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    Atp1b4 ATPase Na+/K+ transporting, beta 4 polypeptide [ Mus musculus (house mouse) ]

    Gene ID: 67821, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Atp1b4provided by MGI
    Official Full Name
    ATPase Na+/K+ transporting, beta 4 polypeptideprovided by MGI
    Primary source
    MGI:MGI:1915071
    See related
    Ensembl:ENSMUSG00000016327 AllianceGenome:MGI:1915071
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    1110020B02Rik
    Summary
    Predicted to be involved in regulation of transcription, DNA-templated. Located in nucleus. Is expressed in alimentary system; axial skeleton; musculature; and tongue. Orthologous to human ATP1B4 (ATPase Na+/K+ transporting family member beta 4). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in limb E14.5 (RPKM 1.7), CNS E18 (RPKM 0.6) and 2 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Atp1b4 in Genome Data Viewer
    Location:
    X A3.3; X 22.58 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) X NC_000086.8 (37404999..37425661)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (38316122..38336784)

    Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene arylsulfatase K pseudogene Neighboring gene reproductive homeobox 7, pseudogene 1 Neighboring gene STARR-seq mESC enhancer starr_47016 Neighboring gene predicted pseudogene 40 Neighboring gene ATP synthase, H+ transporting, mitochondrial F0 complex, subunit g pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. During evolution, ATP1B4 lost its ancestral function, accumulated in nuclear membrane of perinatal myocytes, and associates with transcriptional coregulator Ski-interacting protein (SKIP).
      Title: Evolution of Na,K-ATPase beta m-subunit into a coregulator of transcription in placental mammals.
    2. primary structure was determined and developmental regulation of the gene (ATP1B4) was analyzed
      Title: Accumulation of beta (m), a structural member of X,K-ATPase beta-subunit family, in nuclear envelopes of perinatal myocytes.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (1) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in potassium ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of DNA-templated transcription IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in sodium ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of chromatin ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nuclear envelope ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nuclear inner membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nuclear inner membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of sodium:potassium-exchanging ATPase complex IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    protein ATP1B4
    Names
    ATPase, (Na+)/K+ transporting, beta 4 polypeptide
    x,K-ATPase subunit beta-m
    x/potassium-transporting ATPase subunit beta-m

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001290389.1 → NP_001277318.1  protein ATP1B4 isoform 2

      See identical proteins and their annotated locations for NP_001277318.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice site, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
      Source sequence(s)
      AK003843, AK053500, AV247095, BY771893
      Consensus CDS
      CCDS72368.1
      UniProtKB/TrEMBL
      B1APX1
      Related
      ENSMUSP00000110787.2, ENSMUST00000115134.2
      Conserved Domains (1) summary
      pfam00287
      Location:84 → 345
      Na_K-ATPase; Sodium / potassium ATPase beta chain

    2. NM_133690.3 → NP_598451.1  protein ATP1B4 isoform 1

      See identical proteins and their annotated locations for NP_598451.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AK003843, AK053500, AV247095, BY771893
      Consensus CDS
      CCDS30090.1
      UniProtKB/Swiss-Prot
      Q543D0, Q99ME5, Q99ME6
      Related
      ENSMUSP00000016471.3, ENSMUST00000016471.9
      Conserved Domains (1) summary
      pfam00287
      Location:84 → 349
      Na_K-ATPase; Sodium / potassium ATPase beta chain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000086.8 Reference GRCm39 C57BL/6J

      Range
      37404999..37425661
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006541533.1 → XP_006541596.1  protein ATP1B4 isoform X1

      Conserved Domains (1) summary
      pfam00287
      Location:2 → 217
      Na_K-ATPase; Sodium / potassium ATPase beta chain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q99ME6.1 GenPept UniProtKB/Swiss-Prot:Q99ME6

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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