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    Ms4a2 membrane-spanning 4-domains, subfamily A, member 2 [ Mus musculus (house mouse) ]

    Gene ID: 14126, updated on 23-Jun-2021

    Summary

    Official Symbol
    Ms4a2provided by MGI
    Official Full Name
    membrane-spanning 4-domains, subfamily A, member 2provided by MGI
    Primary source
    MGI:MGI:95495
    See related
    Ensembl:ENSMUSG00000024680
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    FcR; FcRB; Fce1b; Fcer1; Fcrbe; Ms4a1; fcERI; Fcer1b; Fcrbeta
    Summary
    This gene encodes a member of the membrane-spanning 4A family. The encoded protein is the beta subunit of the high affinity IgE receptor and is localized to the membrane. The encoded protein is required for full activation of mast cells, including the release of histamine. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2013]
    Expression
    Low expression observed in reference dataset See more
    Orthologs
    NEW
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    Genomic context

    See Ms4a2 in Genome Data Viewer
    Location:
    19 A; 19 8.46 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (11592881..11601154, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (11615517..11623790, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 19 NC_000085.5 (11691683..11698133, complement)

    Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene membrane-spanning 4-domains, subfamily A, member 6D Neighboring gene predicted gene, 24599 Neighboring gene membrane-spanning 4-domains, subfamily A, member 3 Neighboring gene oocyte secreted protein 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (3)  1 citation
    • Endonuclease-mediated (1) 

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    contributes_to IgE binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    contributes_to IgE receptor activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables SH2 domain binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables phosphoprotein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein kinase binding ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    part_of Fc-epsilon receptor I complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in endosome ISO
    Inferred from Sequence Orthology
    more info
     
    located_in external side of plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in integral component of plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in integral component of plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in membrane raft ISO
    Inferred from Sequence Orthology
    more info
     
    located_in membrane raft TAS
    Traceable Author Statement
    more info
    PubMed 

    General protein information

    Preferred Names
    high affinity immunoglobulin epsilon receptor subunit beta
    Names
    Fc receptor, IgE, high affinity I, beta polypeptide
    fc epsilon receptor I beta-chain
    membrane-spanning 4-domains, subfamily A, member 1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001276328.1NP_001263257.1  high affinity immunoglobulin epsilon receptor subunit beta isoform b

      See identical proteins and their annotated locations for NP_001263257.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice site compared to variant 1. The encoded isoform (b) is shorter than isoform a.
      Source sequence(s)
      AK144021, AK161121, BY585879
      Consensus CDS
      CCDS70936.1
      UniProtKB/TrEMBL
      Q3UNT6
      Related
      ENSMUSP00000025583.6, ENSMUST00000025583.12
      Conserved Domains (1) summary
      pfam04103
      Location:52156
      CD20; CD20-like family
    2. NM_001276329.1NP_001263258.1  high affinity immunoglobulin epsilon receptor subunit beta isoform c

      See identical proteins and their annotated locations for NP_001263258.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) uses two alternate in-frame splice sites and lacks an in-frame exon in the 3' coding region, compared to variant 1. The encoded isoform (c) is shorter than isoform a.
      Source sequence(s)
      AK144021, AK161121, BY585879
      Consensus CDS
      CCDS79695.1
      UniProtKB/TrEMBL
      A0A0B4J1P0, Q3UNT6
      Related
      ENSMUSP00000140628.2, ENSMUST00000186978.7
    3. NM_001276330.1NP_001263259.1  high affinity immunoglobulin epsilon receptor subunit beta isoform d

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) lacks an in-frame exon and includes an alternate in-frame exon, compared to variant 1. The encoded isoform (d) is shorter than isoform a.
      Source sequence(s)
      AK161121, BB847820, BY585879, CN663232
      Consensus CDS
      CCDS79694.1
      UniProtKB/TrEMBL
      A0A087WPM9
      Related
      ENSMUSP00000139841.2, ENSMUST00000189641.2
      Conserved Domains (1) summary
      pfam04103
      Location:52160
      CD20; CD20-like family
    4. NM_013516.2NP_038544.1  high affinity immunoglobulin epsilon receptor subunit beta isoform a

      See identical proteins and their annotated locations for NP_038544.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a).
      Source sequence(s)
      AK144021, AK161121, BC139323, BY585879
      Consensus CDS
      CCDS29604.1
      UniProtKB/Swiss-Prot
      P20490
      UniProtKB/TrEMBL
      B2RTF7, Q3UNT6
      Related
      ENSMUSP00000127373.2, ENSMUST00000164792.8
      Conserved Domains (1) summary
      pfam04103
      Location:52192
      CD20; CD20-like family

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000085.7 Reference GRCm39 C57BL/6J

      Range
      11592881..11601154 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017318060.1XP_017173549.1  high affinity immunoglobulin epsilon receptor subunit beta isoform X1

      Conserved Domains (1) summary
      pfam04103
      Location:55150
      CD20; CD20-like family
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