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    Adgrg2 adhesion G protein-coupled receptor G2 [ Mus musculus (house mouse) ]

    Gene ID: 237175, updated on 21-Apr-2024

    Summary

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    Official Symbol
    Adgrg2provided by MGI
    Official Full Name
    adhesion G protein-coupled receptor G2provided by MGI
    Primary source
    MGI:MGI:2446854
    See related
    Ensembl:ENSMUSG00000031298 AllianceGenome:MGI:2446854
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Me6; Gpr64; B830041D06Rik
    Summary
    Predicted to enable G protein-coupled receptor activity. Predicted to be involved in adenylate cyclase-activating G protein-coupled receptor signaling pathway. Predicted to act upstream of or within G protein-coupled receptor signaling pathway. Predicted to be located in apical plasma membrane and cytosol. Predicted to be integral component of plasma membrane. Is expressed in dorsal root ganglion; facial ganglion; foot; hand; and trigeminal ganglion. Human ortholog(s) of this gene implicated in X-linked congenital bilateral absence of vas deferens. Orthologous to human ADGRG2 (adhesion G protein-coupled receptor G2). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in genital fat pad adult (RPKM 104.9) and limb E14.5 (RPKM 8.2) See more
    Orthologs
    human all
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    Genomic context

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    Location:
    X F4; X 73.95 cM
    Exon count:
    31
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) X NC_000086.8 (159173315..159281072)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (160390318..160498076)

    Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene predicted gene, 39548 Neighboring gene abl-interactor 1 pseudogene Neighboring gene STARR-seq mESC enhancer starr_48182 Neighboring gene predicted gene 15241 Neighboring gene phosphorylase kinase alpha 2 Neighboring gene STARR-seq mESC enhancer starr_48183 Neighboring gene protein phosphatase with EF hand calcium-binding domain 1 Neighboring gene STARR-seq mESC enhancer starr_48184

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Adhesion receptor ADGRG2/GPR64 is in the GI-tract selectively expressed in mature intestinal tuft cells. Grunddal KV, et al. Mol Metab, 2021 Sep. PMID 33831593, Free PMC Article
    2. Optimization of a peptide ligand for the adhesion GPCR ADGRG2 provides a potent tool to explore receptor biology. Sun Y, et al. J Biol Chem, 2021 Jan-Jun. PMID 33303626, Free PMC Article
    3. Identification of the tethered peptide agonist of the adhesion G protein-coupled receptor GPR64/ADGRG2. Demberg LM, et al. Biochem Biophys Res Commun, 2015 Aug 28. PMID 26188515
    4. HE6/GPR64 adhesion receptor co-localizes with apical and subapical F-actin scaffold in male excurrent duct epithelia. Kirchhoff C, et al. Reproduction, 2008 Aug. PMID 18469038
    5. Targeted deletion of the epididymal receptor HE6 results in fluid dysregulation and male infertility. Davies B, et al. Mol Cell Biol, 2004 Oct. PMID 15367682, Free PMC Article

