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    E2f2 E2F transcription factor 2 [ Mus musculus (house mouse) ]

    Gene ID: 242705, updated on 11-Apr-2024

    Summary

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    Official Symbol
    E2f2provided by MGI
    Official Full Name
    E2F transcription factor 2provided by MGI
    Primary source
    MGI:MGI:1096341
    See related
    Ensembl:ENSMUSG00000018983 AllianceGenome:MGI:1096341
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    E2F-2
    Summary
    Enables DNA-binding transcription factor activity. Acts upstream of or within several processes, including intrinsic apoptotic signaling pathway by p53 class mediator; lens fiber cell apoptotic process; and regulation of transcription, DNA-templated. Located in nucleus. Is expressed in several structures, including alimentary system; cartilage condensation; central nervous system; early conceptus; and genitourinary system. Orthologous to human E2F2 (E2F transcription factor 2). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in thymus adult (RPKM 60.2), liver E14.5 (RPKM 28.6) and 10 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See E2f2 in Genome Data Viewer
    Location:
    4 D3; 4 68.34 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (135899585..135923368)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (136172274..136196057)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E4687 Neighboring gene STARR-seq mESC enhancer starr_11745 Neighboring gene predicted gene, 42329 Neighboring gene inhibitor of DNA binding 3 Neighboring gene STARR-positive B cell enhancer ABC_E10267 Neighboring gene CapStarr-seq enhancer MGSCv37_chr4:135727983-135728166 Neighboring gene STARR-positive B cell enhancer ABC_E3530 Neighboring gene STARR-seq mESC enhancer starr_11747 Neighboring gene STARR-positive B cell enhancer ABC_E6237 Neighboring gene STARR-positive B cell enhancer ABC_E427 Neighboring gene STARR-seq mESC enhancer starr_11748 Neighboring gene STARR-seq mESC enhancer starr_11749 Neighboring gene ArfGAP with SH3 domain, ankyrin repeat and PH domain 3 Neighboring gene STARR-seq mESC enhancer starr_11750 Neighboring gene transcription elongation factor A (SII), 3 Neighboring gene STARR-positive B cell enhancer ABC_E9604

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. The E2F2 transcription factor sustains hepatic glycerophospholipid homeostasis in mice. Maldonado EN, et al. PLoS One, 2014. PMID 25396754, Free PMC Article
    2. E2F2 and CREB cooperatively regulate transcriptional activity of cell cycle genes. Laresgoiti U, et al. Nucleic Acids Res, 2013 Dec. PMID 24038359, Free PMC Article
    3. A role for transcription factor E2F2 in hepatocyte proliferation and timely liver regeneration. Delgado I, et al. Am J Physiol Gastrointest Liver Physiol, 2011 Jul. PMID 21527726
    4. Differential proteomics analysis reveals a role for E2F2 in the regulation of the Ahr pathway in T lymphocytes. Azkargorta M, et al. Mol Cell Proteomics, 2010 Oct. PMID 20573986, Free PMC Article
    5. E2F2 suppresses Myc-induced proliferation and tumorigenesis. Pusapati RV, et al. Mol Carcinog, 2010 Feb. PMID 19798698, Free PMC Article

