse) ]

    Gene ID: 93690, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Gpr45provided by MGI
    Official Full Name
    G protein-coupled receptor 45provided by MGI
    Primary source
    MGI:MGI:2135882
    See related
    Ensembl:ENSMUSG00000041907 AllianceGenome:MGI:2135882
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    9230112G11Rik
    Summary
    Predicted to enable G protein-coupled receptor activity. Predicted to be involved in G protein-coupled receptor signaling pathway. Predicted to act upstream of or within signal transduction. Predicted to be integral component of membrane. Orthologous to human GPR45 (G protein-coupled receptor 45). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in CNS E18 (RPKM 2.3), whole brain E14.5 (RPKM 1.9) and 6 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    1 B; 1 21.88 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (42992032..43074611)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (42952872..43035451)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 53552 Neighboring gene mitochondrial ribosomal protein S9 Neighboring gene predicted gene, 23126 Neighboring gene predicted gene, 39633 Neighboring gene STARR-seq mESC enhancer starr_00772 Neighboring gene DnaJ (Hsp40) homolog, subfamily A, member 1 pseudogene Neighboring gene transforming growth factor, beta receptor associated protein 1 Neighboring gene predicted gene 28782 Neighboring gene RIKEN cDNA 8430432A02 gene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Disruption of Gpr45 causes reduced hypothalamic POMC expression and obesity. Cui J, et al. J Clin Invest, 2016 Sep 1. PMID 27500489, Free PMC Article
    2. Kisspeptin-GPR54 signaling in mouse NO-synthesizing neurons participates in the hypothalamic control of ovulation. Hanchate NK, et al. J Neurosci, 2012 Jan 18. PMID 22262891, Free PMC Article
    3. Brain-specific expression of novel G-protein-coupled receptors, with homologies to Xenopus PSP24 and human GPR45. Kawasawa Y, et al. Biochem Biophys Res Commun, 2000 Oct 5. PMID 11027574
    4. BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system. Magdaleno S, et al. PLoS Biol, 2006 Apr. PMID 16602821, Free PMC Article
    5. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. GPR45 is a regulator of POMC signaling and energy expenditure, which suggests that it may be a potential intervention target to combat obesity
      Title: Disruption of Gpr45 causes reduced hypothalamic POMC expression and obesity.
    2. Kisspeptin-GPR54 signaling in mouse NO-synthesizing neurons participates in the hypothalamic control of ovulation
      Title: Kisspeptin-GPR54 signaling in mouse NO-synthesizing neurons participates in the hypothalamic control of ovulation.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (1) 

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables G protein-coupled receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables G protein-coupled receptor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within G protein-coupled receptor signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    acts_upstream_of_or_within signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    probable G-protein coupled receptor 45
    Names
    PSP24-1
    PSP24-alpha
    PSP24alpha

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_053107.4 → NP_444337.3  probable G-protein coupled receptor 45

      See identical proteins and their annotated locations for NP_444337.3

      Status: VALIDATED

      Source sequence(s)
      AK039769, AK054151, BC118506
      Consensus CDS
      CCDS14919.1
      UniProtKB/Swiss-Prot
      Q9EQQ4
      UniProtKB/TrEMBL
      Q148B5, Q8CA29
      Related
      ENSMUSP00000135986.2, ENSMUST00000179766.3
      Conserved Domains (2) summary
      cd14964
      Location:36 → 62
      7tm_GPCRs; TM helix 1 [structural motif]
      cl28897
      Location:35 → 336
      7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      42992032..43074611
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036154462.1 → XP_036010355.1  probable G-protein coupled receptor 45 isoform X1

      UniProtKB/Swiss-Prot
      Q9EQQ4
      UniProtKB/TrEMBL
      Q148B5, Q8CA29
      Conserved Domains (2) summary
      cd14964
      Location:36 → 62
      7tm_GPCRs; TM helix 1 [structural motif]
      cl28897
      Location:35 → 336
      7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

    2. XM_006496346.4 → XP_006496409.1  probable G-protein coupled receptor 45 isoform X1

      See identical proteins and their annotated locations for XP_006496409.1

      UniProtKB/Swiss-Prot
      Q9EQQ4
      UniProtKB/TrEMBL
      Q148B5, Q8CA29
      Conserved Domains (2) summary
      cd14964
      Location:36 → 62
      7tm_GPCRs; TM helix 1 [structural motif]
      cl28897
      Location:35 → 336
      7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

    3. XM_017312993.3 → XP_017168482.1  probable G-protein coupled receptor 45 isoform X1

      UniProtKB/Swiss-Prot
      Q9EQQ4
      UniProtKB/TrEMBL
      Q148B5, Q8CA29
      Conserved Domains (2) summary
      cd14964
      Location:36 → 62
      7tm_GPCRs; TM helix 1 [structural motif]
      cl28897
      Location:35 → 336
      7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

    4. XM_006496347.4 → XP_006496410.1  probable G-protein coupled receptor 45 isoform X1

      See identical proteins and their annotated locations for XP_006496410.1

      UniProtKB/Swiss-Prot
      Q9EQQ4
      UniProtKB/TrEMBL
      Q148B5, Q8CA29
      Conserved Domains (2) summary
      cd14964
      Location:36 → 62
      7tm_GPCRs; TM helix 1 [structural motif]
      cl28897
      Location:35 → 336
      7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9EQQ4.1 GenPept UniProtKB/Swiss-Prot:Q9EQQ4

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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