    See all (31) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Adhesion receptor ADGRG2/GPR64 is in the GI-tract selectively expressed in mature intestinal tuft cells.
      Title: Adhesion receptor ADGRG2/GPR64 is in the GI-tract selectively expressed in mature intestinal tuft cells.
    2. Optimization of a peptide ligand for the adhesion GPCR ADGRG2 provides a potent tool to explore receptor biology.
      Title: Optimization of a peptide ligand for the adhesion GPCR ADGRG2 provides a potent tool to explore receptor biology.
    3. The authors demonstrated that the ubiquitous G protein-coupled receptor signaling proteins Gq and beta-arrestin-1 are essential for fluid reabsorption because they mediate coupling between an orphan receptor ADGRG2 (GPR64) and the ion channel CFTR.
      Title: Gq activity- and β-arrestin-1 scaffolding-mediated ADGRG2/CFTR coupling are required for male fertility.
    4. Study identified Gpr64 as a P4-PGR target gene in the mouse uterus. P4 induced GPR64 expression in the epithelial and stromal cells of the uterus in ovariectomized wild-type mice, but not in PRKO mice. ChIP analysis confirmed that PGR proteins were recruited on progesterone response element of Gpr64 gene in the uteri of wild-type mice treated with P4.
      Title: G-protein coupled receptor 64 is required for decidualization of endometrial stromal cells.
    5. examined the G protein-coupling abilities of GPR64 and showed that it is activated through a tethered agonist sequence, which we have previously identified as the Stachel sequence
      Title: Identification of the tethered peptide agonist of the adhesion G protein-coupled receptor GPR64/ADGRG2.
    6. GPR64 expression in ES maintains an immature phenotype that is less sensitive to TRAIL-induced apoptosis and via its up-regulation of PGF and MMP1 orchestrates and promotes invasiveness and metastatic spread in Ewing sarcoma.
      Title: G-Protein coupled receptor 64 promotes invasiveness and metastasis in Ewing sarcomas through PGF and MMP1.
    7. Affymetrix expression profiling shows that the C terminus of Runx2 regulates genes involved in G protein-coupled receptor signaling Rgs2, Rgs4, Rgs5, Rgs16, Gpr23, Gpr30, Gpr54, Gpr64, and Gna13.
      Title: Runx2 regulates G protein-coupled signaling pathways to control growth of osteoblast progenitors.
    8. The knockout of the HE6/Gpr64 receptor was mainly associated with the downregulation of genes specific to the initial segment.
      Title: Novel epididymis-specific mRNAs downregulated by HE6/Gpr64 receptor gene disruption.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables G protein-coupled receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables transmembrane signaling receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within G protein-coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in G protein-coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cell surface receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in apical plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    adhesion G-protein coupled receptor G2
    Names
    G protein coupled receptor He6
    G-protein coupled receptor 64
    LNB-TM7 heptahelical receptor Me6
    epididymis-specific protein 6

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001079847.2 → NP_001073316.1  adhesion G-protein coupled receptor G2 isoform 3 precursor

      See identical proteins and their annotated locations for NP_001073316.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) uses an alternate in-frame splice site and lacks an alternate in-frame exon, compared to variant 1. The encoded isoform (3) is shorter than isoform 1.
      Source sequence(s)
      AL731801, BC115874, BY769670
      Consensus CDS
      CCDS41198.1
      UniProtKB/TrEMBL
      A2AHQ2, Q14BH6
      Related
      ENSMUSP00000108020.2, ENSMUST00000112401.8
      Conserved Domains (4) summary
      cd15444
      Location:600 → 869
      7tmB2_GPR64; orphan adhesion receptor GPR64 and related proteins, member of subfamily B2 of the class B secretin-like receptors of seven-transmembrane G protein-coupled receptors
      pfam01825
      Location:544 → 587
      GPS; GPCR proteolysis site, GPS, motif
      pfam03154
      Location:196 → 469
      Atrophin-1; Atrophin-1 family
      NF033913
      Location:222 → 342
      fibronec_FbpA; LPXTG-anchored fibronectin-binding protein FbpA

    2. NM_001079848.2 → NP_001073317.1  adhesion G-protein coupled receptor G2 isoform 4

      See identical proteins and their annotated locations for NP_001073317.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) lacks two alternate in-frame exons, compared to variant 1. The encoded isoform (4) is shorter than isoform 1.
      Source sequence(s)
      AL731801, BC115874, BY769670
      Consensus CDS
      CCDS41199.1
      UniProtKB/TrEMBL
      A2AHQ2
      Related
      ENSMUSP00000108023.3, ENSMUST00000112404.9
      Conserved Domains (4) summary
      cd15444
      Location:590 → 859
      7tmB2_GPR64; orphan adhesion receptor GPR64 and related proteins, member of subfamily B2 of the class B secretin-like receptors of seven-transmembrane G protein-coupled receptors
      pfam01825
      Location:534 → 577
      GPS; GPCR proteolysis site, GPS, motif
      pfam03154
      Location:186 → 459
      Atrophin-1; Atrophin-1 family
      NF033913
      Location:212 → 332
      fibronec_FbpA; LPXTG-anchored fibronectin-binding protein FbpA

