Arrb1 arrestin, beta 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Arrb1provided by MGI
Official Full Name: arrestin, beta 1provided by MGI
Primary source: MGI:MGI:99473
See related: Ensembl:ENSMUSG00000018909 AllianceGenome:MGI:99473
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 1200006I17Rik; G430100A01Rik
Summary: Enables cysteine-type endopeptidase inhibitor activity involved in apoptotic process and mitogen-activated protein kinase kinase binding activity. Involved in several processes, including negative regulation of Notch signaling pathway; positive regulation of cell communication; and regulation of cellular protein metabolic process. Acts upstream of or within phototransduction and regulation of G protein-coupled receptor signaling pathway. Located in cytosol and pseudopodium. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; liver; and respiratory system. Orthologous to human ARRB1 (arrestin beta 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in liver E14.5 (RPKM 46.5), liver E14 (RPKM 43.8) and 27 other tissues See more
Orthologs: human all
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Genomic context

Location:: 7 E1; 7 54.09 cM

Exon count:: 20

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	7	NC_000073.7 (99184356..99255979)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	7	NC_000073.6 (99535147..99606772)

Chromosome 7 - NC_000073.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Macrophage beta-arrestin-1 deteriorates DSS-induced colitis through interaction with NF-kappaB signaling.
Title: Macrophage β-arrestin-1 deteriorates DSS-induced colitis through interaction with NF-κB signaling.
Role of Formyl Peptide Receptors and beta-Arrestin-1 in suPAR Signal Transduction in Mouse Podocytes: Interactions with alphaVbeta3-Integrin.
Title: Role of Formyl Peptide Receptors and β-Arrestin-1 in suPAR Signal Transduction in Mouse Podocytes: Interactions with αVβ3-Integrin.
ARRB1 downregulates acetaminophen-induced hepatoxicity through binding to p-eIF2alpha to inhibit ER stress signaling.
Title: ARRB1 downregulates acetaminophen-induced hepatoxicity through binding to p-eIF2α to inhibit ER stress signaling.
Depletion of beta-arrestin-1 in macrophages enhances atherosclerosis in ApoE[-/-] mice.
Title: Depletion of β-arrestin-1 in macrophages enhances atherosclerosis in ApoE(-/-) mice.
beta-arrestin1 regulates astrocytic reactivity via Drp1-dependent mitochondrial fission: implications in postoperative delirium.
Title: β-arrestin1 regulates astrocytic reactivity via Drp1-dependent mitochondrial fission: implications in postoperative delirium.
Islet MC4R Regulates PC1/3 to Improve Insulin Secretion in T2DM Mice via the cAMP and beta-arrestin-1 Pathways.
Title: Islet MC4R Regulates PC1/3 to Improve Insulin Secretion in T2DM Mice via the cAMP and β-arrestin-1 Pathways.
ARRB2 (beta-Arrestin-2) Deficiency Alters Fluid Homeostasis and Blood Pressure Regulation.
Title: ARRB2 (β-Arrestin-2) Deficiency Alters Fluid Homeostasis and Blood Pressure Regulation.
HBx induces hepatocellular carcinogenesis through ARRB1-mediated autophagy to drive the G1/S cycle.
Title: HBx induces hepatocellular carcinogenesis through ARRB1-mediated autophagy to drive the G(1)/S cycle.
beta-arrestin1 promotes tauopathy by transducing GPCR signaling, disrupting microtubules and autophagy.
Title: β-arrestin1 promotes tauopathy by transducing GPCR signaling, disrupting microtubules and autophagy.
The Two beta-Arrestins Regulate Distinct Metabolic Processes: Studies with Novel Mutant Mouse Models.
Title: The Two β-Arrestins Regulate Distinct Metabolic Processes: Studies with Novel Mutant Mouse Models.

