Tsg101 tumor susceptibility gene 101 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Tsg101provided by MGI
Official Full Name: tumor susceptibility gene 101provided by MGI
Primary source: MGI:MGI:106581
See related: Ensembl:ENSMUSG00000014402 AllianceGenome:MGI:106581
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: CC2
Summary: Enables transcription corepressor activity. Involved in exosomal secretion; positive regulation of ubiquitin-dependent endocytosis; and viral budding. Acts upstream of or within several processes, including keratinocyte differentiation; negative regulation of transcription by RNA polymerase II; and regulation of cell growth. Located in cytoplasm and extracellular exosome. Is expressed in several structures, including alimentary system; genitourinary system; hemolymphoid system gland; limb; and nervous system. Human ortholog(s) of this gene implicated in breast cancer; breast carcinoma; cervix carcinoma; endometrial adenocarcinoma; and prostate cancer. Orthologous to human TSG101 (tumor susceptibility 101). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in CNS E11.5 (RPKM 29.9), CNS E14 (RPKM 28.1) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 7 B3; 7 30.62 cM

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	7	NC_000073.7 (46538693..46569716, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	7	NC_000073.6 (46888949..46926320, complement)

Chromosome 7 - NC_000073.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Regulation of c-SMAC formation and AKT-mTOR signaling by the TSG101-IFT20 axis in CD4[+] T cells.
Title: Regulation of c-SMAC formation and AKT-mTOR signaling by the TSG101-IFT20 axis in CD4(+) T cells.
Peripubertal requirement of Tsg101 in maintaining the integrity of membranous structures in mouse oocytes.
Title: Peripubertal requirement of Tsg101 in maintaining the integrity of membranous structures in mouse oocytes.
Tumor susceptibility gene 101 is required for the maintenance of uterine epithelial cells during embryo implantation.
Title: Tumor susceptibility gene 101 is required for the maintenance of uterine epithelial cells during embryo implantation.
MiR-17-5p-mediated endoplasmic reticulum stress promotes acute myocardial ischemia injury through targeting Tsg101.
Title: MiR-17-5p-mediated endoplasmic reticulum stress promotes acute myocardial ischemia injury through targeting Tsg101.
Tsg101 Is Necessary for the Establishment and Maintenance of Mouse Retinal Pigment Epithelial Cell Polarity.
Title: Tsg101 Is Necessary for the Establishment and Maintenance of Mouse Retinal Pigment Epithelial Cell Polarity.
Tsg101 positively regulates P62-Keap1-Nrf2 pathway to protect hearts against oxidative damage.
Title: Tsg101 positively regulates P62-Keap1-Nrf2 pathway to protect hearts against oxidative damage.
results indicate that TSG101 elevation could protect against endotoxin-triggered myocardial injury by promoting Parkin-induced mitophagy.
Title: Tumor susceptibility gene 101 ameliorates endotoxin-induced cardiac dysfunction by enhancing Parkin-mediated mitophagy.
mechanical stress upregulates TSG101 in podocytes.
Title: Upregulation of Tumor Susceptibility Gene 101 (TSG101) by mechanical stress in podocytes.
Tsg101 was deleted from mature oligodendroglia in vivo. This resulted in severe spongiform encephalopathy, histopathologically similar to that observed in Mgrn1 null mutant mice but with a more rapid onset.
Title: Oligodendroglial deletion of ESCRT-I component TSG101 causes spongiform encephalopathy.
BLOS1 interacts with sorting nexin 2 and the ESCRT-I component TSG101 to mediate the sorting of EGFR into endosomal compartments
Title: Biogenesis of lysosome-related organelles complex-1 subunit 1 (BLOS1) interacts with sorting nexin 2 and the endosomal sorting complex required for transport-I (ESCRT-I) component TSG101 to mediate the sorting of epidermal growth factor receptor into endosomal compartments.

Submit: New GeneRIF Correction See all GeneRIFs (21)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (4) 1 citation
Endonuclease-mediated (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