    3. NM_001079857.2 → NP_001073326.1  adhesion G-protein coupled receptor G2 isoform 2 precursor

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
      Source sequence(s)
      AK046871, AL731801, BC115874, BY769670
      Consensus CDS
      CCDS41197.1
      UniProtKB/TrEMBL
      A2AHQ2
      Related
      ENSMUSP00000108021.2, ENSMUST00000112402.8
      Conserved Domains (4) summary
      cd15444
      Location:603 → 872
      7tmB2_GPR64; orphan adhesion receptor GPR64 and related proteins, member of subfamily B2 of the class B secretin-like receptors of seven-transmembrane G protein-coupled receptors
      pfam01825
      Location:547 → 590
      GPS; GPCR proteolysis site, GPS, motif
      pfam03154
      Location:199 → 472
      Atrophin-1; Atrophin-1 family
      NF033913
      Location:225 → 345
      fibronec_FbpA; LPXTG-anchored fibronectin-binding protein FbpA

    4. NM_001290445.1 → NP_001277374.1  adhesion G-protein coupled receptor G2 isoform 5 precursor

      See identical proteins and their annotated locations for NP_001277374.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) lacks an alternate in-frame exon, compared to variant 1. The encoded isoform (5) is shorter than isoform 1.
      Source sequence(s)
      AL731801, BC115874, BY769670
      Consensus CDS
      CCDS81192.1
      UniProtKB/TrEMBL
      A2AHQ2
      Related
      ENSMUSP00000108024.3, ENSMUST00000112405.9
      Conserved Domains (3) summary
      pfam01825
      Location:546 → 588
      GPS; GPCR proteolysis site, GPS, motif
      pfam16788
      Location:206 → 357
      ATF7IP_BD; ATF-interacting protein binding domain
      cl21561
      Location:601 → 851
      7tm_4; Olfactory receptor

    5. NM_001290446.1 → NP_001277375.1  adhesion G-protein coupled receptor G2 isoform 6 precursor

      See identical proteins and their annotated locations for NP_001277375.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (6) uses an alternate in-frame splice site, compared to variant 1. The encoded isoform (6) is shorter than isoform 1.
      Source sequence(s)
      AL731801, BC115874, BY769670
      Consensus CDS
      CCDS72459.1
      UniProtKB/TrEMBL
      A2AHQ2
      Related
      ENSMUSP00000108027.3, ENSMUST00000112408.9
      Conserved Domains (4) summary
      cd15444
      Location:614 → 883
      7tmB2_GPR64; orphan adhesion receptor GPR64 and related proteins, member of subfamily B2 of the class B secretin-like receptors of seven-transmembrane G protein-coupled receptors
      pfam01825
      Location:558 → 601
      GPS; GPCR proteolysis site, GPS, motif
      pfam03154
      Location:210 → 483
      Atrophin-1; Atrophin-1 family
      NF033913
      Location:236 → 356
      fibronec_FbpA; LPXTG-anchored fibronectin-binding protein FbpA

    6. NM_178712.4 → NP_848827.1  adhesion G-protein coupled receptor G2 isoform 1 precursor

      See identical proteins and their annotated locations for NP_848827.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AL731801, BC116644, BY769670
      Consensus CDS
      CCDS41196.1
      UniProtKB/Swiss-Prot
      A2AHP8, A2AHP9, A2AHQ0, A2AHQ3, Q8BL10, Q8CJ08, Q8CJ09, Q8CJ10, Q8CJ12
      UniProtKB/TrEMBL
      A2AHQ2, Q14AX7
      Related
      ENSMUSP00000108019.2, ENSMUST00000112400.8
      Conserved Domains (4) summary
      cd15444
      Location:617 → 886
      7tmB2_GPR64; orphan adhesion receptor GPR64 and related proteins, member of subfamily B2 of the class B secretin-like receptors of seven-transmembrane G protein-coupled receptors
      pfam01825
      Location:561 → 604
      GPS; GPCR proteolysis site, GPS, motif
      pfam03154
      Location:213 → 486
      Atrophin-1; Atrophin-1 family
      NF033913
      Location:239 → 359
      fibronec_FbpA; LPXTG-anchored fibronectin-binding protein FbpA

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000086.8 Reference GRCm39 C57BL/6J

      Range
      159173315..159281072
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011247817.4 → XP_011246119.1  adhesion G-protein coupled receptor G2 isoform X10

      See identical proteins and their annotated locations for XP_011246119.1

      UniProtKB/TrEMBL
      A2AHQ2
      Conserved Domains (4) summary
      cd15444
      Location:624 → 893
      7tmB2_GPR64; orphan adhesion receptor GPR64 and related proteins, member of subfamily B2 of the class B secretin-like receptors of seven-transmembrane G protein-coupled receptors
      pfam01825
      Location:561 → 611
      GPS; GPCR proteolysis site, GPS, motif
      pfam03154
      Location:213 → 486
      Atrophin-1; Atrophin-1 family
      NF033913
      Location:239 → 359
      fibronec_FbpA; LPXTG-anchored fibronectin-binding protein FbpA

