Hdc histidine decarboxylase [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Hdcprovided by MGI
Official Full Name: histidine decarboxylaseprovided by MGI
Primary source: MGI:MGI:96062
See related: Ensembl:ENSMUSG00000027360 AllianceGenome:MGI:96062
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Hdc-a; Hdc-c; Hdc-e; Hdc-s
Summary: Enables histidine decarboxylase activity. Acts upstream of or within histamine biosynthetic process and histidine catabolic process. Predicted to be located in cytosol; dendrite; and neuronal cell body. Predicted to be active in cytoplasm. Is expressed in several structures, including alimentary system; brain; genitourinary system; heart; and respiratory system. Used to study Gilles de la Tourette syndrome. Human ortholog(s) of this gene implicated in Gilles de la Tourette syndrome; asthma; and rhinitis. Orthologous to human HDC (histidine decarboxylase). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in ovary adult (RPKM 49.0), lung adult (RPKM 24.4) and 10 other tissues See more
Orthologs: human all
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Genomic context

Location:: 2 F1; 2 61.76 cM

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	2	NC_000068.8 (126435579..126465942, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	2	NC_000068.7 (126593659..126624025, complement)

Chromosome 2 - NC_000068.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The Hdc GC box is critical for Hdc gene transcription and histamine-mediated anaphylaxis.
Title: The Hdc GC box is critical for Hdc gene transcription and histamine-mediated anaphylaxis.
Short- and Long-Term Social Recognition Memory Are Differentially Modulated by Neuronal Histamine.
Title: Short- and Long-Term Social Recognition Memory Are Differentially Modulated by Neuronal Histamine.
Conditional Deletions of Hdc Confirm Roles of Histamine in Anaphylaxis and Circadian Activity but Not in Autoimmune Encephalomyelitis.
Title: Conditional Deletions of Hdc Confirm Roles of Histamine in Anaphylaxis and Circadian Activity but Not in Autoimmune Encephalomyelitis.
Analysis of Immune Associated Co-Expression Networks Reveals Immune-Related Long Non-Coding RNAs during MI in the Presence and Absence of HDC.
Title: Analysis of Immune Associated Co-Expression Networks Reveals Immune-Related Long Non-Coding RNAs during MI in the Presence and Absence of HDC.
Changes in histidine decarboxylase expression influence extramedullary hematopoiesis in postnatal mice.
Title: Changes in histidine decarboxylase expression influence extramedullary hematopoiesis in postnatal mice.
Histidine decarboxylase deficiency inhibits NBP-induced extramedullary hematopoiesis by modifying bone marrow and spleen microenvironments.
Title: Histidine decarboxylase deficiency inhibits NBP-induced extramedullary hematopoiesis by modifying bone marrow and spleen microenvironments.
Biliary damage and liver fibrosis are ameliorated in a novel mouse model lacking l-histidine decarboxylase/histamine signaling.
Title: Biliary damage and liver fibrosis are ameliorated in a novel mouse model lacking l-histidine decarboxylase/histamine signaling.
Hdc mutant mice show abnormal behavior, striatal dopamine turnover and opioid peptide gene expression.
Title: Abnormal behavior, striatal dopamine turnover and opioid peptide gene expression in histamine-deficient mice.
Hdc(-/-) high-fat diet (HFD) mice had increased steatosis compared with WT HFD mice. WT HFD mice had increased biliary mass, biliary proliferation, senescence, fibrosis, and hepatic stellate cell activation, which were reduced in Hdc(-/-) HFD mice. In Hdc(-/-) HFD mice, serum leptin levels increased, whereas biliary Ob-R expression decreased.
Title: Knockout of l-Histidine Decarboxylase Prevents Cholangiocyte Damage and Hepatic Fibrosis in Mice Subjected to High-Fat Diet Feeding via Disrupted Histamine/Leptin Signaling.
The results of this study indicated that Hdc deficiency in mice does not disturb the development of striatal and cortical interneurons and does not lead to the morphological and cytological phenotypes characterized by humans with Guilles de la Tourette syndrome.
Title: Behavioral and stereological characterization of Hdc KO mice: Relation to Tourette syndrome.

Submit: New GeneRIF Correction See all GeneRIFs (40)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (8) 1 citation
Targeted (7) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AW108189 (e-PCR)
- UniSTS:178699

Hdc-c (e-PCR), detects polymorphism
- UniSTS:164923

D2Mit256 (e-PCR), detects polymorphism
- UniSTS:129137

PMC101357P1 (e-PCR)
- UniSTS:270061

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables amino acid binding	ISO Inferred from Sequence Orthology more info
enables carbon-carbon lyase activity	IEA Inferred from Electronic Annotation more info
enables carboxy-lyase activity	IEA Inferred from Electronic Annotation more info
enables histidine decarboxylase activity	IBA Inferred from Biological aspect of Ancestor more info
enables histidine decarboxylase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables histidine decarboxylase activity	ISO Inferred from Sequence Orthology more info
enables histidine decarboxylase activity	TAS Traceable Author Statement more info	PubMed
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables lyase activity	IEA Inferred from Electronic Annotation more info
enables pyridoxal phosphate binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in amino acid metabolic process	IEA Inferred from Electronic Annotation more info
involved_in carboxylic acid metabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within catecholamine biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in histamine biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within histamine biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in histamine biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in histamine metabolic process	ISO Inferred from Sequence Orthology more info
involved_in histidine catabolic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within histidine catabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in histidine catabolic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within histidine catabolic process	TAS Traceable Author Statement more info	PubMed
involved_in histidine metabolic process	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in dendrite	ISO Inferred from Sequence Orthology more info
located_in neuronal cell body	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: histidine decarboxylase

Names: L-histidine decarboxylase

NP_032256.3

EC 4.1.1.22

XP_006498847.1

EC 4.1.1.22

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_008230.6 → NP_032256.3 histidine decarboxylase

See identical proteins and their annotated locations for NP_032256.3

Status: VALIDATED

Source sequence(s)

AK133455, AV249910, BQ176022

Consensus CDS

CCDS16684.1

UniProtKB/Swiss-Prot

P23738, Q9QWU3

UniProtKB/TrEMBL

Q7TMW5

Related

ENSMUSP00000028838.5, ENSMUST00000028838.5

Conserved Domains (1) summary

pfam00282
Location:43 → 421

Pyridoxal_deC; Pyridoxal-dependent decarboxylase conserved domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000068.8 Reference GRCm39 C57BL/6J

Range

126435579..126465942 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006498784.4 → XP_006498847.1 histidine decarboxylase isoform X1

UniProtKB/TrEMBL

Q7TMW5

Conserved Domains (1) summary

pfam00282
Location:62 → 440

Pyridoxal_deC; Pyridoxal-dependent decarboxylase conserved domain