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    Tsen34 tRNA splicing endonuclease subunit 34 [ Mus musculus (house mouse) ]

    Gene ID: 66078, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Tsen34provided by MGI
    Official Full Name
    tRNA splicing endonuclease subunit 34provided by MGI
    Primary source
    MGI:MGI:1913328
    See related
    Ensembl:ENSMUSG00000035585 AllianceGenome:MGI:1913328
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Leng5; 0610027F08Rik
    Summary
    Predicted to enable tRNA-intron endonuclease activity. Predicted to be involved in tRNA-type intron splice site recognition and cleavage. Predicted to act upstream of or within mRNA processing and tRNA processing. Predicted to be located in nucleoplasm. Predicted to be part of tRNA-intron endonuclease complex. Human ortholog(s) of this gene implicated in pontocerebellar hypoplasia type 2C. Orthologous to human TSEN34 (tRNA splicing endonuclease subunit 34). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in adrenal adult (RPKM 57.5), ovary adult (RPKM 44.9) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    7 A1; 7 2.13 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (3696300..3704033)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (3693087..3701035)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene leukocyte receptor cluster (LRC) member 1 Neighboring gene transmembrane channel-like gene family 4 Neighboring gene membrane bound O-acyltransferase domain containing 7 Neighboring gene STARR-positive B cell enhancer ABC_E2812 Neighboring gene ribosomal protein S9 Neighboring gene paired Ig-like receptor B

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Overview of inactivating mutations in the protein-coding genome of the mouse reference strain C57BL/6J. Timmermans S, et al. JCI Insight, 2018 Jul 12. PMID 29997285, Free PMC Article
    2. Protein-protein interaction panel using mouse full-length cDNAs. Suzuki H, et al. Genome Res, 2001 Oct. PMID 11591653, Free PMC Article
    3. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article
    4. Fancd2 in vivo interaction network reveals a non-canonical role in mitochondrial function. Zhang T, et al. Sci Rep, 2017 Apr 5. PMID 28378742, Free PMC Article
    5. Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas. Watahiki A, et al. Nat Methods, 2004 Dec. PMID 15782199

    See all (20) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables lyase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables tRNA-intron endonuclease activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within mRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within tRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in tRNA splicing, via endonucleolytic cleavage and ligation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in tRNA-type intron splice site recognition and cleavage IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of tRNA-intron endonuclease complex IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    tRNA-splicing endonuclease subunit Sen34
    Names
    leukocyte receptor cluster (LRC) member 5
    leukocyte receptor cluster member 5 homolog
    tRNA splicing endonuclease 34 homolog
    tRNA-intron endonuclease Sen34
    NP_001157676.1
    NP_001157677.1
    NP_001406977.1
    NP_001406980.1
    NP_001406981.1
    NP_001406982.1
    NP_001406983.1
    NP_001406984.1
    NP_001406985.1
    NP_001406986.1
    NP_001406987.1
    NP_001406989.1
    NP_001406990.1
    NP_001406991.1
    NP_077130.1
    XP_006540343.2
    XP_017167711.2
    XP_017167713.1
    XP_017167714.1
    XP_017167715.1
    XP_036009227.1
    XP_036009228.1
    XP_036009230.1
    XP_036009231.1
    XP_036009232.1
    XP_036009233.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001164204.2 → NP_001157676.1  tRNA-splicing endonuclease subunit Sen34 isoform a

      See identical proteins and their annotated locations for NP_001157676.1

      Status: VALIDATED

      Source sequence(s)
      AC171680
      Consensus CDS
      CCDS20725.1
      UniProtKB/Swiss-Prot
      Q58EU2, Q8BMZ5, Q99LV6, Q9CYW1
      Related
      ENSMUSP00000104270.2, ENSMUST00000108630.8
      Conserved Domains (2) summary
      pfam03985
      Location:98 → 170
      Paf1
      pfam01974
      Location:223 → 307
      tRNA_int_endo; tRNA intron endonuclease, catalytic C-terminal domain

