Trem1 triggering receptor expressed on myeloid cells 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Trem1provided by MGI
Official Full Name: triggering receptor expressed on myeloid cells 1provided by MGI
Primary source: MGI:MGI:1930005
See related: Ensembl:ENSMUSG00000042265 AllianceGenome:MGI:1930005
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary: Predicted to enable scaffold protein binding activity. Acts upstream of or within neutrophil chemotaxis; neutrophil extravasation; and neutrophil-mediated killing of gram-negative bacterium. Predicted to be located in plasma membrane. Predicted to be integral component of membrane. Is expressed in bladder and renal vasculature. Human ortholog(s) of this gene implicated in bacterial pneumonia; bacterial sepsis; malaria; and myocardial infarction. Orthologous to human TREM1 (triggering receptor expressed on myeloid cells 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in testis adult (RPKM 1.2), liver E18 (RPKM 1.1) and 5 other tissues See more
Orthologs: human all
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Genomic context

Location:: 17 C; 17 23.99 cM

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	17	NC_000083.7 (48539763..48553955)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	17	NC_000083.6 (48232713..48246927)

Chromosome 17 - NC_000083.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Systemic neutrophils are triggered by respiratory Bacillus Calmette- Guerin and mediate pulmonary mycobacterial clearance in synergy with the triggering receptor expressed on myeloid cells 1.
Title: Systemic neutrophils are triggered by respiratory Bacillus Calmette- Guérin and mediate pulmonary mycobacterial clearance in synergy with the triggering receptor expressed on myeloid cells 1.
Endothelial TREM-1 receptor regulates the blood-brain barrier integrity after intracerebral hemorrhage in mice via SYK/beta-catenin signaling.
Title: Endothelial TREM-1 receptor regulates the blood-brain barrier integrity after intracerebral hemorrhage in mice via SYK/β-catenin signaling.
Agomir miRNA-150-5p alleviates pristane-induced lupus by suppressing myeloid dendritic cells activation and inflammation via TREM-1 axis.
Title: Agomir miRNA-150-5p alleviates pristane-induced lupus by suppressing myeloid dendritic cells activation and inflammation via TREM-1 axis.
TREM1 activation of myeloid cells promotes antitumor immunity.
Title: TREM1 activation of myeloid cells promotes antitumor immunity.
The microglial innate immune receptors TREM-1 and TREM-2 in the anterior cingulate cortex (ACC) drive visceral hypersensitivity and depressive-like behaviors following DSS-induced colitis.
Title: The microglial innate immune receptors TREM-1 and TREM-2 in the anterior cingulate cortex (ACC) drive visceral hypersensitivity and depressive-like behaviors following DSS-induced colitis.
Inhibition of TREM-1 ameliorates Lipopolysaccharide-induced depressive-like behaviors by alleviating neuroinflammation in the PFC via PI3K/Akt signaling pathway.
Title: Inhibition of TREM-1 ameliorates Lipopolysaccharide-induced depressive-like behaviors by alleviating neuroinflammation in the PFC via PI3K/Akt signaling pathway.
Radiation upregulates macrophage TREM-1 expression to exacerbate injury in mice.
Title: Radiation upregulates macrophage TREM-1 expression to exacerbate injury in mice.
TREM-1 induces pyroptosis in cardiomyocytes by activating NLRP3 inflammasome through the SMC4/NEMO pathway.
Title: TREM-1 induces pyroptosis in cardiomyocytes by activating NLRP3 inflammasome through the SMC4/NEMO pathway.
Triggering receptor expressed on myeloid cells-1 deletion in mice attenuates high-fat diet-induced obesity.
Title: Triggering receptor expressed on myeloid cells-1 deletion in mice attenuates high-fat diet-induced obesity.
TREM-1 governs NLRP3 inflammasome activation of macrophages by firing up glycolysis in acute lung injury.
Title: TREM-1 governs NLRP3 inflammasome activation of macrophages by firing up glycolysis in acute lung injury.

Submit: New GeneRIF Correction See all GeneRIFs (93)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (4) 1 citation
Endonuclease-mediated (4)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables receptor decoy activity	ISO Inferred from Sequence Orthology more info
enables scaffold protein binding	ISO Inferred from Sequence Orthology more info
enables transmembrane signaling receptor activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within adaptive immune response	IEA Inferred from Electronic Annotation more info
involved_in chemokine production	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within chemokine production	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within cytokine production	IGI Inferred from Genetic Interaction more info	PubMed
involved_in cytokine production involved in immune response	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within cytokine production involved in immune response	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within immune system process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within innate immune response	IEA Inferred from Electronic Annotation more info
involved_in neutrophil chemotaxis	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within neutrophil chemotaxis	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within neutrophil extravasation	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within neutrophil migration	IGI Inferred from Genetic Interaction more info	PubMed
involved_in neutrophil-mediated killing of gram-negative bacterium	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within neutrophil-mediated killing of gram-negative bacterium	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of cardiac muscle cell apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell-matrix adhesion	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of macrophage chemotaxis	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in cell surface	ISO Inferred from Sequence Orthology more info
is_active_in extracellular space	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: triggering receptor expressed on myeloid cells 1

Names: triggering receptor expressed in monocytes 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001347399.1 → NP_001334328.1 triggering receptor expressed on myeloid cells 1 isoform 2 precursor

Status: VALIDATED

Source sequence(s)

AC241601

Consensus CDS

CCDS84319.1

UniProtKB/TrEMBL

Q14DT9

Related

ENSMUSP00000108877.4, ENSMUST00000113251.10
NM_021406.5 → NP_067381.1 triggering receptor expressed on myeloid cells 1 isoform 1 precursor

See identical proteins and their annotated locations for NP_067381.1

Status: VALIDATED

Source sequence(s)

AC241601, AK089439

Consensus CDS

CCDS28860.1

UniProtKB/Swiss-Prot

Q3TAL7, Q9JKE2

Related

ENSMUSP00000038636.7, ENSMUST00000048782.7

Conserved Domains (2) summary

smart00410
Location:32 → 133

IG_like; Immunoglobulin like

pfam07686
Location:32 → 134

V-set; Immunoglobulin V-set domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000083.7 Reference GRCm39 C57BL/6J

Range

48539763..48553955

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006524729.5 → XP_006524792.1 triggering receptor expressed on myeloid cells 1 isoform X3

Conserved Domains (1) summary

pfam07686
Location:32 → 134

V-set; Immunoglobulin V-set domain
XM_036160714.1 → XP_036016607.1 triggering receptor expressed on myeloid cells 1 isoform X1

Conserved Domains (2) summary

cd00096
Location:28 → 33

Ig; Ig strand A' [structural motif]

cl11960
Location:25 → 132

Ig; Immunoglobulin domain
XM_006524728.4 → XP_006524791.1 triggering receptor expressed on myeloid cells 1 isoform X2

See identical proteins and their annotated locations for XP_006524791.1

Conserved Domains (1) summary

pfam07686
Location:1 → 89

V-set; Immunoglobulin V-set domain
XM_006524726.5 → XP_006524789.1 triggering receptor expressed on myeloid cells 1 isoform X2

See identical proteins and their annotated locations for XP_006524789.1

Conserved Domains (1) summary

pfam07686
Location:1 → 89

V-set; Immunoglobulin V-set domain