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    Rpn2 ribophorin II [ Mus musculus (house mouse) ]

    Gene ID: 20014, updated on 21-Apr-2024

    Summary

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    Official Symbol
    Rpn2provided by MGI
    Official Full Name
    ribophorin IIprovided by MGI
    Primary source
    MGI:MGI:98085
    See related
    Ensembl:ENSMUSG00000027642 AllianceGenome:MGI:98085
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Rpn-2; 1300012C06Rik
    Summary
    Predicted to enable ribosome binding activity. Acts upstream of or within protein N-linked glycosylation. Predicted to be located in autophagosome membrane; nuclear body; and rough endoplasmic reticulum. Predicted to be part of oligosaccharyltransferase complex. Is expressed in several structures, including alimentary system; brain; ear; heart; and integumental system. Orthologous to human RPN2 (ribophorin II). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in placenta adult (RPKM 112.6), genital fat pad adult (RPKM 107.4) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    2 H1; 2 78.2 cM
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (157121018..157168238)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (157279098..157326318)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene RB transcriptional corepressor like 1 Neighboring gene Small nuclear ribonucleoprotein Sm D1 (snRNP core protein D1) (Sm-D1) (Sm-D autoantigen) Neighboring gene STARR-positive B cell enhancer ABC_E4514 Neighboring gene STARR-positive B cell enhancer ABC_E7877 Neighboring gene predicted gene, 57690 Neighboring gene maestro heat-like repeat family member 8 Neighboring gene STARR-seq mESC enhancer starr_06199 Neighboring gene STARR-seq mESC enhancer starr_06200 Neighboring gene STARR-seq mESC enhancer starr_06201 Neighboring gene STARR-positive B cell enhancer ABC_E818 Neighboring gene predicted gene, 54126 Neighboring gene growth hormone releasing hormone Neighboring gene predicted gene, 39974

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. S-glutathionylation of the Rpn2 regulatory subunit inhibits 26 S proteasomal function. Zmijewski JW, et al. J Biol Chem, 2009 Aug 14. PMID 19549781, Free PMC Article
    2. Mapping of the ribophorin II (RPN II) gene to human chromosome 20q12-q13.1 by in-situ hybridization. Löffler C, et al. Hum Genet, 1991 Jun. PMID 2066112
    3. RPN2 gene confers docetaxel resistance in breast cancer. Honma K, et al. Nat Med, 2008 Sep. PMID 18724378
    4. Rat ribophorin II: molecular cloning and chromosomal localization of a highly conserved transmembrane glycoprotein of the rough endoplasmic reticulum. Pirozzi G, et al. Biochem Biophys Res Commun, 1991 May 15. PMID 1710116
    5. NACHO Engages N-Glycosylation ER Chaperone Pathways for α7 Nicotinic Receptor Assembly. Kweon HJ, et al. Cell Rep, 2020 Aug 11. PMID 32783947

    See all (36) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. S-glutathionylation of Rpn2 is a contributory mechanism for H2O2-induced inhibition of 26 S proteasomal function
      Title: S-glutathionylation of the Rpn2 regulatory subunit inhibits 26 S proteasomal function.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (1) 
    • Endonuclease-mediated (2) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables ribosome binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in protein N-linked glycosylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within protein N-linked glycosylation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein N-linked glycosylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in autophagosome membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endoplasmic reticulum membrane NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nuclear body ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of oligosaccharyltransferase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of oligosaccharyltransferase complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2
    Names
    RPN-II
    dolichyl-diphosphooligosaccharide--protein glycosyltransferase 63 kDa subunit
    ribophorin-2
    NP_001342092.1
    NP_001342093.1
    NP_001342094.1
    NP_062616.2
    XP_006499084.1
    XP_006499087.1
    XP_030104723.1
    XP_036015669.1
    XP_036015671.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001355163.1 → NP_001342092.1  dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2 isoform 1 precursor

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AL669828
      UniProtKB/TrEMBL
      A2ACG7
      Related
      ENSMUSP00000029171.6, ENSMUST00000029171.6
      Conserved Domains (1) summary
      pfam05817
      Location:9 → 623
      Ribophorin_II; Oligosaccharyltransferase subunit Ribophorin II

    2. NM_001355164.1 → NP_001342093.1  dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2 isoform 3 precursor

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (3) has a shorter and distinct N-terminus compared to isoform 1.
      Source sequence(s)
      AL669828
      UniProtKB/TrEMBL
      A2ACG7
      Conserved Domains (1) summary
      pfam05817
      Location:6 → 620
      Ribophorin_II; Oligosaccharyltransferase subunit Ribophorin II

    3. NM_001355165.1 → NP_001342094.1  dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2 isoform 4

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR and coding sequence and lacks an alternate in-frame 3' exon compared to variant 1.The resulting isoform (4) is shorter at the N-terminus and lacks an alternate internal segment comared to isoform 1.
      Source sequence(s)
      AL669828
      Related
      ENSMUST00000127252.8
      Conserved Domains (1) summary
      pfam05817
      Location:2 → 405
      Ribophorin_II; Oligosaccharyltransferase subunit Ribophorin II

    4. NM_019642.4 → NP_062616.2  dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2 isoform 2 precursor

      See identical proteins and their annotated locations for NP_062616.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame 3' exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.
      Source sequence(s)
      AK004968
      Consensus CDS
      CCDS16975.1
      UniProtKB/Swiss-Prot
      A2ACG6, Q3TKY0, Q91XH0, Q9DBG6
      UniProtKB/TrEMBL
      Q61833
      Related
      ENSMUSP00000112081.3, ENSMUST00000116380.9
      Conserved Domains (1) summary
      pfam05817
      Location:9 → 623
      Ribophorin_II; Oligosaccharyltransferase subunit Ribophorin II

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      157121018..157168238
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030248863.2 → XP_030104723.1  dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2 isoform X2

      UniProtKB/TrEMBL
      A2ACG7
      Conserved Domains (1) summary
      pfam05817
      Location:26 → 640
      Ribophorin_II; Oligosaccharyltransferase subunit Ribophorin II

    2. XM_006499024.4 → XP_006499087.1  dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2 isoform X1

      UniProtKB/TrEMBL
      A2ACG7
      Conserved Domains (1) summary
      pfam05817
      Location:31 → 645
      Ribophorin_II; Oligosaccharyltransferase subunit Ribophorin II

    3. XM_006499021.5 → XP_006499084.1  dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2 isoform X3

      UniProtKB/TrEMBL
      Q61833
      Conserved Domains (1) summary
      pfam05817
      Location:31 → 645
      Ribophorin_II; Oligosaccharyltransferase subunit Ribophorin II

    4. XM_036159776.1 → XP_036015669.1  dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2 isoform X4

      UniProtKB/TrEMBL
      Q3U505
      Conserved Domains (1) summary
      pfam05817
      Location:26 → 640
      Ribophorin_II; Oligosaccharyltransferase subunit Ribophorin II

    5. XM_036159778.1 → XP_036015671.1  dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2 isoform X5

      UniProtKB/TrEMBL
      Q61833
      Conserved Domains (1) summary
      pfam05817
      Location:6 → 620
      Ribophorin_II; Oligosaccharyltransferase subunit Ribophorin II
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9DBG6.1 GenPept UniProtKB/Swiss-Prot:Q9DBG6

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