Tspo2 translocator protein 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Tspo2provided by MGI
Official Full Name: translocator protein 2provided by MGI
Primary source: MGI:MGI:1917276
See related: Ensembl:ENSMUSG00000023995 AllianceGenome:MGI:1917276
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Bzrpl1; 2510027D20Rik
Summary: Enables cholesterol binding activity. Involved in enucleate erythrocyte differentiation; intracellular cholesterol transport; and lipid droplet organization. Located in endoplasmic reticulum. Is expressed in several structures, including jaw; liver; skeleton; and spleen. Orthologous to human TSPO2 (translocator protein 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in liver E14.5 (RPKM 59.7), liver E14 (RPKM 47.7) and 2 other tissues See more
Orthologs: human all
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Genomic context

Location:: 17 C; 17 24.12 cM

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	17	NC_000083.7 (48754970..48758592, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	17	NC_000083.6 (48447942..48451564, complement)

Chromosome 17 - NC_000083.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Cholesterol-binding protein TSPO2 coordinates maturation and proliferation of terminally differentiating erythroblasts.
Title: Cholesterol-binding protein TSPO2 coordinates maturation and proliferation of terminally differentiating erythroblasts.
identify the TSPO2 family of proteins as mediators of cholesterol redistribution-dependent erythroblast maturation during mammalian erythropoiesis
Title: Translocator protein 2 is involved in cholesterol redistribution during erythropoiesis.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2) 1 citation

General gene information

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Markers

NoName (e-PCR)
- UniSTS:493096

Tspo2 (e-PCR), detects polymorphism
- UniSTS:528244

NoName (e-PCR)
- UniSTS:487915

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables 5-aminolevulinic acid transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables cholesterol binding	IBA Inferred from Biological aspect of Ancestor more info
enables cholesterol binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in 5-aminolevulinic acid import across plasma membrane	ISO Inferred from Sequence Orthology more info
involved_in enucleate erythrocyte differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in import across plasma membrane	ISO Inferred from Sequence Orthology more info
involved_in intracellular cholesterol transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in lipid droplet organization	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in endoplasmic reticulum	IBA Inferred from Biological aspect of Ancestor more info
located_in endoplasmic reticulum	IDA Inferred from Direct Assay more info	PubMed
is_active_in membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in organelle membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: translocator protein 2

Names: benzodiazapine receptor, peripheral-like 1; peripheral-type benzodiazepine receptor-like protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_027292.2 → NP_081568.1 translocator protein 2

See identical proteins and their annotated locations for NP_081568.1

Status: PROVISIONAL

Source sequence(s)

AK011003

Consensus CDS

CCDS28869.1

UniProtKB/Swiss-Prot

Q9CRZ8

UniProtKB/TrEMBL

E0CX84

Related

ENSMUSP00000024794.6, ENSMUST00000024794.12

Conserved Domains (1) summary

pfam03073
Location:10 → 153

TspO_MBR; TspO/MBR family

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000083.7 Reference GRCm39 C57BL/6J

Range

48754970..48758592 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017317631.2 → XP_017173120.1 translocator protein 2 isoform X1

UniProtKB/Swiss-Prot

Q9CRZ8

UniProtKB/TrEMBL

E0CX84

Conserved Domains (1) summary

pfam03073
Location:10 → 153

TspO_MBR; TspO/MBR family