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    Mat2b methionine adenosyltransferase 2 non-catalytic beta subunit methionine [ Mus musculus (house mouse) ]

    Gene ID: 108645, updated on 16-Apr-2024

    Summary

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    Official Symbol
    Mat2bprovided by MGI
    Official Full Name
    methionine adenosyltransferase 2 non-catalytic beta subunit methionineprovided by MGI
    Primary source
    MGI:MGI:1913667
    See related
    Ensembl:ENSMUSG00000042032 AllianceGenome:MGI:1913667
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    TGR; MAT-II; MATIIbeta; 1110064C04Rik; 2410018D16Rik
    Summary
    Predicted to enable enzyme binding activity and methionine adenosyltransferase regulator activity. Predicted to be involved in S-adenosylmethionine biosynthetic process. Predicted to act upstream of or within one-carbon metabolic process. Located in mitochondrion. Is expressed in several structures, including brain; genitourinary system; limb; nose; and respiratory system. Orthologous to human MAT2B (methionine adenosyltransferase 2B). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in cortex adult (RPKM 34.1), bladder adult (RPKM 28.8) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    11 A5; 11 24.4 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (40570141..40586030, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (40679314..40695203, complement)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_29228 Neighboring gene eukaryotic translation initiation factor 4A1 pseudogene Neighboring gene aldo-keto reductase family 1, member B3 pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E6966 Neighboring gene hyaluronan mediated motility receptor (RHAMM) Neighboring gene STARR-seq mESC enhancer starr_29231 Neighboring gene STARR-seq mESC enhancer starr_29232 Neighboring gene NudC domain containing 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Methionine Adenosyltransferase 2β Participates in Mouse Oocyte Maturation by Regulating the MAPK Pathway. An Q, et al. Reprod Sci, 2020 Jan. PMID 32046373
    2. Increased miR-21-3p in Injured Brain Microvascular Endothelial Cells after Traumatic Brain Injury Aggravates Blood-Brain Barrier Damage by Promoting Cellular Apoptosis and Inflammation through Targeting MAT2B. Ge X, et al. J Neurotrauma, 2019 Apr 15. PMID 29695199
    3. Methionine adenosyltransferase 2A regulates mouse zygotic genome activation and morula to blastocyst transition†. Sun H, et al. Biol Reprod, 2019 Mar 1. PMID 30265288
    4. Cloning, expression, and functional characterization of the beta regulatory subunit of human methionine adenosyltransferase (MAT II). LeGros HL Jr, et al. J Biol Chem, 2000 Jan 28. PMID 10644686
    5. Betaine-homocysteine S-methyltransferase deficiency causes increased susceptibility to noise-induced hearing loss associated with plasma hyperhomocysteinemia. Partearroyo T, et al. FASEB J, 2019 May. PMID 30753104, Free PMC Article

    See all (31) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Methionine Adenosyltransferase 2beta Participates in Mouse Oocyte Maturation by Regulating the MAPK Pathway.
      Title: Methionine Adenosyltransferase 2β Participates in Mouse Oocyte Maturation by Regulating the MAPK Pathway.
    2. Increased miR-21-3p in Injured Brain Microvascular Endothelial Cells after Traumatic Brain Injury Aggravates Blood-Brain Barrier Damage by Promoting Cellular Apoptosis and Inflammation through Targeting MAT2B.
      Title: Increased miR-21-3p in Injured Brain Microvascular Endothelial Cells after Traumatic Brain Injury Aggravates Blood-Brain Barrier Damage by Promoting Cellular Apoptosis and Inflammation through Targeting MAT2B.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables enzyme binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables methionine adenosyltransferase regulator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables methionine adenosyltransferase regulator activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in S-adenosylmethionine biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in S-adenosylmethionine biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within one-carbon metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of methionine adenosyltransferase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of methionine adenosyltransferase complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrion HDA PubMed 
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    methionine adenosyltransferase 2 subunit beta
    Names
    MAT II beta
    methionine adenosyltransferase 2 beta subunit
    methionine adenosyltransferase II, beta
    NP_001186203.1
    NP_598778.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001199274.1 → NP_001186203.1  methionine adenosyltransferase 2 subunit beta isoform 2

      See identical proteins and their annotated locations for NP_001186203.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) contains an alternate first exon which includes different sequence for the 5' coding region, compared to variant 1. The resulting protein (isoform 2) has a distinct and shorter N-terminus when it is compared to isoform 1.
      Source sequence(s)
      AK075947, BC003457, CA559663
      Consensus CDS
      CCDS56767.1
      UniProtKB/Swiss-Prot
      Q99LB6
      Related
      ENSMUSP00000098901.4, ENSMUST00000101347.10
      Conserved Domains (2) summary
      cd05254
      Location:19 → 305
      dTDP_HR_like_SDR_e; dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs
      pfam04321
      Location:20 → 311
      RmlD_sub_bind; RmlD substrate binding domain

    2. NM_134017.2 → NP_598778.1  methionine adenosyltransferase 2 subunit beta isoform 1

      See identical proteins and their annotated locations for NP_598778.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer protein (isoform a).
      Source sequence(s)
      AL646055, BC003457
      Consensus CDS
      CCDS24547.1
      UniProtKB/Swiss-Prot
      Q5NC89, Q76LX2, Q8BVX6, Q8BYT9, Q99LB6
      Related
      ENSMUSP00000048222.5, ENSMUST00000040167.11
      Conserved Domains (2) summary
      cd05254
      Location:30 → 316
      dTDP_HR_like_SDR_e; dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs
      pfam04321
      Location:31 → 322
      RmlD_sub_bind; RmlD substrate binding domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      40570141..40586030 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q99LB6.1 GenPept UniProtKB/Swiss-Prot:Q99LB6

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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