tsg101 (e-PCR), detects polymorphism
- UniSTS:144689

AI255943 (e-PCR)
- UniSTS:179575

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables calcium-dependent protein binding	ISO Inferred from Sequence Orthology more info
enables nuclear receptor coactivator activity	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein homodimerization activity	ISO Inferred from Sequence Orthology more info
enables protein-containing complex binding	ISO Inferred from Sequence Orthology more info
enables transcription corepressor activity	IDA Inferred from Direct Assay more info	PubMed
enables ubiquitin binding	IBA Inferred from Biological aspect of Ancestor more info
enables ubiquitin binding	ISO Inferred from Sequence Orthology more info
enables ubiquitin protein ligase binding	ISO Inferred from Sequence Orthology more info
enables virion binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within cell cycle	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cell differentiation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within cell division	IEA Inferred from Electronic Annotation more info
involved_in endosome to lysosome transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in endosome to lysosome transport	ISO Inferred from Sequence Orthology more info
involved_in exosomal secretion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in extracellular transport	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within keratinocyte differentiation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within negative regulation of cell population proliferation	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of epidermal growth factor receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of epidermal growth factor-activated receptor activity	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of exosomal secretion	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of ubiquitin-dependent endocytosis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of viral budding via host ESCRT complex	ISO Inferred from Sequence Orthology more info
involved_in protein modification process	IEA Inferred from Electronic Annotation more info
involved_in protein monoubiquitination	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within protein transport	IEA Inferred from Electronic Annotation more info
involved_in protein transport	IEA Inferred from Electronic Annotation more info
involved_in regulation of MAP kinase activity	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of cell cycle	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within regulation of cell growth	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of extracellular exosome assembly	ISO Inferred from Sequence Orthology more info
involved_in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway	ISO Inferred from Sequence Orthology more info
involved_in viral budding	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in viral budding	ISO Inferred from Sequence Orthology more info
involved_in viral release from host cell	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of ESCRT I complex	IBA Inferred from Biological aspect of Ancestor more info
part_of ESCRT I complex	ISO Inferred from Sequence Orthology more info
part_of ESCRT I complex	NAS Non-traceable Author Statement more info	PubMed
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in early endosome	ISO Inferred from Sequence Orthology more info
located_in endosome	ISO Inferred from Sequence Orthology more info
located_in endosome membrane	ISO Inferred from Sequence Orthology more info
located_in extracellular exosome	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular exosome	ISO Inferred from Sequence Orthology more info
located_in late endosome	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in nucleolus	ISO Inferred from Sequence Orthology more info
located_in nucleus	IC Inferred by Curator more info	PubMed
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: tumor susceptibility gene 101 protein

Names: ESCRT-I complex subunit TSG101

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001348088.2 → NP_001335017.1 tumor susceptibility gene 101 protein isoform 2

Status: VALIDATED

Description

Transcript Variant: This variant (2) lacks two alternate exons in the coding region compared to variant 1. The encoded isoform (2) is shorter compared to isoform 1.

Source sequence(s)

AC090123

UniProtKB/TrEMBL

Q3UK08

Conserved Domains (3) summary

TIGR02168
Location:189 → 331

SMC_prok_B; chromosome segregation protein SMC, common bacterial type

pfam05743
Location:21 → 139

UEV; UEV domain

pfam09454
Location:264 → 323

Vps23_core; Vps23 core domain
NM_001348089.2 → NP_001335018.1 tumor susceptibility gene 101 protein isoform 3

Status: VALIDATED

Description

Transcript Variant: This variant (3) uses an alternate splice site in the 5' region and uses a downstream start codon compared to variant 1. It encodes isoform 3 which has a shorter N-terminus compared to isoform 1.

Source sequence(s)

AC090123

UniProtKB/TrEMBL

A0A1B0GS09

Conserved Domains (3) summary

TIGR02168
Location:148 → 290

SMC_prok_B; chromosome segregation protein SMC, common bacterial type

pfam09454
Location:223 → 282

Vps23_core; Vps23 core domain

cl00154
Location:1 → 45

UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...
NM_001417440.1 → NP_001404369.1 tumor susceptibility gene 101 protein isoform 4

Status: VALIDATED

Source sequence(s)

AC090123
NM_021884.5 → NP_068684.1 tumor susceptibility gene 101 protein isoform 1

See identical proteins and their annotated locations for NP_068684.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).

Source sequence(s)

AC090123

Consensus CDS

CCDS21291.1

UniProtKB/Swiss-Prot

Q61187

UniProtKB/TrEMBL

Q3UCW0, Q3UK08

Related

ENSMUSP00000014546.9, ENSMUST00000014546.15

Conserved Domains (3) summary

TIGR02168
Location:242 → 384

SMC_prok_B; chromosome segregation protein SMC, common bacterial type

pfam05743
Location:21 → 139

UEV; UEV domain

pfam09454
Location:317 → 376

Vps23_core; Vps23 core domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000073.7 Reference GRCm39 C57BL/6J

Range

46538693..46569716 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_030242362.2 → XP_030098222.1 tumor susceptibility gene 101 protein isoform X1

UniProtKB/TrEMBL

A0A1B0GS09

Related

ENSMUSP00000147748.2, ENSMUST00000209538.2

Conserved Domains (3) summary

TIGR02168
Location:95 → 237

SMC_prok_B; chromosome segregation protein SMC, common bacterial type

pfam09454
Location:170 → 229

Vps23_core; Vps23 core domain

cl00154
Location:1 → 45

UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...