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    Ccnj cyclin J [ Mus musculus (house mouse) ]

    Gene ID: 240665, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Ccnjprovided by MGI
    Official Full Name
    cyclin Jprovided by MGI
    Primary source
    MGI:MGI:2443297
    See related
    Ensembl:ENSMUSG00000025010 AllianceGenome:MGI:2443297
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    D430039C20Rik
    Summary
    Predicted to enable cyclin-dependent protein serine/threonine kinase regulator activity. Predicted to be involved in mitotic cell cycle phase transition and regulation of cyclin-dependent protein serine/threonine kinase activity. Predicted to be part of cyclin-dependent protein kinase holoenzyme complex. Predicted to be active in centrosome; cytoplasm; and nucleus. Orthologous to human CCNJ (cyclin J). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 10.4), whole brain E14.5 (RPKM 8.0) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    19 C3; 19 34.26 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (40819345..40837016)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (40830959..40848572)

    Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene ectonucleoside triphosphate diphosphohydrolase 1 Neighboring gene predicted gene, 41846 Neighboring gene coiled-coil and C2 domain containing 2B Neighboring gene STARR-seq mESC enhancer starr_46135 Neighboring gene STARR-positive B cell enhancer mm9_chr19:40895901-40896202 Neighboring gene predicted gene, 33482 Neighboring gene RIKEN cDNA E030044B06 gene Neighboring gene STARR-seq mESC enhancer starr_46136 Neighboring gene predicted gene, 57494 Neighboring gene zinc finger protein 518A Neighboring gene microRNA 8092

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Exploration of the cell-cycle genes found within the RIKEN FANTOM2 data set. Forrest AR, et al. Genome Res, 2003 Jun. PMID 12819135, Free PMC Article
    2. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article
    3. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073
    4. High-efficiency full-length cDNA cloning. Carninci P, et al. Methods Enzymol, 1999. PMID 10349636
    5. RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer. Shibata K, et al. Genome Res, 2000 Nov. PMID 11076861, Free PMC Article

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC118445

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables cyclin-dependent protein serine/threonine kinase regulator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in mitotic cell cycle phase transition IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of cyclin-dependent protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in centrosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of cyclin-dependent protein kinase holoenzyme complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    cyclin-J

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_172839.4 → NP_766427.1  cyclin-J

      See identical proteins and their annotated locations for NP_766427.1

      Status: VALIDATED

      Source sequence(s)
      AC117253
      Consensus CDS
      CCDS29806.1
      UniProtKB/Swiss-Prot
      Q1ED41, Q3TZI6, Q8BIY5
      Related
      ENSMUSP00000025983.7, ENSMUST00000025983.13
      Conserved Domains (2) summary
      cd20528
      Location:34 → 140
      CYCLIN_CCNJ-like_rpt1; first cyclin box found in cyclin-J (CCNJ) family
      cd20529
      Location:145 → 245
      CYCLIN_CCNJ-like_rpt2; second cyclin box found in cyclin-J (CCNJ) family

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000085.7 Reference GRCm39 C57BL/6J

      Range
      40819345..40837016
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036161597.1 → XP_036017490.1  cyclin-J isoform X1

      UniProtKB/Swiss-Prot
      Q1ED41, Q3TZI6, Q8BIY5
      Conserved Domains (2) summary
      cd20528
      Location:34 → 140
      CYCLIN_CCNJ-like_rpt1; first cyclin box found in cyclin-J (CCNJ) family
      cd20529
      Location:145 → 245
      CYCLIN_CCNJ-like_rpt2; second cyclin box found in cyclin-J (CCNJ) family

    2. XM_030250940.1 → XP_030106800.1  cyclin-J isoform X2

      Conserved Domains (2) summary
      pfam00134
      Location:15 → 109
      Cyclin_N; Cyclin, N-terminal domain
      pfam02984
      Location:145 → 284
      Cyclin_C; Cyclin, C-terminal domain

    3. XM_036161596.1 → XP_036017489.1  cyclin-J isoform X1

      UniProtKB/Swiss-Prot
      Q1ED41, Q3TZI6, Q8BIY5
      Conserved Domains (2) summary
      cd20528
      Location:34 → 140
      CYCLIN_CCNJ-like_rpt1; first cyclin box found in cyclin-J (CCNJ) family
      cd20529
      Location:145 → 245
      CYCLIN_CCNJ-like_rpt2; second cyclin box found in cyclin-J (CCNJ) family

    4. XM_006527088.4 → XP_006527151.1  cyclin-J isoform X2

      Conserved Domains (2) summary
      pfam00134
      Location:15 → 109
      Cyclin_N; Cyclin, N-terminal domain
      pfam02984
      Location:145 → 284
      Cyclin_C; Cyclin, C-terminal domain

    5. XM_011247248.3 → XP_011245550.1  cyclin-J isoform X3

      See identical proteins and their annotated locations for XP_011245550.1

      UniProtKB/Swiss-Prot
      Q3TZI6
      Conserved Domains (2) summary
      pfam00134
      Location:15 → 109
      Cyclin_N; Cyclin, N-terminal domain
      pfam02984
      Location:145 → 283
      Cyclin_C; Cyclin, C-terminal domain

    6. XM_017318200.3 → XP_017173689.1  cyclin-J isoform X1

      UniProtKB/Swiss-Prot
      Q1ED41, Q3TZI6, Q8BIY5
      Related
      ENSMUSP00000112643.2, ENSMUST00000119316.2
      Conserved Domains (2) summary
      cd20528
      Location:34 → 140
      CYCLIN_CCNJ-like_rpt1; first cyclin box found in cyclin-J (CCNJ) family
      cd20529
      Location:145 → 245
      CYCLIN_CCNJ-like_rpt2; second cyclin box found in cyclin-J (CCNJ) family

    7. XM_030250941.2 → XP_030106801.1  cyclin-J isoform X3

      Conserved Domains (2) summary
      pfam00134
      Location:15 → 109
      Cyclin_N; Cyclin, N-terminal domain
      pfam02984
      Location:145 → 283
      Cyclin_C; Cyclin, C-terminal domain

    8. XM_036161595.1 → XP_036017488.1  cyclin-J isoform X1

      UniProtKB/Swiss-Prot
      Q1ED41, Q3TZI6, Q8BIY5
      Conserved Domains (2) summary
      cd20528
      Location:34 → 140
      CYCLIN_CCNJ-like_rpt1; first cyclin box found in cyclin-J (CCNJ) family
      cd20529
      Location:145 → 245
      CYCLIN_CCNJ-like_rpt2; second cyclin box found in cyclin-J (CCNJ) family
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q3TZI6.2 GenPept UniProtKB/Swiss-Prot:Q3TZI6

    Gene LinkOut

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