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    Sipa1 signal-induced proliferation associated gene 1 [ Mus musculus (house mouse) ]

    Gene ID: 20469, updated on 21-Apr-2024

    Summary

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    Official Symbol
    Sipa1provided by MGI
    Official Full Name
    signal-induced proliferation associated gene 1provided by MGI
    Primary source
    MGI:MGI:107576
    See related
    Ensembl:ENSMUSG00000056917 AllianceGenome:MGI:107576
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Spa1
    Summary
    Predicted to enable GTPase activator activity and protein C-terminus binding activity. Acts upstream of or within regulation of cell cycle. Predicted to be located in transport vesicle. Predicted to be part of protein-containing complex. Predicted to be active in cytoplasm. Is expressed in several structures, including genitourinary system; heart; immune system; liver; and lung. Used to study chronic myeloid leukemia. Orthologous to human SIPA1 (signal-induced proliferation-associated 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in spleen adult (RPKM 156.5), thymus adult (RPKM 70.0) and 18 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    19 A; 19 4.34 cM
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (5701211..5713758, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (5651185..5663722, complement)

    Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E11011 Neighboring gene K(lysine) acetyltransferase 5 Neighboring gene v-rel reticuloendotheliosis viral oncogene homolog A (avian) Neighboring gene pecanex homolog 3 Neighboring gene microRNA 6987 Neighboring gene STARR-positive B cell enhancer ABC_E4259 Neighboring gene STARR-positive B cell enhancer ABC_E11012 Neighboring gene mitogen-activated protein kinase kinase kinase 11

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Sipa1 deficiency-induced bone marrow niche alterations lead to the initiation of myeloproliferative neoplasm. Xiao P, et al. Blood Adv, 2018 Mar 13. PMID 29514790, Free PMC Article
    2. Sipa1 deficiency unleashes a host-immune mechanism eradicating chronic myelogenous leukemia-initiating cells. Xu Y, et al. Nat Commun, 2018 Mar 2. PMID 29500416, Free PMC Article
    3. Essential role of Rap signal in pre-TCR-mediated beta-selection checkpoint in alphabeta T-cell development. Kometani K, et al. Blood, 2008 Dec 1. PMID 18802005
    4. Rap1 signal controls B cell receptor repertoire and generation of self-reactive B1a cells. Ishida D, et al. Immunity, 2006 Apr. PMID 16618600
    5. Antigen-driven T cell anergy and defective memory T cell response via deregulated Rap1 activation in SPA-1-deficient mice. Ishida D, et al. Proc Natl Acad Sci U S A, 2003 Sep 16. PMID 12958214, Free PMC Article

    See all (35) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Sipa1 loss-induced BM niche alterations likely enable evolution of clonal hematopoiesis to the hematological malignancies.
      Title: Sipa1 deficiency-induced bone marrow niche alterations lead to the initiation of myeloproliferative neoplasm.
    2. Sipa1 deficiency uncovers a host immune mechanism potentially capable of eradicating Bcr-Abl(+) hematopoietic progenitor cells.
      Title: Sipa1 deficiency unleashes a host-immune mechanism eradicating chronic myelogenous leukemia-initiating cells.
    3. afadin regulates the cyclical activation and inactivation of Rap1, Rac1, and RhoA through SPA-1 and ARAP1.
      Title: Regulation by afadin of cyclical activation and inactivation of Rap1, Rac1, and RhoA small G proteins at leading edges of moving NIH3T3 cells.
    4. The binding of Bcr/Abl to Spa-1 may cause aberrant subcellular location of Spa-1 and affect migration of these cells.
      Title: Bcr/Abl P190 interaction with Spa-1, a GTPase activating protein for the small GTPase Rap1.
    5. Sipa1 polymorphism is one of the genetic polymorphisms underlying the metastasis efficiency locus Mtes1.
      Title: Sipa1 is a candidate for underlying the metastasis efficiency modifier locus Mtes1.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (3)  1 citation
    • Endonuclease-mediated (2) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • KIAA4074

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables GTPase activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTPase activator activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in cellular response to water deprivation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in epithelial cell morphogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in establishment of epithelial cell polarity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within regulation of cell cycle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of small GTPase mediated signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in Golgi apparatus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    signal-induced proliferation-associated protein 1
    Names
    GTPase-activating protein Spa-1
    sipa-1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001164480.2 → NP_001157952.1  signal-induced proliferation-associated protein 1

      See identical proteins and their annotated locations for NP_001157952.1

      Status: VALIDATED

      Source sequence(s)
      AC134563
      Consensus CDS
      CCDS29474.1
      UniProtKB/TrEMBL
      E9Q0Y4, Q3UE96, Q3UV58
      Related
      ENSMUSP00000128208.2, ENSMUST00000164304.9
      Conserved Domains (4) summary
      PHA03378
      Location:29 → 112
      PHA03378; EBNA-3B; Provisional
      COG1196
      Location:901 → 1023
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam00595
      Location:683 → 755
      PDZ; PDZ domain (Also known as DHR or GLGF)
      pfam02145
      Location:347 → 528
      Rap_GAP; Rap/ran-GAP

