Mpig6b megakaryocyte and platelet inhibitory receptor G6b [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Mpig6bprovided by MGI
Official Full Name: megakaryocyte and platelet inhibitory receptor G6bprovided by MGI
Primary source: MGI:MGI:2146995
See related: Ensembl:ENSMUSG00000073414 AllianceGenome:MGI:2146995
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: G6b; Ng31; C6orf25
Summary: Acts upstream of or within blood coagulation; integrin-mediated signaling pathway; and myeloid cell differentiation. Predicted to be located in several cellular components, including Golgi apparatus; endoplasmic reticulum; and nucleoplasm. Predicted to be active in plasma membrane. Orthologous to human MPIG6B (megakaryocyte and platelet inhibitory receptor G6b). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in spleen adult (RPKM 1.4), testis adult (RPKM 1.3) and 19 other tissues See more
Orthologs: human all
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Genomic context

Location:: 17 B1; 17 18.59 cM

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	17	NC_000083.7 (35281669..35285761, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	17	NC_000083.6 (35062693..35066848, complement)

Chromosome 17 - NC_000083.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Uncoupling of G6b-B from Shp1 and Shp2 results in severe macrothrombocytopenia and aberrant platelet function.
Title: Uncoupling ITIM receptor G6b-B from tyrosine phosphatases Shp1 and Shp2 disrupts murine platelet homeostasis.
these findings establish G6b-B as a major inhibitory receptor regulating megakaryocyte activation, function, and platelet production.
Title: Mice lacking the ITIM-containing receptor G6b-B exhibit macrothrombocytopenia and aberrant platelet function.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (3) 1 citation

General gene information

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Markers

NoName (e-PCR)
- UniSTS:237633

AU023871 (e-PCR)
- UniSTS:160647

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in blood coagulation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within blood coagulation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in erythrocyte differentiation	ISO Inferred from Sequence Orthology more info
involved_in integrin-mediated signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within integrin-mediated signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in megakaryocyte development	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within megakaryocyte development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in megakaryocyte differentiation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of signal transduction	ISO Inferred from Sequence Orthology more info
involved_in platelet formation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within platelet formation	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within platelet formation	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in Golgi apparatus	ISO Inferred from Sequence Orthology more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: megakaryocyte and platelet inhibitory receptor G6b

Names: ITIM-receptor G6b-B; immunoreceptor tyrosine-based inhibitory motif (ITIM) containing platelet receptor; protein G6b

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001033221.3 → NP_001028393.1 megakaryocyte and platelet inhibitory receptor G6b isoform 2 precursor

See identical proteins and their annotated locations for NP_001028393.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) lacks two exons in the coding region compared to variant 1. The resulting protein (isoform 2) is shorter but has the same N- and C-termini compared to isoform 1.

Source sequence(s)

AK137516

Consensus CDS

CCDS28676.1

UniProtKB/TrEMBL

D3YVS6

Related

ENSMUSP00000094950.2, ENSMUST00000097337.8

Conserved Domains (1) summary

pfam15096
Location:20 → 165

G6B; G6B family
NM_001191012.1 → NP_001177941.1 megakaryocyte and platelet inhibitory receptor G6b isoform 1 precursor

See identical proteins and their annotated locations for NP_001177941.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).

Source sequence(s)

AK137516, GU269270

Consensus CDS

CCDS57071.1

UniProtKB/Swiss-Prot

D7PDD4

Related

ENSMUSP00000133377.2, ENSMUST00000174190.2

Conserved Domains (1) summary

pfam15096
Location:20 → 242

G6B; G6B family