    2. XM_017318479.3 → XP_017173968.1  adhesion G-protein coupled receptor G2 isoform X10

      UniProtKB/TrEMBL
      A2AHQ2
      Conserved Domains (4) summary
      cd15444
      Location:624 → 893
      7tmB2_GPR64; orphan adhesion receptor GPR64 and related proteins, member of subfamily B2 of the class B secretin-like receptors of seven-transmembrane G protein-coupled receptors
      pfam01825
      Location:561 → 611
      GPS; GPCR proteolysis site, GPS, motif
      pfam03154
      Location:213 → 486
      Atrophin-1; Atrophin-1 family
      NF033913
      Location:239 → 359
      fibronec_FbpA; LPXTG-anchored fibronectin-binding protein FbpA

    3. XM_030251333.2 → XP_030107193.1  adhesion G-protein coupled receptor G2 isoform X24

      UniProtKB/TrEMBL
      A2AHQ2
      Conserved Domains (4) summary
      PRK14948
      Location:275 → 466
      PRK14948; DNA polymerase III subunit gamma/tau
      cd15444
      Location:607 → 876
      7tmB2_GPR64; orphan adhesion receptor GPR64 and related proteins, member of subfamily B2 of the class B secretin-like receptors of seven-transmembrane G protein-coupled receptors
      pfam01825
      Location:544 → 594
      GPS; GPCR proteolysis site, GPS, motif
      pfam03154
      Location:195 → 330
      Atrophin-1; Atrophin-1 family

    4. XM_036161943.1 → XP_036017836.1  adhesion G-protein coupled receptor G2 isoform X23

      UniProtKB/TrEMBL
      A2AHQ2
      Conserved Domains (4) summary
      PHA03369
      Location:236 → 546
      PHA03369; capsid maturational protease; Provisional
      cd15444
      Location:610 → 879
      7tmB2_GPR64; orphan adhesion receptor GPR64 and related proteins, member of subfamily B2 of the class B secretin-like receptors of seven-transmembrane G protein-coupled receptors
      pfam01825
      Location:547 → 597
      GPS; GPCR proteolysis site, GPS, motif
      NF033913
      Location:225 → 345
      fibronec_FbpA; LPXTG-anchored fibronectin-binding protein FbpA

    5. XM_030251334.2 → XP_030107194.1  adhesion G-protein coupled receptor G2 isoform X21

      UniProtKB/TrEMBL
      A2AHQ2
      Conserved Domains (4) summary
      cd15444
      Location:583 → 852
      7tmB2_GPR64; orphan adhesion receptor GPR64 and related proteins, member of subfamily B2 of the class B secretin-like receptors of seven-transmembrane G protein-coupled receptors
      pfam01825
      Location:520 → 570
      GPS; GPCR proteolysis site, GPS, motif
      pfam03154
      Location:172 → 445
      Atrophin-1; Atrophin-1 family
      NF033913
      Location:198 → 318
      fibronec_FbpA; LPXTG-anchored fibronectin-binding protein FbpA

    6. XM_006528824.5 → XP_006528887.1  adhesion G-protein coupled receptor G2 isoform X10

      See identical proteins and their annotated locations for XP_006528887.1

      UniProtKB/TrEMBL
      A2AHQ2
      Conserved Domains (4) summary
      cd15444
      Location:624 → 893
      7tmB2_GPR64; orphan adhesion receptor GPR64 and related proteins, member of subfamily B2 of the class B secretin-like receptors of seven-transmembrane G protein-coupled receptors
      pfam01825
      Location:561 → 611
      GPS; GPCR proteolysis site, GPS, motif
      pfam03154
      Location:213 → 486
      Atrophin-1; Atrophin-1 family
      NF033913
      Location:239 → 359
      fibronec_FbpA; LPXTG-anchored fibronectin-binding protein FbpA