Submit: New GeneRIF Correction See all GeneRIFs (112)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (6) 1 citation
Endonuclease-mediated (3)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D7Bwg1382e (e-PCR), detects polymorphism
- UniSTS:142665

AW208571 (e-PCR)
- UniSTS:185729

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables AP-2 adaptor complex binding	ISO Inferred from Sequence Orthology more info
enables G protein-coupled receptor binding	IBA Inferred from Biological aspect of Ancestor more info
enables GTPase activator activity	ISO Inferred from Sequence Orthology more info
enables V2 vasopressin receptor binding	ISO Inferred from Sequence Orthology more info
enables alpha-1A adrenergic receptor binding	ISO Inferred from Sequence Orthology more info
enables alpha-1B adrenergic receptor binding	ISO Inferred from Sequence Orthology more info
enables angiotensin receptor binding	ISO Inferred from Sequence Orthology more info
enables arrestin family protein binding	ISO Inferred from Sequence Orthology more info
enables clathrin adaptor activity	ISO Inferred from Sequence Orthology more info
enables clathrin binding	ISO Inferred from Sequence Orthology more info
enables cysteine-type endopeptidase inhibitor activity involved in apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
enables enzyme binding	ISO Inferred from Sequence Orthology more info
enables follicle-stimulating hormone receptor binding	ISO Inferred from Sequence Orthology more info
enables insulin-like growth factor receptor binding	ISO Inferred from Sequence Orthology more info
enables mitogen-activated protein kinase kinase binding	IDA Inferred from Direct Assay more info	PubMed
enables nuclear estrogen receptor binding	ISO Inferred from Sequence Orthology more info
enables phosphoprotein binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein phosphorylated amino acid binding	ISO Inferred from Sequence Orthology more info
enables signaling receptor binding	ISO Inferred from Sequence Orthology more info
enables transcription coactivator activity	ISO Inferred from Sequence Orthology more info
enables transmembrane transporter binding	ISO Inferred from Sequence Orthology more info
enables ubiquitin protein ligase binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor internalization	IBA Inferred from Biological aspect of Ancestor more info
involved_in G protein-coupled receptor internalization	ISO Inferred from Sequence Orthology more info
involved_in G protein-coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in endocytosis	ISO Inferred from Sequence Orthology more info
involved_in follicle-stimulating hormone signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of ERK1 and ERK2 cascade	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of NF-kappaB transcription factor activity	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of Notch signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of Notch signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of Notch signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cysteine-type endopeptidase activity involved in apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of interleukin-6 production	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of interleukin-8 production	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of neuron apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of protein phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of protein ubiquitination	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of signal transduction	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within phototransduction	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of ERK1 and ERK2 cascade	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of ERK1 and ERK2 cascade	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of ERK1 and ERK2 cascade	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of MAPK cascade	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of Rho protein signal transduction	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of insulin secretion involved in cellular response to glucose stimulus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of peptidyl-serine phosphorylation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of protein binding	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of protein phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein ubiquitination	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of receptor internalization	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of smooth muscle cell apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within protein transport	IEA Inferred from Electronic Annotation more info
involved_in protein ubiquitination	ISO Inferred from Sequence Orthology more info
involved_in regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of G protein-coupled receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of G protein-coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in regulation of apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in signal transduction	IEA Inferred from Electronic Annotation more info
involved_in stress fiber assembly	ISO Inferred from Sequence Orthology more info
involved_in ubiquitin-dependent protein catabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in ubiquitin-dependent protein catabolic process	ISO Inferred from Sequence Orthology more info
involved_in visual perception	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in basolateral plasma membrane	ISO Inferred from Sequence Orthology more info
located_in cell projection	IEA Inferred from Electronic Annotation more info
part_of chromatin	ISO Inferred from Sequence Orthology more info
located_in clathrin-coated pit	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
is_active_in cytoplasmic vesicle	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasmic vesicle	ISO Inferred from Sequence Orthology more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	TAS Traceable Author Statement more info
located_in dendritic spine	ISO Inferred from Sequence Orthology more info
located_in endosome	ISO Inferred from Sequence Orthology more info
located_in intracellular anatomical structure	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in nuclear body	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in postsynaptic membrane	ISO Inferred from Sequence Orthology more info
located_in pseudopodium	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: beta-arrestin-1

Names: beta-arrestin1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_177231.2 → NP_796205.1 beta-arrestin-1 isoform A

See identical proteins and their annotated locations for NP_796205.1

Status: VALIDATED

Description

Transcript Variant: This variant (a) represents the longer transcript and encodes the longer protein (isoform A).

