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    Gvin1 GTPase, very large interferon inducible 1 [ Mus musculus (house mouse) ]

    Gene ID: 74558, updated on 8-Feb-2024

    Summary

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    Official Symbol
    Gvin1provided by MGI
    Official Full Name
    GTPase, very large interferon inducible 1provided by MGI
    Primary source
    MGI:MGI:1921808
    See related
    Ensembl:ENSMUSG00000045868 AllianceGenome:MGI:1921808
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    VLIG; Iigs1; VLIG-1; 9130002C22Rik; 9830104F22Rik
    Expression
    Broad expression in large intestine adult (RPKM 3.4), spleen adult (RPKM 2.8) and 23 other tissues See more
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    Genomic context

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    See Gvin1 in Genome Data Viewer
    Location:
    7 E3; 7 55.98 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (105755742..105814547, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (106156535..106215340, complement)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene GTPase, very large interferon inducible, pseudogene 3 Neighboring gene STARR-positive B cell enhancer mm9_chr7:113288424-113288725 Neighboring gene ornithine decarboxylase, structural 1 pseudogene Neighboring gene GTPase, very large interferon inducible, pseudogene 4 Neighboring gene STARR-positive B cell enhancer mm9_chr7:113356789-113357089 Neighboring gene STARR-positive B cell enhancer mm9_chr7:113357373-113357674 Neighboring gene STARR-positive B cell enhancer mm9_chr7:113358882-113359183 Neighboring gene STARR-positive B cell enhancer mm9_chr7:113359681-113359981 Neighboring gene STARR-positive B cell enhancer ABC_E4964 Neighboring gene STARR-positive B cell enhancer ABC_E2247 Neighboring gene STARR-seq mESC enhancer starr_19749 Neighboring gene STARR-positive B cell enhancer ABC_E8196 Neighboring gene STARR-positive B cell enhancer ABC_E10460 Neighboring gene STARR-positive B cell enhancer ABC_E10461 Neighboring gene STARR-positive B cell enhancer mm9_chr7:113440593-113440894 Neighboring gene STARR-seq mESC enhancer starr_19750 Neighboring gene GTPase, very large interferon inducible, pseudogene 5 Neighboring gene GTPase, very large interferon inducible, pseudogene 6 Neighboring gene predicted gene, 22372

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. A giant GTPase, very large inducible GTPase-1, is inducible by IFNs. Klamp T, et al. J Immunol, 2003 Aug 1. PMID 12874213
    2. WDFY4 is required for cross-presentation in response to viral and tumor antigens. Theisen DJ, et al. Science, 2018 Nov 9. PMID 30409884, Free PMC Article
    3. A CRISPR-based screen for Hedgehog signaling provides insights into ciliary function and ciliopathies. Breslow DK, et al. Nat Genet, 2018 Mar. PMID 29459677, Free PMC Article
    4. Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method. Piao Y, et al. Genome Res, 2001 Sep. PMID 11544199, Free PMC Article
    5. Fancd2 in vivo interaction network reveals a non-canonical role in mitochondrial function. Zhang T, et al. Sci Rep, 2017 Apr 5. PMID 28378742, Free PMC Article

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  

    General protein information

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    Preferred Names
    interferon-induced very large GTPase 1
    Names
    interferon inducible GTPase 1
    very large-inducible GTPase-1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001039160.2 → NP_001034249.2  interferon-induced very large GTPase 1

      See identical proteins and their annotated locations for NP_001034249.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks two internal exons in the 5' UTR and encodes the same protein, compared to variant 1.
      Source sequence(s)
      AC165356
      Consensus CDS
      CCDS21663.1
      UniProtKB/TrEMBL
      L7N451
      Related
      ENSMUSP00000006667.4, ENSMUST00000006667.11
      Conserved Domains (3) summary
      PRK00247
      Location:72 → 139
      PRK00247; putative inner membrane protein translocase component YidC; Validated
      TIGR02168
      Location:1206 → 1432
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      cl38936
      Location:1485 → 1562
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    2. NM_029000.3 → NP_083276.2  interferon-induced very large GTPase 1

      See identical proteins and their annotated locations for NP_083276.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) is the longer transcript. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      AC165356
      Consensus CDS
      CCDS21663.1
      UniProtKB/TrEMBL
      L7N451
      Related
      ENSMUSP00000138950.2, ENSMUST00000183409.2
      Conserved Domains (3) summary
      PRK00247
      Location:72 → 139
      PRK00247; putative inner membrane protein translocase component YidC; Validated
      TIGR02168
      Location:1206 → 1432
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      cl38936
      Location:1485 → 1562
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      105755742..105814547 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017312356.1 → XP_017167845.1  interferon-induced very large GTPase 1 isoform X1

      UniProtKB/TrEMBL
      L7N451
      Conserved Domains (3) summary
      PRK00247
      Location:72 → 139
      PRK00247; putative inner membrane protein translocase component YidC; Validated
      TIGR02168
      Location:1206 → 1432
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      cl38936
      Location:1485 → 1562
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q80SU7.1 GenPept UniProtKB/Swiss-Prot:Q80SU7

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