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    Il1rn interleukin 1 receptor antagonist [ Mus musculus (house mouse) ]

    Gene ID: 16181, updated on 5-Jul-2021

    Summary

    Official Symbol
    Il1rnprovided by MGI
    Official Full Name
    interleukin 1 receptor antagonistprovided by MGI
    Primary source
    MGI:MGI:96547
    See related
    Ensembl:ENSMUSG00000026981
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    IL; IL-1ra; F630041P17Rik
    Expression
    Broad expression in liver E18 (RPKM 5.5), colon adult (RPKM 5.1) and 18 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Il1rn in Genome Data Viewer
    Location:
    2 A3; 2 16.36 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (24226872..24241503)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (24336860..24351491)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 2 NC_000068.6 (24192380..24207011)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene interleukin 36 receptor antagonist Neighboring gene interleukin 1 family, member 10 Neighboring gene pleckstrin and Sec7 domain containing 4 Neighboring gene paired box 8 Neighboring gene predicted gene 13415

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables cytokine activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables interleukin-1 receptor antagonist activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables interleukin-1 receptor antagonist activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables interleukin-1 receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables interleukin-1 type I receptor antagonist activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables interleukin-1 type II receptor antagonist activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables interleukin-1, type I receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables interleukin-1, type II receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in acute-phase response ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in fever generation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in immune response IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in inflammatory response IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in inflammatory response to antigenic stimulus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acts_upstream_of_or_within insulin secretion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within lipid metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in memory ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of cell migration ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of glutamate secretion ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of heterotypic cell-cell adhesion ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of interleukin-1-mediated signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in negative regulation of interleukin-1-mediated signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of membrane potential ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of JUN kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to glucocorticoid ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in sensory perception of pain ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in extracellular region IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in extracellular space ISO
    Inferred from Sequence Orthology
    more info
     
    located_in vesicle IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    interleukin-1 receptor antagonist protein
    Names
    IL-1RN
    IL1 inhibitor
    IRAP

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001039701.3NP_001034790.1  interleukin-1 receptor antagonist protein isoform 2 precursor

      See identical proteins and their annotated locations for NP_001034790.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate segment compared to variant 3, that removes the translation initiation site. The resulting isoform (2) starts at a downstream AUG and has a shorter and distinct N-terminus compared to isoform 3.
      Source sequence(s)
      AK155641, AL732528
      Consensus CDS
      CCDS38064.1
      UniProtKB/Swiss-Prot
      P25085
      UniProtKB/TrEMBL
      Q542C7
      Related
      ENSMUSP00000110126.2, ENSMUST00000114482.3
      Conserved Domains (1) summary
      smart00125
      Location:34175
      IL1; Interleukin-1 homologues
    2. NM_001159562.1NP_001153034.1  interleukin-1 receptor antagonist protein isoform 3

      See identical proteins and their annotated locations for NP_001153034.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) encodes the longest isoform (3).
      Source sequence(s)
      AL732528, BY206809
      Consensus CDS
      CCDS50520.1
      UniProtKB/TrEMBL
      Q3TBV5
      Related
      ENSMUSP00000110129.3, ENSMUST00000114485.9
      Conserved Domains (1) summary
      smart00125
      Location:18159
      IL1; Interleukin-1 homologues
    3. NM_031167.5NP_112444.1  interleukin-1 receptor antagonist protein isoform 1

      See identical proteins and their annotated locations for NP_112444.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) differs in the 5' UTR and coding sequence compared to variant 3. The resulting isoform (1) has a shorter and distinct N-terminus compared to isoform 3.
      Source sequence(s)
      AK076296, AL732528
      Consensus CDS
      CCDS15736.1
      UniProtKB/Swiss-Prot
      P25085
      UniProtKB/TrEMBL
      Q542W1
      Related
      ENSMUSP00000110131.3, ENSMUST00000114487.9
      Conserved Domains (1) summary
      smart00125
      Location:15156
      IL1; Interleukin-1 homologues

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      24226872..24241503
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006497727.4XP_006497790.1  interleukin-1 receptor antagonist protein isoform X1

      Conserved Domains (1) summary
      smart00125
      Location:1140
      IL1; Interleukin-1 homologues
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