    7. XM_006528827.5 → XP_006528890.1  adhesion G-protein coupled receptor G2 isoform X22

      UniProtKB/TrEMBL
      A2AHQ2
      Conserved Domains (4) summary
      PRK14948
      Location:289 → 480
      PRK14948; DNA polymerase III subunit gamma/tau
      cd15444
      Location:621 → 890
      7tmB2_GPR64; orphan adhesion receptor GPR64 and related proteins, member of subfamily B2 of the class B secretin-like receptors of seven-transmembrane G protein-coupled receptors
      pfam01825
      Location:558 → 608
      GPS; GPCR proteolysis site, GPS, motif
      pfam03154
      Location:209 → 344
      Atrophin-1; Atrophin-1 family

    8. XM_006528829.4 → XP_006528892.1  adhesion G-protein coupled receptor G2 isoform X18

      UniProtKB/TrEMBL
      A2AHQ2
      Conserved Domains (4) summary
      cd15444
      Location:597 → 866
      7tmB2_GPR64; orphan adhesion receptor GPR64 and related proteins, member of subfamily B2 of the class B secretin-like receptors of seven-transmembrane G protein-coupled receptors
      pfam01825
      Location:534 → 584
      GPS; GPCR proteolysis site, GPS, motif
      pfam03154
      Location:186 → 459
      Atrophin-1; Atrophin-1 family
      NF033913
      Location:212 → 332
      fibronec_FbpA; LPXTG-anchored fibronectin-binding protein FbpA

    9. XM_036161933.1 → XP_036017826.1  adhesion G-protein coupled receptor G2 isoform X10

      UniProtKB/TrEMBL
      A2AHQ2
      Conserved Domains (4) summary
      cd15444
      Location:624 → 893
      7tmB2_GPR64; orphan adhesion receptor GPR64 and related proteins, member of subfamily B2 of the class B secretin-like receptors of seven-transmembrane G protein-coupled receptors
      pfam01825
      Location:561 → 611
      GPS; GPCR proteolysis site, GPS, motif
      pfam03154
      Location:213 → 486
      Atrophin-1; Atrophin-1 family
      NF033913
      Location:239 → 359
      fibronec_FbpA; LPXTG-anchored fibronectin-binding protein FbpA

    10. XM_036161939.1 → XP_036017832.1  adhesion G-protein coupled receptor G2 isoform X18

      UniProtKB/TrEMBL
      A2AHQ2
      Conserved Domains (4) summary
      cd15444
      Location:597 → 866
      7tmB2_GPR64; orphan adhesion receptor GPR64 and related proteins, member of subfamily B2 of the class B secretin-like receptors of seven-transmembrane G protein-coupled receptors
      pfam01825
      Location:534 → 584
      GPS; GPCR proteolysis site, GPS, motif
      pfam03154
      Location:186 → 459
      Atrophin-1; Atrophin-1 family
      NF033913
      Location:212 → 332
      fibronec_FbpA; LPXTG-anchored fibronectin-binding protein FbpA

    11. XM_036161934.1 → XP_036017827.1  adhesion G-protein coupled receptor G2 isoform X12

      UniProtKB/Swiss-Prot
      A2AHP8, A2AHP9, A2AHQ0, A2AHQ3, Q8BL10, Q8CJ08, Q8CJ09, Q8CJ10, Q8CJ12
      UniProtKB/TrEMBL
      A2AHQ2, Q14AX7
      Conserved Domains (4) summary
      cd15444
      Location:617 → 886
      7tmB2_GPR64; orphan adhesion receptor GPR64 and related proteins, member of subfamily B2 of the class B secretin-like receptors of seven-transmembrane G protein-coupled receptors
      pfam01825
      Location:561 → 604
      GPS; GPCR proteolysis site, GPS, motif
      pfam03154
      Location:213 → 486
      Atrophin-1; Atrophin-1 family
      NF033913
      Location:239 → 359
      fibronec_FbpA; LPXTG-anchored fibronectin-binding protein FbpA

    12. XM_036161935.1 → XP_036017828.1  adhesion G-protein coupled receptor G2 isoform X13

      UniProtKB/TrEMBL
      A2AHQ2
      Related
      ENSMUSP00000108017.3, ENSMUST00000112398.3
      Conserved Domains (4) summary
      cd15444
      Location:614 → 883
      7tmB2_GPR64; orphan adhesion receptor GPR64 and related proteins, member of subfamily B2 of the class B secretin-like receptors of seven-transmembrane G protein-coupled receptors
      pfam01825
      Location:558 → 601
      GPS; GPCR proteolysis site, GPS, motif
      pfam03154
      Location:210 → 483
      Atrophin-1; Atrophin-1 family
      NF033913
      Location:236 → 356
      fibronec_FbpA; LPXTG-anchored fibronectin-binding protein FbpA

