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    Dnmbp dynamin binding protein [ Mus musculus (house mouse) ]

    Gene ID: 71972, updated on 23-Jun-2021

    Summary

    Official Symbol
    Dnmbpprovided by MGI
    Official Full Name
    dynamin binding proteinprovided by MGI
    Primary source
    MGI:MGI:1917352
    See related
    Ensembl:ENSMUSG00000025195
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Tub; TUBA; 2410003L07Rik; 2410003M15Rik
    Summary
    This gene encodes a member of the DBL family of guanine nucleotide exchange factors. The encoded protein has been proposed to regulate the actin cytoskeleton by specifically activating the Rho-family GTPase Cdc42. An interaction between the encoded protein and a Listeria protein has been shown to mediate Listeria infection. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2015]
    Expression
    Ubiquitous expression in colon adult (RPKM 15.1), large intestine adult (RPKM 10.7) and 27 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Dnmbp in Genome Data Viewer
    Location:
    19; 19 C3
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (43835254..43928677, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (43846815..43940232, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 19 NC_000085.5 (43922457..43986882, complement)

    Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene ATP-binding cassette, sub-family C (CFTR/MRP), member 2 Neighboring gene predicted gene 10768 Neighboring gene predicted gene, 24400 Neighboring gene predicted gene, 50217 Neighboring gene carboxypeptidase N, polypeptide 1 Neighboring gene cytochrome P450, family 2, subfamily c, polypeptide 23

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables guanyl-nucleotide exchange factor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables guanyl-nucleotide exchange factor activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in intracellular signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of cell shape ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cell junction IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cell-cell junction ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
     
    located_in presynapse ISO
    Inferred from Sequence Orthology
    more info
     
    located_in synapse ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    dynamin-binding protein
    Names
    scaffold protein Tuba

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001306088.1NP_001293017.1  dynamin-binding protein isoform 2

      See identical proteins and their annotated locations for NP_001293017.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) contains a distinct 5' UTR, lacks a portion of the 5' coding region, and uses a downstream in-frame start codon, compared to variant 1. The encoded isoform (2) has a shorter N-terminus compared to isoform 1.
      Source sequence(s)
      AC132251, AK010367, AK010372, CB245148, CN528320, CV308933
      Consensus CDS
      CCDS84442.1
      UniProtKB/Swiss-Prot
      Q6TXD4
      UniProtKB/TrEMBL
      A0A1D5RLL6, Q9CWU8
      Related
      ENSMUSP00000148421.2, ENSMUST00000212592.2
      Conserved Domains (4) summary
      cd07589
      Location:263454
      BAR_DNMBP; The Bin/Amphiphysin/Rvs (BAR) domain of Dynamin Binding Protein
      cd11798
      Location:535591
      SH3_DNMBP_C1; First C-terminal Src homology 3 domain of Dynamin Binding Protein, also called Tuba
      cd12141
      Location:763819
      SH3_DNMBP_C2; Second C-terminal Src homology 3 domain of Dynamin Binding Protein, also called Tuba, and similar domains
      cd00160
      Location:31211
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    2. NM_028029.4NP_082305.1  dynamin-binding protein isoform 1

      See identical proteins and their annotated locations for NP_082305.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AC132251, AK010367, AK010372, BP758285, CB245148, CJ099564, CN528320
      Consensus CDS
      CCDS29839.1
      UniProtKB/Swiss-Prot
      Q6TXD4
      UniProtKB/TrEMBL
      A0A0R4J055, Q9CWU8
      Related
      ENSMUSP00000148582.2, ENSMUST00000212396.2
      Conserved Domains (8) summary
      cd07589
      Location:10201211
      BAR_DNMBP; The Bin/Amphiphysin/Rvs (BAR) domain of Dynamin Binding Protein
      cd11794
      Location:756
      SH3_DNMBP_N1; First N-terminal Src homology 3 domain of Dynamin Binding Protein, also called Tuba
      cd11795
      Location:70124
      SH3_DNMBP_N2; Second N-terminal Src homology 3 domain of Dynamin Binding Protein, also called Tuba
      cd11796
      Location:150200
      SH3_DNMBP_N3; Third N-terminal Src homology 3 domain of Dynamin Binding Protein, also called Tuba
      cd11798
      Location:12921348
      SH3_DNMBP_C1; First C-terminal Src homology 3 domain of Dynamin Binding Protein, also called Tuba
      cd12141
      Location:15201576
      SH3_DNMBP_C2; Second C-terminal Src homology 3 domain of Dynamin Binding Protein, also called Tuba, and similar domains
      pfam00621
      Location:787969
      RhoGEF; RhoGEF domain
      cl17036
      Location:248297
      SH3; Src Homology 3 domain superfamily

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000085.7 Reference GRCm39 C57BL/6J

      Range
      43835254..43928677 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006527351.5XP_006527414.1  dynamin-binding protein isoform X1

      UniProtKB/TrEMBL
      A0A1D5RMB5
      Related
      ENSMUSP00000148708.2, ENSMUST00000212032.2
      Conserved Domains (8) summary
      cd07589
      Location:10161207
      BAR_DNMBP; The Bin/Amphiphysin/Rvs (BAR) domain of Dynamin Binding Protein
      cd11794
      Location:756
      SH3_DNMBP_N1; First N-terminal Src homology 3 domain of Dynamin Binding Protein, also called Tuba
      cd11795
      Location:70124
      SH3_DNMBP_N2; Second N-terminal Src homology 3 domain of Dynamin Binding Protein, also called Tuba
      cd11796
      Location:150200
      SH3_DNMBP_N3; Third N-terminal Src homology 3 domain of Dynamin Binding Protein, also called Tuba
      cd11798
      Location:12881344
      SH3_DNMBP_C1; First C-terminal Src homology 3 domain of Dynamin Binding Protein, also called Tuba
      cd12141
      Location:15161572
      SH3_DNMBP_C2; Second C-terminal Src homology 3 domain of Dynamin Binding Protein, also called Tuba, and similar domains
      cd00160
      Location:784964
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cl17036
      Location:248297
      SH3; Src Homology 3 domain superfamily
    2. XM_006527352.5XP_006527415.1  dynamin-binding protein isoform X2

      UniProtKB/TrEMBL
      A0A1D5RLY0
      Related
      ENSMUSP00000148546.2, ENSMUST00000212048.2
      Conserved Domains (4) summary
      cd07589
      Location:704895
      BAR_DNMBP; The Bin/Amphiphysin/Rvs (BAR) domain of Dynamin Binding Protein
      cd11798
      Location:9761032
      SH3_DNMBP_C1; First C-terminal Src homology 3 domain of Dynamin Binding Protein, also called Tuba
      cd12141
      Location:12041260
      SH3_DNMBP_C2; Second C-terminal Src homology 3 domain of Dynamin Binding Protein, also called Tuba, and similar domains
      cd00160
      Location:472652
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    3. XM_006527354.4XP_006527417.1  dynamin-binding protein isoform X3

      See identical proteins and their annotated locations for XP_006527417.1

      UniProtKB/TrEMBL
      A0A1D5RLL6
      Conserved Domains (4) summary
      cd07589
      Location:263454
      BAR_DNMBP; The Bin/Amphiphysin/Rvs (BAR) domain of Dynamin Binding Protein
      cd11798
      Location:535591
      SH3_DNMBP_C1; First C-terminal Src homology 3 domain of Dynamin Binding Protein, also called Tuba
      cd12141
      Location:763819
      SH3_DNMBP_C2; Second C-terminal Src homology 3 domain of Dynamin Binding Protein, also called Tuba, and similar domains
      cd00160
      Location:31211
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
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