    See all (128) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. DNM3OS Enhances the Apoptosis and Senescence of Spermatogonia Associated with Nonobstructive Azoospermia by Providing miR-214-5p and Decreasing E2F2 Expression.
      Title: DNM3OS Enhances the Apoptosis and Senescence of Spermatogonia Associated with Nonobstructive Azoospermia by Providing miR-214-5p and Decreasing E2F2 Expression.
    2. E2F2 is upregulated by the ERK pathway and regulates decidualization via MCM4.
      Title: E2F2 is upregulated by the ERK pathway and regulates decidualization via MCM4.
    3. E2F2 Promotes Wound Healing of Diabetic Foot Ulcer by Regulating CDCA7L Transcription.
      Title: E2F2 Promotes Wound Healing of Diabetic Foot Ulcer by Regulating CDCA7L Transcription.
    4. Molecular Regulation of Heme Oxygenase-1 Expression by E2F Transcription Factor 2 in Lung Fibroblast Cells: Relevance to Idiopathic Pulmonary Fibrosis.
      Title: Molecular Regulation of Heme Oxygenase-1 Expression by E2F Transcription Factor 2 in Lung Fibroblast Cells: Relevance to Idiopathic Pulmonary Fibrosis.
    5. E2f2 Attenuates Apoptosis of Activated T Lymphocytes and Protects from Immune-Mediated Injury through Repression of Fas and FasL.
      Title: E2f2 Attenuates Apoptosis of Activated T Lymphocytes and Protects from Immune-Mediated Injury through Repression of Fas and FasL.
    6. Defined factors to reactivate cell cycle activity in adult mouse cardiomyocytes.
      Title: Defined factors to reactivate cell cycle activity in adult mouse cardiomyocytes.
    7. E2F1 and/or E2F2 likely play only a modest role in neuronal cell loss after brain trauma.
      Title: Comparing effects of CDK inhibition and E2F1/2 ablation on neuronal cell death pathways in vitro and after traumatic brain injury.
    8. E2F2 and CCND2 were identified as the targets of let-7i-5p, mediating its effect in regulating the cell cycle of cardiomyocyte.
      Title: Suppression of miRNA let-7i-5p promotes cardiomyocyte proliferation and repairs heart function post injury by targetting CCND2 and E2F2.
    9. Genomic structure, expression pattern, and functional characterization of transcription factor E2F-2 from black tiger
      Title: Genomic structure, expression pattern, and functional characterization of transcription factor E2F-2 from black tiger shrimp (Penaeus monodon).
    10. Findings implicate E2F-2 in regulating the expression of mitotic kinases that are adapted to perform specialized functions in nuclear condensation and enucleation of maturing erythroblasts.
      Title: E2F-2 Promotes Nuclear Condensation and Enucleation of Terminally Differentiated Erythroblasts.
    Submit: New GeneRIF Correction See all GeneRIFs (51)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (1)  1 citation
    • Endonuclease-mediated (3) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • E130207A07, 9230110J10

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    contributes_to DNA-binding transcription activator activity, RNA polymerase II-specific ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables DNA-binding transcription activator activity, RNA polymerase II-specific ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables DNA-binding transcription factor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    contributes_to RNA polymerase II transcription regulatory region sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables cis-regulatory region sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein dimerization activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables sequence-specific double-stranded DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within cell cycle IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within intrinsic apoptotic signaling pathway by p53 class mediator IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within lens fiber cell apoptotic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of sprouting angiogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within regulation of DNA-templated transcription IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of cell cycle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of RNA polymerase II transcription regulator complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of RNA polymerase II transcription regulator complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of transcription regulator complex IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    transcription factor E2F2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001305399.1 → NP_001292328.1  transcription factor E2F2 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and uses a downstream start codon compared to variant 1. It encodes isoform 2, which has a shorter N-terminus than isoform 1.
      Source sequence(s)
      AI553619, AK033797, AK087452, AL935264, AV381209, BQ830117, BY231313
      UniProtKB/TrEMBL
      Q3TZQ9
      Conserved Domains (1) summary
      cd14660
      Location:2 → 89
      E2F_DD; Dimerization domain of E2F transcription factors

    2. NM_177733.7 → NP_808401.1  transcription factor E2F2 isoform 1

      See identical proteins and their annotated locations for NP_808401.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AI553619, AK033797, AK087452, AL935264, AV381209, BC062101, CJ141952, CJ142800
      Consensus CDS
      CCDS18801.1
      UniProtKB/Swiss-Prot
      A2AW43, P56931, Q8BID0
      Related
      ENSMUSP00000050047.6, ENSMUST00000061721.6
      Conserved Domains (2) summary
      cd14660
      Location:207 → 308
      E2F_DD; Dimerization domain of E2F transcription factors
      pfam02319
      Location:133 → 196
      E2F_TDP; E2F/DP family winged-helix DNA-binding domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      135899585..135923368
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030253574.1 → XP_030109434.1  transcription factor E2F2 isoform X1

      Conserved Domains (2) summary
      cd14660
      Location:94 → 195
      E2F_DD; Dimerization domain of E2F transcription factors
      pfam02319
      Location:19 → 83
      E2F_TDP; E2F/DP family winged-helix DNA-binding domain

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_183301.1: Suppressed sequence

      Description
      NM_183301.1: This RefSeq was permanently suppressed because it is entirely UTR sequence.
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P56931.2 GenPept UniProtKB/Swiss-Prot:P56931

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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