Source sequence(s)

AK147508, AK147566

Consensus CDS

CCDS40032.1

UniProtKB/Swiss-Prot

Q3UH95, Q8BTJ5, Q8BWG8

UniProtKB/TrEMBL

J3QNU6

Related

ENSMUSP00000095866.3, ENSMUST00000098266.9

Conserved Domains (2) summary

smart01017
Location:193 → 356

Arrestin_C; Arrestin (or S-antigen), C-terminal domain

pfam00339
Location:18 → 174

Arrestin_N; Arrestin (or S-antigen), N-terminal domain
NM_178220.3 → NP_835738.1 beta-arrestin-1 isoform B

See identical proteins and their annotated locations for NP_835738.1

Status: VALIDATED

Description

Transcript Variant: This variant (b) lacks an alternate exon in the 3' coding region compared to variant a. The resulting protein (isoform B) is shorter but has the same N- and C-termini compared to isoform A.

Source sequence(s)

AK090090, AK147508, AK147566

Consensus CDS

CCDS21484.1

UniProtKB/TrEMBL

J3QNU6

Related

ENSMUSP00000032995.9, ENSMUST00000032995.15

Conserved Domains (2) summary

smart01017
Location:193 → 348

Arrestin_C; Arrestin (or S-antigen), C-terminal domain

pfam00339
Location:18 → 174

Arrestin_N; Arrestin (or S-antigen), N-terminal domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000073.7 Reference GRCm39 C57BL/6J

Range

99184356..99255979

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006507198.5 → XP_006507261.1 beta-arrestin-1 isoform X1

UniProtKB/TrEMBL

J3QNU6

Conserved Domains (2) summary

smart01017
Location:230 → 393

Arrestin_C; Arrestin (or S-antigen), C-terminal domain

pfam00339
Location:55 → 211

Arrestin_N; Arrestin (or S-antigen), N-terminal domain
XM_006507199.5 → XP_006507262.1 beta-arrestin-1 isoform X2

UniProtKB/TrEMBL

J3QNU6

Conserved Domains (2) summary

smart01017
Location:230 → 385

Arrestin_C; Arrestin (or S-antigen), C-terminal domain

pfam00339
Location:55 → 211

Arrestin_N; Arrestin (or S-antigen), N-terminal domain
XM_006507200.3 → XP_006507263.1 beta-arrestin-1 isoform X5

UniProtKB/TrEMBL

J3QNU6

Conserved Domains (2) summary

smart01017
Location:188 → 351

Arrestin_C; Arrestin (or S-antigen), C-terminal domain

pfam00339
Location:13 → 169

Arrestin_N; Arrestin (or S-antigen), N-terminal domain
XM_036152569.1 → XP_036008462.1 beta-arrestin-1 isoform X4

UniProtKB/TrEMBL

J3QNU6

Conserved Domains (2) summary

smart01017
Location:188 → 343

Arrestin_C; Arrestin (or S-antigen), C-terminal domain

pfam00339
Location:13 → 169

Arrestin_N; Arrestin (or S-antigen), N-terminal domain
XM_011241644.3 → XP_011239946.1 beta-arrestin-1 isoform X3

UniProtKB/TrEMBL

J3QNU6

Conserved Domains (2) summary

smart01017
Location:205 → 368

Arrestin_C; Arrestin (or S-antigen), C-terminal domain

pfam00339
Location:30 → 186

Arrestin_N; Arrestin (or S-antigen), N-terminal domain