    13. XM_036161942.1 → XP_036017835.1  adhesion G-protein coupled receptor G2 isoform X21

      UniProtKB/TrEMBL
      A2AHQ2
      Conserved Domains (4) summary
      cd15444
      Location:583 → 852
      7tmB2_GPR64; orphan adhesion receptor GPR64 and related proteins, member of subfamily B2 of the class B secretin-like receptors of seven-transmembrane G protein-coupled receptors
      pfam01825
      Location:520 → 570
      GPS; GPCR proteolysis site, GPS, motif
      pfam03154
      Location:172 → 445
      Atrophin-1; Atrophin-1 family
      NF033913
      Location:198 → 318
      fibronec_FbpA; LPXTG-anchored fibronectin-binding protein FbpA

    14. XM_036161937.1 → XP_036017830.1  adhesion G-protein coupled receptor G2 isoform X16

      UniProtKB/TrEMBL
      A2AHQ2
      Conserved Domains (4) summary
      cd15444
      Location:603 → 872
      7tmB2_GPR64; orphan adhesion receptor GPR64 and related proteins, member of subfamily B2 of the class B secretin-like receptors of seven-transmembrane G protein-coupled receptors
      pfam01825
      Location:547 → 590
      GPS; GPCR proteolysis site, GPS, motif
      pfam03154
      Location:199 → 472
      Atrophin-1; Atrophin-1 family
      NF033913
      Location:225 → 345
      fibronec_FbpA; LPXTG-anchored fibronectin-binding protein FbpA

    15. XM_036161938.1 → XP_036017831.1  adhesion G-protein coupled receptor G2 isoform X17

      UniProtKB/TrEMBL
      A2AHQ2, Q14BH6
      Conserved Domains (4) summary
      cd15444
      Location:600 → 869
      7tmB2_GPR64; orphan adhesion receptor GPR64 and related proteins, member of subfamily B2 of the class B secretin-like receptors of seven-transmembrane G protein-coupled receptors
      pfam01825
      Location:544 → 587
      GPS; GPCR proteolysis site, GPS, motif
      pfam03154
      Location:196 → 469
      Atrophin-1; Atrophin-1 family
      NF033913
      Location:222 → 342
      fibronec_FbpA; LPXTG-anchored fibronectin-binding protein FbpA

    16. XM_036161941.1 → XP_036017834.1  adhesion G-protein coupled receptor G2 isoform X20

      UniProtKB/TrEMBL
      A2AHQ2
      Conserved Domains (4) summary
      cd15444
      Location:590 → 859
      7tmB2_GPR64; orphan adhesion receptor GPR64 and related proteins, member of subfamily B2 of the class B secretin-like receptors of seven-transmembrane G protein-coupled receptors
      pfam01825
      Location:534 → 577
      GPS; GPCR proteolysis site, GPS, motif
      pfam03154
      Location:186 → 459
      Atrophin-1; Atrophin-1 family
      NF033913
      Location:212 → 332
      fibronec_FbpA; LPXTG-anchored fibronectin-binding protein FbpA

    17. XM_006528806.3 → XP_006528869.1  adhesion G-protein coupled receptor G2 isoform X1

      UniProtKB/TrEMBL
      A2AHQ2
      Conserved Domains (4) summary
      PRK14948
      Location:368 → 559
      PRK14948; DNA polymerase III subunit gamma/tau
      cd15444
      Location:700 → 969
      7tmB2_GPR64; orphan adhesion receptor GPR64 and related proteins, member of subfamily B2 of the class B secretin-like receptors of seven-transmembrane G protein-coupled receptors
      pfam01825
      Location:637 → 687
      GPS; GPCR proteolysis site, GPS, motif
      pfam03154
      Location:288 → 423
      Atrophin-1; Atrophin-1 family

