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    Slc38a5 solute carrier family 38, member 5 [ Mus musculus (house mouse) ]

    Gene ID: 209837, updated on 21-Apr-2024

    Summary

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    Official Symbol
    Slc38a5provided by MGI
    Official Full Name
    solute carrier family 38, member 5provided by MGI
    Primary source
    MGI:MGI:2148066
    See related
    Ensembl:ENSMUSG00000031170 AllianceGenome:MGI:2148066
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    SN2; JM24; E330031E14
    Summary
    Predicted to enable amino acid transmembrane transporter activity. Predicted to be involved in amino acid transport. Predicted to be located in plasma membrane. Predicted to be integral component of membrane. Predicted to be integral component of plasma membrane. Is expressed in several structures, including central nervous system; foregut-midgut junction; liver lobe; metanephros; and pericardium. Orthologous to human SLC38A5 (solute carrier family 38 member 5). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in genital fat pad adult (RPKM 1166.3) and ovary adult (RPKM 77.4) See more
    Orthologs
    human all
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    Genomic context

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    Location:
    X A1.1; X 3.74 cM
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) X NC_000086.8 (8137620..8146418)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (8271381..8280179)

    Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_46693 Neighboring gene FtsJ RNA 2'-O-methyltransferase 1 Neighboring gene STARR-seq mESC enhancer starr_46694 Neighboring gene predicted gene, 54078 Neighboring gene SSX member B10 Neighboring gene SSX member B9

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Amino Acid Transporter Slc38a5 Controls Glucagon Receptor Inhibition-Induced Pancreatic α Cell Hyperplasia in Mice. Kim J, et al. Cell Metab, 2017 Jun 6. PMID 28591637, Free PMC Article
    2. Expression and function of system N glutamine transporters (SN1/SN2 or SNAT3/SNAT5) in retinal ganglion cells. Umapathy NS, et al. Invest Ophthalmol Vis Sci, 2008 Nov. PMID 18689705, Free PMC Article
    3. Amino acid transporter SLC38A5 regulates developmental and pathological retinal angiogenesis. Wang Z, et al. Elife, 2022 Dec 1. PMID 36454214, Free PMC Article
    4. Expression and function of glutamine transporters SN1 (SNAT3) and SN2 (SNAT5) in retinal Müller cells. Umapathy NS, et al. Invest Ophthalmol Vis Sci, 2005 Nov. PMID 16249471
    5. Neurodevelopmental consequences of Smn depletion in a mouse model of spinal muscular atrophy. Liu H, et al. J Neurosci Res, 2010 Jan. PMID 19642194

    See all (26) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Impairment of serine transport across the blood-brain barrier by deletion of Slc38a5 causes developmental delay and motor dysfunction.
      Title: Impairment of serine transport across the blood-brain barrier by deletion of Slc38a5 causes developmental delay and motor dysfunction.
    2. Amino acid transporter SLC38A5 is a tumor promoter and a novel therapeutic target for pancreatic cancer.
      Title: Amino acid transporter SLC38A5 is a tumor promoter and a novel therapeutic target for pancreatic cancer.
    3. These results show that Slc38a5 is a key component of the feedback circuit between glucagon receptor signaling in the liver and amino-acid-dependent regulation of pancreatic alpha cell mass in mice.
      Title: Amino Acid Transporter Slc38a5 Controls Glucagon Receptor Inhibition-Induced Pancreatic α Cell Hyperplasia in Mice.
    4. ISH and IF revealed SN1 and SN2 expression in the ganglion, inner nuclear, and photoreceptor cell layers.
      Title: Expression and function of system N glutamine transporters (SN1/SN2 or SNAT3/SNAT5) in retinal ganglion cells.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (1) 
    • Targeted (1) 
    • Endonuclease-mediated (2)  1 citation

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables L-asparagine transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables L-glutamine transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables L-glutamine transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables L-glutamine, sodium:proton antiporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables L-glutamine, sodium:proton antiporter activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables L-histidine transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables L-serine transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables alanine transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables amino acid transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables glycine transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables glycine transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables neutral L-amino acid transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables neutral amino acid, sodium:proton antiporter activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in L-alanine transmembrane transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in L-glutamine import across plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in L-glutamine import across plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in L-histidine transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in L-histidine transmembrane transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in L-serine import across plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in L-serine transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in amino acid export across plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in amino acid import across plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in asparagine transmembrane transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in glutamine transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in glutamine transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in glycine transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in glycine transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in neutral amino acid transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in serine transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in serine transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    sodium-coupled neutral amino acid transporter 5
    Names
    system N transporter 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_172479.3 → NP_766067.2  sodium-coupled neutral amino acid transporter 5

      See identical proteins and their annotated locations for NP_766067.2

      Status: VALIDATED

      Source sequence(s)
      AK054485, AK158125, AL805902, BX523289
      Consensus CDS
      CCDS52990.1
      UniProtKB/Swiss-Prot
      Q3TZ39, Q3U1J0, Q8BJZ6, Q8BW30
      Related
      ENSMUSP00000033512.5, ENSMUST00000033512.11
      Conserved Domains (2) summary
      COG0814
      Location:56 → 469
      SdaC; Amino acid permease [Amino acid transport and metabolism]
      cl00456
      Location:56 → 466
      SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000086.8 Reference GRCm39 C57BL/6J

      Range
      8137620..8146418
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q3U1J0.1 GenPept UniProtKB/Swiss-Prot:Q3U1J0

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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