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    Rtp4 receptor transporter protein 4 [ Mus musculus (house mouse) ]

    Gene ID: 67775, updated on 2-Apr-2024

    Summary

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    Official Symbol
    Rtp4provided by MGI
    Official Full Name
    receptor transporter protein 4provided by MGI
    Primary source
    MGI:MGI:1915025
    See related
    Ensembl:ENSMUSG00000033355 AllianceGenome:MGI:1915025
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Ifrg28; 5830458K16Rik
    Summary
    Predicted to enable olfactory receptor binding activity. Predicted to be involved in defense response to virus; detection of chemical stimulus involved in sensory perception of bitter taste; and establishment of protein localization to membrane. Predicted to be located in membrane. Predicted to be integral component of membrane. Predicted to be active in cytoplasm. Orthologous to human RTP4 (receptor transporter protein 4). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in liver E18 (RPKM 8.8), mammary gland adult (RPKM 5.1) and 26 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    16 B1; 16 14.55 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (23338976..23432972)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (23520219..23614222)

    Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_40441 Neighboring gene receptor transporter protein 1 Neighboring gene STARR-seq mESC enhancer starr_40442 Neighboring gene MBL associated serine protease 1 Neighboring gene VISTA enhancer mm1315 Neighboring gene 60S ribosomal protein L7a pseudogene Neighboring gene STARR-seq mESC enhancer starr_40444 Neighboring gene STARR-seq mESC enhancer starr_40445 Neighboring gene STARR-seq mESC enhancer starr_40448 Neighboring gene ATP-binding cassette, sub-family E (OABP), member 1 pseudogene Neighboring gene predicted gene, 31430

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Receptor Transporter Protein 4 (RTP4) in the Hypothalamus Is Involved in the Development of Antinociceptive Tolerance to Morphine. Fujita W, et al. Biomolecules, 2022 Oct 13. PMID 36291680, Free PMC Article
    2. Regulation of an Opioid Receptor Chaperone Protein, RTP4, by Morphine. Fujita W, et al. Mol Pharmacol, 2019 Jan. PMID 30348895, Free PMC Article
    3. RTP4 inhibits IFN-I response and enhances experimental cerebral malaria and neuropathology. He X, et al. Proc Natl Acad Sci U S A, 2020 Aug 11. PMID 32709745, Free PMC Article
    4. Cell surface targeting of mu-delta opioid receptor heterodimers by RTP4. Décaillot FM, et al. Proc Natl Acad Sci U S A, 2008 Oct 14. PMID 18836069, Free PMC Article
    5. RTP family members induce functional expression of mammalian odorant receptors. Saito H, et al. Cell, 2004 Nov 24. PMID 15550249

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Restriction of SARS-CoV-2 replication by receptor transporter protein 4 (RTP4).
      Title: Restriction of SARS-CoV-2 replication by receptor transporter protein 4 (RTP4).
    2. Receptor Transporter Protein 4 (RTP4) in the Hypothalamus Is Involved in the Development of Antinociceptive Tolerance to Morphine.
      Title: Receptor Transporter Protein 4 (RTP4) in the Hypothalamus Is Involved in the Development of Antinociceptive Tolerance to Morphine.
    3. RTP4 inhibits IFN-I response and enhances experimental cerebral malaria and neuropathology.
      Title: RTP4 inhibits IFN-I response and enhances experimental cerebral malaria and neuropathology.
    4. Selective MOPr-mediated increase in RTP4 expression.
      Title: Regulation of an Opioid Receptor Chaperone Protein, RTP4, by Morphine.
    5. RTP4, a Golgi chaperone, is a regulator of the levels of heterodimers at the cell surface; association with RTP4 protects mu-delta receptors from ubiquitination and degradation
      Title: Cell surface targeting of mu-delta opioid receptor heterodimers by RTP4.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables olfactory receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in defense response to virus ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in detection of chemical stimulus involved in sensory perception of bitter taste IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in detection of chemical stimulus involved in sensory perception of bitter taste ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein insertion into membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein targeting to membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein targeting to membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    receptor-transporting protein 4
    Names
    28 kDa interferon-responsive protein
    28kD interferon alpha responsive protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_023386.6 → NP_075875.3  receptor-transporting protein 4

      See identical proteins and their annotated locations for NP_075875.3

      Status: VALIDATED

      Source sequence(s)
      AC217053
      Consensus CDS
      CCDS28079.1
      UniProtKB/Swiss-Prot
      Q9D3D6, Q9ER80
      UniProtKB/TrEMBL
      Q8R3Q4
      Related
      ENSMUSP00000041091.6, ENSMUST00000038423.6
      Conserved Domains (1) summary
      pfam13695
      Location:51 → 162
      zf-3CxxC; Zinc-binding domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000082.7 Reference GRCm39 C57BL/6J

      Range
      23338976..23432972
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036160102.1 → XP_036015995.1  receptor-transporting protein 4 isoform X1

      UniProtKB/Swiss-Prot
      Q9D3D6, Q9ER80
      UniProtKB/TrEMBL
      Q8R3Q4
      Conserved Domains (1) summary
      pfam13695
      Location:51 → 162
      zf-3CxxC; Zinc-binding domain

    2. XM_030249256.2 → XP_030105116.1  receptor-transporting protein 4 isoform X1

      UniProtKB/Swiss-Prot
      Q9D3D6, Q9ER80
      UniProtKB/TrEMBL
      Q8R3Q4
      Related
      ENSMUSP00000147521.2, ENSMUST00000209422.2
      Conserved Domains (1) summary
      pfam13695
      Location:51 → 162
      zf-3CxxC; Zinc-binding domain

    3. XM_006522491.5 → XP_006522554.1  receptor-transporting protein 4 isoform X1

      See identical proteins and their annotated locations for XP_006522554.1

      UniProtKB/Swiss-Prot
      Q9D3D6, Q9ER80
      UniProtKB/TrEMBL
      Q8R3Q4
      Conserved Domains (1) summary
      pfam13695
      Location:51 → 162
      zf-3CxxC; Zinc-binding domain

    4. XM_030249257.2 → XP_030105117.1  receptor-transporting protein 4 isoform X1

      UniProtKB/Swiss-Prot
      Q9D3D6, Q9ER80
      UniProtKB/TrEMBL
      Q8R3Q4
      Related
      ENSMUSP00000147442.2, ENSMUST00000210901.2
      Conserved Domains (1) summary
      pfam13695
      Location:51 → 162
      zf-3CxxC; Zinc-binding domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9ER80.1 GenPept UniProtKB/Swiss-Prot:Q9ER80

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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