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    Hif1an hypoxia-inducible factor 1, alpha subunit inhibitor [ Mus musculus (house mouse) ]

    Gene ID: 319594, updated on 23-Jun-2021

    Summary

    Official Symbol
    Hif1anprovided by MGI
    Official Full Name
    hypoxia-inducible factor 1, alpha subunit inhibitorprovided by MGI
    Primary source
    MGI:MGI:2442345
    See related
    Ensembl:ENSMUSG00000036450
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    FI; FIH; FIH1; 2310046M24Rik; A830014H24Rik
    Expression
    Ubiquitous expression in heart adult (RPKM 12.4), CNS E11.5 (RPKM 11.6) and 28 other tissues See more
    Orthologs
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    Genomic context

    See Hif1an in Genome Data Viewer
    Location:
    19; 19 C3
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (44551293..44564713)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (44562854..44576274)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 19 NC_000085.5 (44637344..44650764)

    Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene Sec31 homolog B (S. cerevisiae) Neighboring gene NADH:ubiquinone oxidoreductase subunit B8 Neighboring gene predicted gene, 35460 Neighboring gene predicted gene, 41854

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (3)  1 citation
    • Endonuclease-mediated (1) 

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables 2-oxoglutarate-dependent dioxygenase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables NF-kappaB binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables Notch binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables ankyrin repeat binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables ankyrin repeat binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables carboxylic acid binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables dioxygenase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables ferrous iron binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables hypoxia-inducible factor-asparagine oxygenase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables peptidyl-asparagine 3-dioxygenase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables peptidyl-asparagine 3-dioxygenase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables peptidyl-histidine dioxygenase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables peptidyl-histidine dioxygenase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables zinc ion binding ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    colocalizes_with nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in perinuclear region of cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    hypoxia-inducible factor 1-alpha inhibitor
    Names
    hypoxia-inducible factor asparagine hydroxylase
    NP_795932.2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_176958.3NP_795932.2  hypoxia-inducible factor 1-alpha inhibitor

      See identical proteins and their annotated locations for NP_795932.2

      Status: VALIDATED

      Source sequence(s)
      AC151478, BY122345, BY713373, CN535711
      Consensus CDS
      CCDS29852.1
      UniProtKB/Swiss-Prot
      Q8BLR9
      Related
      ENSMUSP00000035326.5, ENSMUST00000040455.5
      Conserved Domains (1) summary
      pfam13621
      Location:53297
      Cupin_8; Cupin-like domain

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000085.7 Reference GRCm39 C57BL/6J

      Range
      44551293..44564713
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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