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    Ttc41 tetratricopeptide repeat domain 41 [ Mus musculus (house mouse) ]

    Gene ID: 103220, updated on 8-Feb-2024

    Summary

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    Official Symbol
    Ttc41provided by MGI
    Official Full Name
    tetratricopeptide repeat domain 41provided by MGI
    Primary source
    MGI:MGI:2387653
    See related
    Ensembl:ENSMUSG00000044937 AllianceGenome:MGI:2387653
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Gnn
    Summary
    Predicted to be located in cytoplasm. Is expressed in central nervous system and dorsal root ganglion. Orthologous to human TTC41P (tetratricopeptide repeat domain 41, pseudogene). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in heart adult (RPKM 105.6), testis adult (RPKM 7.9) and 1 other tissue See more
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    Genomic context

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    Location:
    10 C1; 10 43.07 cM
    Exon count:
    23
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (86541675..86612708)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (86705811..86776844)

    Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 1810014B01 gene Neighboring gene STARR-seq mESC enhancer starr_27467 Neighboring gene heat shock protein 90, beta (Grp94), member 1 Neighboring gene CapStarr-seq enhancer MGSCv37_chr10:86190323-86190623 Neighboring gene STARR-positive B cell enhancer ABC_E11451 Neighboring gene fatty acid binding protein 3, muscle and heart, pseudogene 1 Neighboring gene STARR-seq mESC enhancer starr_27469 Neighboring gene STARR-positive B cell enhancer mm9_chr10:86240990-86241290 Neighboring gene STARR-positive B cell enhancer mm9_chr10:86241543-86241844 Neighboring gene 5'-nucleotidase domain containing 3 Neighboring gene STARR-positive B cell enhancer ABC_E8356 Neighboring gene stabilin 2 Neighboring gene STARR-seq mESC enhancer starr_27475 Neighboring gene ADNP homeobox 2 pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. The common viral insertion site Evi12 is located in the 5'-noncoding region of Gnn, a novel gene with enhanced expression in two subclasses of human acute myeloid leukemia. van den Akker E, et al. J Virol, 2005 May. PMID 15827139, Free PMC Article
    2. Abnormal epidermal differentiation and impaired epithelial-mesenchymal tissue interactions in mice lacking the retinoblastoma relatives p107 and p130. Ruiz S, et al. Development, 2003 Jun. PMID 12702649
    3. Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Ko MS, et al. Development, 2000 Apr. PMID 10725249
    4. Genome-wide expression profiling of mid-gestation placenta and embryo using a 15,000 mouse developmental cDNA microarray. Tanaka TS, et al. Proc Natl Acad Sci U S A, 2000 Aug 1. PMID 10922068, Free PMC Article
    5. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC40847

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    tetratricopeptide repeat protein 41
    Names
    TPR repeat protein 41
    TPR repeat protein GNN
    grp94-neighboring nucleotidase
    tetratricopeptide repeat protein GNN

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001003910.2 → NP_001003910.2  tetratricopeptide repeat protein 41 isoform 3

      See identical proteins and their annotated locations for NP_001003910.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) represents the longest transcript and it encodes the longest protein (isoform 3).
      Source sequence(s)
      AC152453, AK133195, AK166553, BG072108
      Consensus CDS
      CCDS24098.1
      UniProtKB/Swiss-Prot
      Q3TLE1, Q692V3, Q692V4, Q692V5, Q8K0V5
      UniProtKB/TrEMBL
      F8VPV8
      Related
      ENSMUSP00000075059.7, ENSMUST00000075632.14
      Conserved Domains (1) summary
      pfam13401
      Location:336 → 443
      AAA_22; AAA domain

    2. NM_001003939.2 → NP_001003939.2  tetratricopeptide repeat protein 41 isoform 1

      See identical proteins and their annotated locations for NP_001003939.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) differs in the 5' and 3' UTRs and has multiple coding region differences, compared to variant 3. These differences result in a protein (isoform 1) with a shorter C-terminus compared to isoform 3.
      Source sequence(s)
      AC152453, BC030307
      Consensus CDS
      CCDS24099.1
      UniProtKB/TrEMBL
      A0A0G2LB92
      Related
      ENSMUSP00000062844.8, ENSMUST00000061458.9

    3. NM_153595.3 → NP_705823.3  tetratricopeptide repeat protein 41 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' and 3' UTRs and has multiple coding region differences, compared to variant 3. These differences result in a protein (isoform 2) with a shorter C-terminus compared to isoform 3.
      Source sequence(s)
      AC152453
      Consensus CDS
      CCDS88066.1
      UniProtKB/TrEMBL
      A0A1W2P894
      Related
      ENSMUSP00000151920.2, ENSMUST00000219108.2
      Conserved Domains (2) summary
      smart00382
      Location:336 → 443
      AAA; ATPases associated with a variety of cellular activities
      cl21455
      Location:336 → 443
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000076.7 Reference GRCm39 C57BL/6J

      Range
      86541675..86612708
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006512995.4 → XP_006513058.1  tetratricopeptide repeat protein 41 isoform X1

      See identical proteins and their annotated locations for XP_006513058.1

      UniProtKB/Swiss-Prot
      Q3TLE1, Q692V3, Q692V4, Q692V5, Q8K0V5
      UniProtKB/TrEMBL
      F8VPV8
      Conserved Domains (1) summary
      pfam13401
      Location:336 → 443
      AAA_22; AAA domain