    18. XM_036161936.1 → XP_036017829.1  adhesion G-protein coupled receptor G2 isoform X15

      UniProtKB/TrEMBL
      A2AHQ2
      Conserved Domains (4) summary
      cd15444
      Location:700 → 969
      7tmB2_GPR64; orphan adhesion receptor GPR64 and related proteins, member of subfamily B2 of the class B secretin-like receptors of seven-transmembrane G protein-coupled receptors
      pfam01825
      Location:637 → 687
      GPS; GPCR proteolysis site, GPS, motif
      pfam03154
      Location:289 → 562
      Atrophin-1; Atrophin-1 family
      NF033913
      Location:315 → 435
      fibronec_FbpA; LPXTG-anchored fibronectin-binding protein FbpA

    19. XM_036161940.1 → XP_036017833.1  adhesion G-protein coupled receptor G2 isoform X19

      UniProtKB/TrEMBL
      A2AHQ2
      Conserved Domains (4) summary
      cd15444
      Location:693 → 962
      7tmB2_GPR64; orphan adhesion receptor GPR64 and related proteins, member of subfamily B2 of the class B secretin-like receptors of seven-transmembrane G protein-coupled receptors
      pfam01825
      Location:637 → 680
      GPS; GPCR proteolysis site, GPS, motif
      pfam03154
      Location:289 → 562
      Atrophin-1; Atrophin-1 family
      NF033913
      Location:315 → 435
      fibronec_FbpA; LPXTG-anchored fibronectin-binding protein FbpA

    20. XM_006528808.4 → XP_006528871.1  adhesion G-protein coupled receptor G2 isoform X3

      UniProtKB/TrEMBL
      A2AHQ2
      Conserved Domains (4) summary
      PRK14948
      Location:368 → 559
      PRK14948; DNA polymerase III subunit gamma/tau
      cd15444
      Location:693 → 962
      7tmB2_GPR64; orphan adhesion receptor GPR64 and related proteins, member of subfamily B2 of the class B secretin-like receptors of seven-transmembrane G protein-coupled receptors
      pfam01825
      Location:637 → 680
      GPS; GPCR proteolysis site, GPS, motif
      pfam03154
      Location:288 → 423
      Atrophin-1; Atrophin-1 family

    21. XM_006528810.4 → XP_006528873.1  adhesion G-protein coupled receptor G2 isoform X5

      UniProtKB/TrEMBL
      A2AHQ2
      Conserved Domains (4) summary
      PRK14948
      Location:354 → 545
      PRK14948; DNA polymerase III subunit gamma/tau
      cd15444
      Location:686 → 955
      7tmB2_GPR64; orphan adhesion receptor GPR64 and related proteins, member of subfamily B2 of the class B secretin-like receptors of seven-transmembrane G protein-coupled receptors
      pfam01825
      Location:623 → 673
      GPS; GPCR proteolysis site, GPS, motif
      pfam03154
      Location:274 → 409
      Atrophin-1; Atrophin-1 family

    22. XM_006528812.4 → XP_006528875.1  adhesion G-protein coupled receptor G2 isoform X7

      UniProtKB/TrEMBL
      A2AHQ2
      Conserved Domains (4) summary
      PRK14948
      Location:354 → 545
      PRK14948; DNA polymerase III subunit gamma/tau
      cd15444
      Location:679 → 948
      7tmB2_GPR64; orphan adhesion receptor GPR64 and related proteins, member of subfamily B2 of the class B secretin-like receptors of seven-transmembrane G protein-coupled receptors
      pfam01825
      Location:623 → 666
      GPS; GPCR proteolysis site, GPS, motif
      pfam03154
      Location:274 → 409
      Atrophin-1; Atrophin-1 family

    23. XM_006528807.4 → XP_006528870.1  adhesion G-protein coupled receptor G2 isoform X2

      UniProtKB/TrEMBL
      A2AHQ2
      Conserved Domains (4) summary
      PRK14948
      Location:365 → 556
      PRK14948; DNA polymerase III subunit gamma/tau
      cd15444
      Location:697 → 966
      7tmB2_GPR64; orphan adhesion receptor GPR64 and related proteins, member of subfamily B2 of the class B secretin-like receptors of seven-transmembrane G protein-coupled receptors
      pfam01825
      Location:634 → 684
      GPS; GPCR proteolysis site, GPS, motif
      pfam03154
      Location:285 → 420
      Atrophin-1; Atrophin-1 family