    2. NM_001164481.2 → NP_001157953.1  signal-induced proliferation-associated protein 1

      See identical proteins and their annotated locations for NP_001157953.1

      Status: VALIDATED

      Source sequence(s)
      AC134563
      Consensus CDS
      CCDS29474.1
      UniProtKB/TrEMBL
      E9Q0Y4, Q3UE96, Q3UV58
      Related
      ENSMUSP00000073618.6, ENSMUST00000071857.13
      Conserved Domains (4) summary
      PHA03378
      Location:29 → 112
      PHA03378; EBNA-3B; Provisional
      COG1196
      Location:901 → 1023
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam00595
      Location:683 → 755
      PDZ; PDZ domain (Also known as DHR or GLGF)
      pfam02145
      Location:347 → 528
      Rap_GAP; Rap/ran-GAP

    3. NM_001164482.2 → NP_001157954.1  signal-induced proliferation-associated protein 1

      See identical proteins and their annotated locations for NP_001157954.1

      Status: VALIDATED

      Source sequence(s)
      AC134563
      Consensus CDS
      CCDS29474.1
      UniProtKB/TrEMBL
      E9Q0Y4, Q3UE96, Q3UV58
      Related
      ENSMUSP00000157692.2, ENSMUST00000237874.2
      Conserved Domains (4) summary
      PHA03378
      Location:29 → 112
      PHA03378; EBNA-3B; Provisional
      COG1196
      Location:901 → 1023
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam00595
      Location:683 → 755
      PDZ; PDZ domain (Also known as DHR or GLGF)
      pfam02145
      Location:347 → 528
      Rap_GAP; Rap/ran-GAP

    4. NM_001164568.2 → NP_001158040.1  signal-induced proliferation-associated protein 1

      See identical proteins and their annotated locations for NP_001158040.1

      Status: VALIDATED

      Source sequence(s)
      AC134563
      Consensus CDS
      CCDS29474.1
      UniProtKB/TrEMBL
      E9Q0Y4, Q3UE96, Q3UV58
      Related
      ENSMUSP00000132345.2, ENSMUST00000169854.2
      Conserved Domains (4) summary
      PHA03378
      Location:29 → 112
      PHA03378; EBNA-3B; Provisional
      COG1196
      Location:901 → 1023
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam00595
      Location:683 → 755
      PDZ; PDZ domain (Also known as DHR or GLGF)
      pfam02145
      Location:347 → 528
      Rap_GAP; Rap/ran-GAP

    5. NM_001403064.1 → NP_001389993.1  signal-induced proliferation-associated protein 1

      Status: VALIDATED

      Source sequence(s)
      AC134563
      UniProtKB/TrEMBL
      E9Q0Y4

    6. NM_001403065.1 → NP_001389994.1  signal-induced proliferation-associated protein 1

      Status: VALIDATED

      Source sequence(s)
      AC134563
      UniProtKB/TrEMBL
      E9Q0Y4

    7. NM_011379.5 → NP_035509.4  signal-induced proliferation-associated protein 1

      See identical proteins and their annotated locations for NP_035509.4

      Status: VALIDATED

      Source sequence(s)
      AC134563
      Consensus CDS
      CCDS29474.1
      UniProtKB/TrEMBL
      E9Q0Y4, Q3UE96, Q3UV58
      Related
      ENSMUSP00000079637.6, ENSMUST00000080824.13
      Conserved Domains (4) summary
      PHA03378
      Location:29 → 112
      PHA03378; EBNA-3B; Provisional
      COG1196
      Location:901 → 1023
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam00595
      Location:683 → 755
      PDZ; PDZ domain (Also known as DHR or GLGF)
      pfam02145
      Location:347 → 528
      Rap_GAP; Rap/ran-GAP

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000085.7 Reference GRCm39 C57BL/6J

      Range
      5701211..5713758 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036161493.1 → XP_036017386.1  signal-induced proliferation-associated protein 1 isoform X1

      UniProtKB/TrEMBL
      E9Q0Y4, Q3UE96, Q3UV58
      Conserved Domains (4) summary
      PHA03378
      Location:29 → 112
      PHA03378; EBNA-3B; Provisional
      COG1196
      Location:901 → 1023
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam00595
      Location:683 → 755
      PDZ; PDZ domain (Also known as DHR or GLGF)
      pfam02145
      Location:347 → 528
      Rap_GAP; Rap/ran-GAP
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P46062.2 GenPept UniProtKB/Swiss-Prot:P46062

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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