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    Orm3 orosomucoid 3 [ Mus musculus (house mouse) ]

    Gene ID: 18407, updated on 8-Feb-2024

    Summary

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    Official Symbol
    Orm3provided by MGI
    Official Full Name
    orosomucoid 3provided by MGI
    Primary source
    MGI:MGI:97445
    See related
    Ensembl:ENSMUSG00000028359 AllianceGenome:MGI:97445
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Agp-3; Orm-3
    Summary
    Predicted to enable small molecule binding activity. Predicted to be active in extracellular space. Orthologous to human ORM1 (orosomucoid 1) and ORM2 (orosomucoid 2). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in liver adult (RPKM 2.8), subcutaneous fat pad adult (RPKM 2.0) and 7 other tissues See more
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    Genomic context

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    See Orm3 in Genome Data Viewer
    Location:
    4 B3; 4 33.96 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (63274107..63277748)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (63356069..63359506)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene orosomucoid 1 Neighboring gene orosomucoid 1 pseudogene Neighboring gene orosomucoid 2 Neighboring gene AT-hook transcription factor Neighboring gene AT-hook transcription factor, opposite strand

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Differential expression of the mouse alpha 1-acid glycoprotein genes (AGP-1 and AGP-2) during inflammation and aging. Carter KC, et al. Biochim Biophys Acta, 1991 Jun 13. PMID 2054382
    2. The bile acid induced hepatokine orosomucoid suppresses adipocyte differentiation. Lee SH, et al. Biochem Biophys Res Commun, 2021 Jan 1. PMID 33168190, Free PMC Article
    3. A mouse gene family associated with a major submaxillary-gland glycoprotein. Craig AG, et al. Biochem J, 1985 Feb 1. PMID 3977853, Free PMC Article
    4. Evidence for the existence of multiple alpha 1-acid glycoprotein genes in the mouse. Cooper R, et al. J Biol Chem, 1986 Feb 5. PMID 3003086
    5. Structure and expression of mouse alpha 1-acid glycoprotein gene-3 (AGP-3). Chang CJ, et al. DNA Cell Biol, 1992 May. PMID 1605854

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The bile acid induced hepatokine orosomucoid suppresses adipocyte differentiation.
      Title: The bile acid induced hepatokine orosomucoid suppresses adipocyte differentiation.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    enables small molecule binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in extracellular space ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    alpha-1-acid glycoprotein 3
    Names
    AGP 3
    OMD 3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001379520.1 → NP_001366449.1  alpha-1-acid glycoprotein 3 isoform 1 precursor

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AL683828
      UniProtKB/TrEMBL
      B7ZP06, B9EIY6
      Conserved Domains (1) summary
      cd19451
      Location:21 → 195
      lipocalin_AGP-like; alpha1-acid glycoprotein and similar proteins

    2. NM_001379521.1 → NP_001366450.1  alpha-1-acid glycoprotein 3 isoform 3 precursor

      Status: VALIDATED

      Source sequence(s)
      AL683828

    3. NM_013623.3 → NP_038651.2  alpha-1-acid glycoprotein 3 isoform 2 precursor

      See identical proteins and their annotated locations for NP_038651.2

      Status: VALIDATED

      Source sequence(s)
      AL683828
      Consensus CDS
      CCDS18252.1
      UniProtKB/TrEMBL
      B7ZP06, J3JRU4
      Related
      ENSMUSP00000006687.5, ENSMUST00000006687.5
      Conserved Domains (1) summary
      pfam00061
      Location:40 → 180
      Lipocalin; Lipocalin / cytosolic fatty-acid binding protein family

    RNA

    1. NR_166739.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL683828

    2. NR_166740.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL683828

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      63274107..63277748
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006537666.5 → XP_006537729.1  alpha-1-acid glycoprotein 3 isoform X1

      Conserved Domains (1) summary
      cl10502
      Location:21 → 182
      lipocalin_FABP; lipocalin/cytosolic fatty acid-binding protein family

    2. XM_006537669.5 → XP_006537732.1  alpha-1-acid glycoprotein 3 isoform X3

      Conserved Domains (1) summary
      cl10502
      Location:21 → 146
      lipocalin_FABP; lipocalin/cytosolic fatty acid-binding protein family

    3. XM_036163822.1 → XP_036019715.1  alpha-1-acid glycoprotein 3 isoform X4

      UniProtKB/Swiss-Prot
      Q63805
      Conserved Domains (1) summary
      cl10502
      Location:21 → 159
      lipocalin_FABP; lipocalin/cytosolic fatty acid-binding protein family

    4. XM_006537667.4 → XP_006537730.1  alpha-1-acid glycoprotein 3 isoform X2

      Conserved Domains (1) summary
      cl10502
      Location:18 → 162
      lipocalin_FABP; lipocalin/cytosolic fatty acid-binding protein family
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q63805.1 GenPept UniProtKB/Swiss-Prot:Q63805

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