    2. NM_001164205.2 → NP_001157677.1  tRNA-splicing endonuclease subunit Sen34 isoform b

      See identical proteins and their annotated locations for NP_001157677.1

      Status: VALIDATED

      Source sequence(s)
      AC171680
      Consensus CDS
      CCDS51966.1
      UniProtKB/Swiss-Prot
      Q8BMZ5
      UniProtKB/TrEMBL
      Q9CWG3
      Related
      ENSMUSP00000104269.2, ENSMUST00000108629.8
      Conserved Domains (1) summary
      pfam01974
      Location:223 → 278
      tRNA_int_endo; tRNA intron endonuclease, catalytic C-terminal domain

    3. NM_001420048.1 → NP_001406977.1  tRNA-splicing endonuclease subunit Sen34 isoform c

      Status: VALIDATED

      Source sequence(s)
      AC171680

    4. NM_001420051.1 → NP_001406980.1  tRNA-splicing endonuclease subunit Sen34 isoform d

      Status: VALIDATED

      Source sequence(s)
      AC171680

    5. NM_001420052.1 → NP_001406981.1  tRNA-splicing endonuclease subunit Sen34 isoform d

      Status: VALIDATED

      Source sequence(s)
      AC171680

    6. NM_001420053.1 → NP_001406982.1  tRNA-splicing endonuclease subunit Sen34 isoform a

      Status: VALIDATED

      Source sequence(s)
      AC171680
      UniProtKB/Swiss-Prot
      Q58EU2, Q8BMZ5, Q99LV6, Q9CYW1

    7. NM_001420054.1 → NP_001406983.1  tRNA-splicing endonuclease subunit Sen34 isoform a

      Status: VALIDATED

      Source sequence(s)
      AC171680
      UniProtKB/Swiss-Prot
      Q58EU2, Q8BMZ5, Q99LV6, Q9CYW1

    8. NM_001420055.1 → NP_001406984.1  tRNA-splicing endonuclease subunit Sen34 isoform e

      Status: VALIDATED

      Source sequence(s)
      AC171680
      UniProtKB/TrEMBL
      H7BX14

    9. NM_001420056.1 → NP_001406985.1  tRNA-splicing endonuclease subunit Sen34 isoform f

      Status: VALIDATED

      Source sequence(s)
      AC171680

    10. NM_001420057.1 → NP_001406986.1  tRNA-splicing endonuclease subunit Sen34 isoform f

      Status: VALIDATED

      Source sequence(s)
      AC171680

    11. NM_001420058.1 → NP_001406987.1  tRNA-splicing endonuclease subunit Sen34 isoform g

      Status: VALIDATED

      Source sequence(s)
      AC171680
      UniProtKB/TrEMBL
      A0A0U1RPF7

    12. NM_001420060.1 → NP_001406989.1  tRNA-splicing endonuclease subunit Sen34 isoform g

      Status: VALIDATED

      Source sequence(s)
      AC171680
      UniProtKB/TrEMBL
      A0A0U1RPF7

    13. NM_001420061.1 → NP_001406990.1  tRNA-splicing endonuclease subunit Sen34 isoform h

      Status: VALIDATED

      Source sequence(s)
      AC171680

    14. NM_001420062.1 → NP_001406991.1  tRNA-splicing endonuclease subunit Sen34 isoform h

      Status: VALIDATED

      Source sequence(s)
      AC171680

    15. NM_024168.3 → NP_077130.1  tRNA-splicing endonuclease subunit Sen34 isoform a

      See identical proteins and their annotated locations for NP_077130.1

      Status: VALIDATED

      Source sequence(s)
      AC171680
      Consensus CDS
      CCDS20725.1
      UniProtKB/Swiss-Prot
      Q58EU2, Q8BMZ5, Q99LV6, Q9CYW1
      Related
      ENSMUSP00000104267.4, ENSMUST00000108627.4
      Conserved Domains (2) summary
      pfam03985
      Location:98 → 170
      Paf1
      pfam01974
      Location:223 → 307
      tRNA_int_endo; tRNA intron endonuclease, catalytic C-terminal domain

