Tnfsf15 tumor necrosis factor (ligand) superfamily, member 15 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Tnfsf15provided by MGI
Official Full Name: tumor necrosis factor (ligand) superfamily, member 15provided by MGI
Primary source: MGI:MGI:2180140
See related: Ensembl:ENSMUSG00000050395 AllianceGenome:MGI:2180140
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Tl1; Tl1a; Vegi; Tnlg1b
Summary: Predicted to enable death receptor binding activity. Predicted to be involved in activation of cysteine-type endopeptidase activity involved in apoptotic process and positive regulation of cytokine production. Predicted to act upstream of or within activation of NF-kappaB-inducing kinase activity. Predicted to be located in plasma membrane. Used to study inflammatory bowel disease 16. Orthologous to human TNFSF15 (TNF superfamily member 15). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Low expression observed in reference dataset See more
Orthologs: human all
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Genomic context

Location:: 4 C1; 4 34.06 cM

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	4	NC_000070.7 (63642837..63663296, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	4	NC_000070.6 (63724600..63745059, complement)

Chromosome 4 - NC_000070.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Roles of tumor necrosis factor-like ligand 1A in gammadeltaT-cell activation and psoriasis pathogenesis.
Title: Roles of tumor necrosis factor-like ligand 1A in γδT-cell activation and psoriasis pathogenesis.
TNFSF15 facilitates the differentiation of CD11b[+] myeloid cells into vascular pericytes in tumors.
Title: TNFSF15 facilitates the differentiation of CD11b(+) myeloid cells into vascular pericytes in tumors.
TL1A promotes the postoperative cognitive dysfunction in mice through NLRP3-mediated A1 differentiation of astrocytes.
Title: TL1A promotes the postoperative cognitive dysfunction in mice through NLRP3-mediated A1 differentiation of astrocytes.
Identification of a novel role for TL1A/DR3 deficiency in acute respiratory distress syndrome that exacerbates alveolar epithelial disruption.
Title: Identification of a novel role for TL1A/DR3 deficiency in acute respiratory distress syndrome that exacerbates alveolar epithelial disruption.
TNFSF15 facilitates differentiation and polarization of macrophages toward M1 phenotype to inhibit tumor growth.
Title: TNFSF15 facilitates differentiation and polarization of macrophages toward M1 phenotype to inhibit tumor growth.
A Protective Role of Tumor Necrosis Factor Superfamily-15 in Intracerebral Hemorrhage-Induced Secondary Brain Injury.
Title: A Protective Role of Tumor Necrosis Factor Superfamily-15 in Intracerebral Hemorrhage-Induced Secondary Brain Injury.
Effect and Mechanism of TL1A Expression on Epithelial-Mesenchymal Transition during Chronic Colitis-Related Intestinal Fibrosis.
Title: Effect and Mechanism of TL1A Expression on Epithelial-Mesenchymal Transition during Chronic Colitis-Related Intestinal Fibrosis.
Tumor necrosis factor ligand-related molecule 1A maintains blood-retinal barrier via modulating SHP-1-Src-VE-cadherin signaling in diabetic retinopathy.
Title: Tumor necrosis factor ligand-related molecule 1A maintains blood-retinal barrier via modulating SHP-1-Src-VE-cadherin signaling in diabetic retinopathy.
Targeting TL1A/DR3 Signaling Offers a Therapeutic Advantage to Neutralizing IL13/IL4Ralpha in Muco-Secretory Fibrotic Disorders.
Title: Targeting TL1A/DR3 Signaling Offers a Therapeutic Advantage to Neutralizing IL13/IL4Rα in Muco-Secretory Fibrotic Disorders.
TL1A regulates adipose-resident innate lymphoid immune responses and enables diet-induced obesity in mice.
Title: TL1A regulates adipose-resident innate lymphoid immune responses and enables diet-induced obesity in mice.

Submit: New GeneRIF Correction See all GeneRIFs (42)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Transgenic (1) 1 citation
Targeted (4) 1 citation
Endonuclease-mediated (5) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables cytokine activity	IEA Inferred from Electronic Annotation more info
enables death receptor binding	ISO Inferred from Sequence Orthology more info
enables tumor necrosis factor receptor binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in activation of cysteine-type endopeptidase activity involved in apoptotic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within activation of cysteine-type endopeptidase activity involved in apoptotic process	ISO Inferred from Sequence Orthology more info	PubMed
acts_upstream_of_or_within cytokine production	ISO Inferred from Sequence Orthology more info	PubMed
involved_in immune response	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of canonical NF-kappaB signal transduction	ISO Inferred from Sequence Orthology more info	PubMed
involved_in positive regulation of cytokine production	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in extracellular space	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info	PubMed

General protein information

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Preferred Names: tumor necrosis factor ligand superfamily member 15

Names: TNF ligand-related molecule 1; bM20K13.3 (tumor necrosis factor (ligand) superfamily, member 15); tumor necrosis factor ligand 1b; vascular endothelial cell growth inhibitor; vascular endothelial growth inhibitor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_177371.4 → NP_796345.4 tumor necrosis factor ligand superfamily member 15

Status: VALIDATED

Source sequence(s)

AL691468

Consensus CDS

CCDS18263.2

UniProtKB/Swiss-Prot

Q5UBV8, Q8K3Y8

UniProtKB/TrEMBL

B2RR33, E9PVT2, F6VXB8

Related

ENSMUSP00000159365.2, ENSMUST00000239480.2

Conserved Domains (1) summary

pfam00229
Location:119 → 252

TNF; TNF(tumor Necrosis Factor) family