    2. XM_006512997.4 → XP_006513060.1  tetratricopeptide repeat protein 41 isoform X1

      See identical proteins and their annotated locations for XP_006513060.1

      UniProtKB/Swiss-Prot
      Q3TLE1, Q692V3, Q692V4, Q692V5, Q8K0V5
      UniProtKB/TrEMBL
      F8VPV8
      Conserved Domains (1) summary
      pfam13401
      Location:336 → 443
      AAA_22; AAA domain

    3. XM_006512996.4 → XP_006513059.1  tetratricopeptide repeat protein 41 isoform X1

      See identical proteins and their annotated locations for XP_006513059.1

      UniProtKB/Swiss-Prot
      Q3TLE1, Q692V3, Q692V4, Q692V5, Q8K0V5
      UniProtKB/TrEMBL
      F8VPV8
      Conserved Domains (1) summary
      pfam13401
      Location:336 → 443
      AAA_22; AAA domain

    4. XM_006513005.4 → XP_006513068.1  tetratricopeptide repeat protein 41 isoform X6

    5. XM_006513000.5 → XP_006513063.1  tetratricopeptide repeat protein 41 isoform X2

      UniProtKB/Swiss-Prot
      Q3TLE1, Q692V3, Q692V4, Q692V5, Q8K0V5
      Conserved Domains (1) summary
      pfam13401
      Location:336 → 443
      AAA_22; AAA domain

    6. XM_006513001.5 → XP_006513064.1  tetratricopeptide repeat protein 41 isoform X3

      UniProtKB/Swiss-Prot
      Q3TLE1, Q692V3, Q692V4, Q692V5, Q8K0V5
      Conserved Domains (1) summary
      pfam13401
      Location:336 → 443
      AAA_22; AAA domain

    7. XM_006513002.5 → XP_006513065.1  tetratricopeptide repeat protein 41 isoform X4

      UniProtKB/Swiss-Prot
      Q3TLE1, Q692V3, Q692V4, Q692V5, Q8K0V5

    8. XM_006513006.5 → XP_006513069.1  tetratricopeptide repeat protein 41 isoform X8

      Conserved Domains (1) summary
      pfam13401
      Location:336 → 443
      AAA_22; AAA domain

    9. XM_017313758.3 → XP_017169247.1  tetratricopeptide repeat protein 41 isoform X7

      Conserved Domains (1) summary
      pfam13401
      Location:336 → 443
      AAA_22; AAA domain

    10. XM_006513003.5 → XP_006513066.1  tetratricopeptide repeat protein 41 isoform X5

      Conserved Domains (1) summary
      pfam13191
      Location:337 → 443
      AAA_16; AAA ATPase domain

    11. XM_036155456.1 → XP_036011349.1  tetratricopeptide repeat protein 41 isoform X11

      Conserved Domains (1) summary
      smart00382
      Location:336 → 443
      AAA; ATPases associated with a variety of cellular activities

    12. XM_011243258.4 → XP_011241560.1  tetratricopeptide repeat protein 41 isoform X10

      Conserved Domains (1) summary
      pfam13401
      Location:336 → 443
      AAA_22; AAA domain

    13. XM_006512998.4 → XP_006513061.1  tetratricopeptide repeat protein 41 isoform X1

      See identical proteins and their annotated locations for XP_006513061.1

      UniProtKB/Swiss-Prot
      Q3TLE1, Q692V3, Q692V4, Q692V5, Q8K0V5
      UniProtKB/TrEMBL
      F8VPV8
      Conserved Domains (1) summary
      pfam13401
      Location:336 → 443
      AAA_22; AAA domain

    14. XM_006512999.4 → XP_006513062.1  tetratricopeptide repeat protein 41 isoform X1

      See identical proteins and their annotated locations for XP_006513062.1

      UniProtKB/Swiss-Prot
      Q3TLE1, Q692V3, Q692V4, Q692V5, Q8K0V5
      UniProtKB/TrEMBL
      F8VPV8
      Conserved Domains (1) summary
      pfam13401
      Location:336 → 443
      AAA_22; AAA domain

    15. XM_006513007.3 → XP_006513070.1  tetratricopeptide repeat protein 41 isoform X9

    16. XM_006513009.5 → XP_006513072.1  tetratricopeptide repeat protein 41 isoform X12

    17. XM_036155457.1 → XP_036011350.1  tetratricopeptide repeat protein 41 isoform X13

    18. XM_017313760.1 → XP_017169249.1  tetratricopeptide repeat protein 41 isoform X14

    RNA

    1. XR_004936026.1 RNA Sequence

    2. XR_004936019.1 RNA Sequence

    3. XR_004936020.1 RNA Sequence

    4. XR_004936022.1 RNA Sequence

    5. XR_004936028.1 RNA Sequence

    6. XR_004936023.1 RNA Sequence

    7. XR_004936021.1 RNA Sequence

    8. XR_004936024.1 RNA Sequence

    9. XR_004936025.1 RNA Sequence

    10. XR_004936027.1 RNA Sequence

    11. XR_004936015.1 RNA Sequence

    12. XR_004936016.1 RNA Sequence

    13. XR_004936012.1 RNA Sequence

    14. XR_001779398.3 RNA Sequence

    15. XR_004936013.1 RNA Sequence

    16. XR_004936014.1 RNA Sequence

    17. XR_004936017.1 RNA Sequence

    18. XR_004936018.1 RNA Sequence

    19. XR_871676.4 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q692V3.1 GenPept UniProtKB/Swiss-Prot:Q692V3

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