    RNA

    1. NR_185127.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC171680

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      3696300..3704033
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017312222.3 → XP_017167711.2  tRNA-splicing endonuclease subunit Sen34 isoform X4

      Conserved Domains (1) summary
      pfam01974
      Location:264 → 348
      tRNA_int_endo; tRNA intron endonuclease, catalytic C-terminal domain

    2. XM_017312224.3 → XP_017167713.1  tRNA-splicing endonuclease subunit Sen34 isoform X5

      UniProtKB/Swiss-Prot
      Q58EU2, Q8BMZ5, Q99LV6, Q9CYW1
      Conserved Domains (2) summary
      pfam03985
      Location:98 → 170
      Paf1
      pfam01974
      Location:223 → 307
      tRNA_int_endo; tRNA intron endonuclease, catalytic C-terminal domain

    3. XM_036153335.1 → XP_036009228.1  tRNA-splicing endonuclease subunit Sen34 isoform X3

      Conserved Domains (1) summary
      cd22363
      Location:224 → 256
      tRNA-intron_lyase_C; catalytic C-terminal domain of the tRNA-intron lyase

    4. XM_036153338.1 → XP_036009231.1  tRNA-splicing endonuclease subunit Sen34 isoform X3

      Conserved Domains (1) summary
      cd22363
      Location:224 → 256
      tRNA-intron_lyase_C; catalytic C-terminal domain of the tRNA-intron lyase

    5. XM_036153337.1 → XP_036009230.1  tRNA-splicing endonuclease subunit Sen34 isoform X3

      Conserved Domains (1) summary
      cd22363
      Location:224 → 256
      tRNA-intron_lyase_C; catalytic C-terminal domain of the tRNA-intron lyase

    6. XM_006540280.5 → XP_006540343.2  tRNA-splicing endonuclease subunit Sen34 isoform X2

      Conserved Domains (1) summary
      pfam01974
      Location:247 → 331
      tRNA_int_endo; tRNA intron endonuclease, catalytic C-terminal domain

    7. XM_017312225.3 → XP_017167714.1  tRNA-splicing endonuclease subunit Sen34 isoform X5

      UniProtKB/Swiss-Prot
      Q58EU2, Q8BMZ5, Q99LV6, Q9CYW1
      Conserved Domains (2) summary
      pfam03985
      Location:98 → 170
      Paf1
      pfam01974
      Location:223 → 307
      tRNA_int_endo; tRNA intron endonuclease, catalytic C-terminal domain

    8. XM_017312226.3 → XP_017167715.1  tRNA-splicing endonuclease subunit Sen34 isoform X5

      UniProtKB/Swiss-Prot
      Q58EU2, Q8BMZ5, Q99LV6, Q9CYW1
      Conserved Domains (2) summary
      pfam03985
      Location:98 → 170
      Paf1
      pfam01974
      Location:223 → 307
      tRNA_int_endo; tRNA intron endonuclease, catalytic C-terminal domain

    9. XM_036153334.1 → XP_036009227.1  tRNA-splicing endonuclease subunit Sen34 isoform X1

      Conserved Domains (1) summary
      cd22363
      Location:248 → 280
      tRNA-intron_lyase_C; catalytic C-terminal domain of the tRNA-intron lyase

    10. XM_036153340.1 → XP_036009233.1  tRNA-splicing endonuclease subunit Sen34 isoform X3

      Conserved Domains (1) summary
      cd22363
      Location:224 → 256
      tRNA-intron_lyase_C; catalytic C-terminal domain of the tRNA-intron lyase

    11. XM_036153339.1 → XP_036009232.1  tRNA-splicing endonuclease subunit Sen34 isoform X3

      Conserved Domains (1) summary
      cd22363
      Location:224 → 256
      tRNA-intron_lyase_C; catalytic C-terminal domain of the tRNA-intron lyase

    RNA

    1. XR_003946537.1 RNA Sequence

    2. XR_003946540.2 RNA Sequence

    3. XR_003946539.2 RNA Sequence

    4. XR_001777993.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8BMZ5.2 GenPept UniProtKB/Swiss-Prot:Q8BMZ5

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