    24. XM_006528809.4 → XP_006528872.1  adhesion G-protein coupled receptor G2 isoform X4

      UniProtKB/TrEMBL
      A2AHQ2
      Conserved Domains (4) summary
      PRK14948
      Location:365 → 556
      PRK14948; DNA polymerase III subunit gamma/tau
      cd15444
      Location:690 → 959
      7tmB2_GPR64; orphan adhesion receptor GPR64 and related proteins, member of subfamily B2 of the class B secretin-like receptors of seven-transmembrane G protein-coupled receptors
      pfam01825
      Location:634 → 677
      GPS; GPCR proteolysis site, GPS, motif
      pfam03154
      Location:285 → 420
      Atrophin-1; Atrophin-1 family

    25. XM_006528811.4 → XP_006528874.1  adhesion G-protein coupled receptor G2 isoform X6

      UniProtKB/TrEMBL
      A2AHQ2
      Conserved Domains (4) summary
      PRK14948
      Location:351 → 542
      PRK14948; DNA polymerase III subunit gamma/tau
      cd15444
      Location:683 → 952
      7tmB2_GPR64; orphan adhesion receptor GPR64 and related proteins, member of subfamily B2 of the class B secretin-like receptors of seven-transmembrane G protein-coupled receptors
      pfam01825
      Location:620 → 670
      GPS; GPCR proteolysis site, GPS, motif
      pfam03154
      Location:271 → 406
      Atrophin-1; Atrophin-1 family

    26. XM_006528813.4 → XP_006528876.1  adhesion G-protein coupled receptor G2 isoform X8

      UniProtKB/TrEMBL
      A2AHQ2
      Conserved Domains (4) summary
      PRK14948
      Location:351 → 542
      PRK14948; DNA polymerase III subunit gamma/tau
      cd15444
      Location:676 → 945
      7tmB2_GPR64; orphan adhesion receptor GPR64 and related proteins, member of subfamily B2 of the class B secretin-like receptors of seven-transmembrane G protein-coupled receptors
      pfam01825
      Location:620 → 663
      GPS; GPCR proteolysis site, GPS, motif
      pfam03154
      Location:271 → 406
      Atrophin-1; Atrophin-1 family

    27. XM_006528814.4 → XP_006528877.1  adhesion G-protein coupled receptor G2 isoform X9

      UniProtKB/TrEMBL
      A2AHQ2
      Conserved Domains (4) summary
      PRK14948
      Location:341 → 532
      PRK14948; DNA polymerase III subunit gamma/tau
      cd15444
      Location:673 → 942
      7tmB2_GPR64; orphan adhesion receptor GPR64 and related proteins, member of subfamily B2 of the class B secretin-like receptors of seven-transmembrane G protein-coupled receptors
      pfam01825
      Location:610 → 660
      GPS; GPCR proteolysis site, GPS, motif
      pfam03154
      Location:261 → 396
      Atrophin-1; Atrophin-1 family

    28. XM_006528816.4 → XP_006528879.1  adhesion G-protein coupled receptor G2 isoform X11

      UniProtKB/TrEMBL
      A2AHQ2
      Conserved Domains (4) summary
      PRK14948
      Location:341 → 532
      PRK14948; DNA polymerase III subunit gamma/tau
      cd15444
      Location:666 → 935
      7tmB2_GPR64; orphan adhesion receptor GPR64 and related proteins, member of subfamily B2 of the class B secretin-like receptors of seven-transmembrane G protein-coupled receptors
      pfam01825
      Location:610 → 653
      GPS; GPCR proteolysis site, GPS, motif
      pfam03154
      Location:261 → 396
      Atrophin-1; Atrophin-1 family

    29. XM_006528819.4 → XP_006528882.1  adhesion G-protein coupled receptor G2 isoform X14

      UniProtKB/TrEMBL
      A2AHQ2
      Conserved Domains (4) summary
      PRK14948
      Location:327 → 518
      PRK14948; DNA polymerase III subunit gamma/tau
      cd15444
      Location:659 → 928
      7tmB2_GPR64; orphan adhesion receptor GPR64 and related proteins, member of subfamily B2 of the class B secretin-like receptors of seven-transmembrane G protein-coupled receptors
      pfam01825
      Location:596 → 646
      GPS; GPCR proteolysis site, GPS, motif
      pfam03154
      Location:247 → 382
      Atrophin-1; Atrophin-1 family
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8CJ12.1 GenPept UniProtKB/Swiss-Prot:Q8CJ12

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