Cd33 CD33 molecule [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Cd33provided by MGI
Official Full Name: CD33 moleculeprovided by MGI
Primary source: MGI:MGI:99440
See related: Ensembl:ENSMUSG00000004609 AllianceGenome:MGI:99440
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: gp67; Siglec-3
Summary: Predicted to enable protein phosphatase binding activity and sialic acid binding activity. Predicted to be involved in several processes, including negative regulation of cytokine production; negative regulation of monocyte activation; and positive regulation of protein tyrosine phosphatase activity. Predicted to be located in several cellular components, including Golgi apparatus; external side of plasma membrane; and peroxisome. Predicted to be active in plasma membrane. Is expressed in central nervous system; genitourinary system; spleen; and submandibular gland. Orthologous to human CD33 (CD33 molecule). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in liver E18 (RPKM 4.3), mammary gland adult (RPKM 4.2) and 27 other tissues See more
Orthologs: human all
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Genomic context

Location:: 7 B3; 7 28.25 cM

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	7	NC_000073.7 (43176823..43186679, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	7	NC_000073.6 (43527399..43537424, complement)

Chromosome 7 - NC_000073.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

CD33/TREM2 Signaling Mediates Sleep Deprivation-Induced Memory Impairment by Regulating Microglial Phagocytosis.
Title: CD33/TREM2 Signaling Mediates Sleep Deprivation-Induced Memory Impairment by Regulating Microglial Phagocytosis.
Gene therapy for Alzheimer's disease targeting CD33 reduces amyloid beta accumulation and neuroinflammation.
Title: Gene therapy for Alzheimer's disease targeting CD33 reduces amyloid beta accumulation and neuroinflammation.
knockout of CD33 attenuated amyloid beta (Abeta) pathologyand improved cognition in 5xFAD mice, both of which were abrogated by additional TREM2 knockout. Differential gene expression in 5xFAD;CD33(-/-) microglia depended on the presence of TREM2, suggesting TREM2 acts downstream of CD33. Crosstalk between CD33 and TREM2 includes regulation of the IL-1beta/IL-1RN axis and a gene set in the "receptor activity chemokine"...
Title: TREM2 Acts Downstream of CD33 in Modulating Microglial Pathology in Alzheimer's Disease.
CD33 recruitment inhibits IgE-mediated anaphylaxis and desensitizes mast cells to allergen.
Title: CD33 recruitment inhibits IgE-mediated anaphylaxis and desensitizes mast cells to allergen.
Lectin galactoside-binding soluble 3 binding protein (LGALS3BP) is a tumor-associated immunomodulatory ligand for CD33-related Siglecs.
Title: Lectin galactoside-binding soluble 3 binding protein (LGALS3BP) is a tumor-associated immunomodulatory ligand for CD33-related Siglecs.
CD33-related Siglec-E recognizes the intact neuron and has neuroprotective function by preventing phagocytosis.
Title: Microglial CD33-related Siglec-E inhibits neurotoxicity by preventing the phagocytosis-associated oxidative burst.
mCD33 is expressed on myeloid precursors in the bone marrow
Title: CD33/Siglec-3 binding specificity, expression pattern, and consequences of gene deletion in mice.
SOCS3 inhibited the CD33-induced block on cytokine-induced proliferation. SOCS3 and its target protein CD33 are degraded concomitantly concomitantly.
Title: CD33 responses are blocked by SOCS3 through accelerated proteasomal-mediated turnover.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (3) 1 citation
Endonuclease-mediated (7) 1 citation

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables carbohydrate binding	IEA Inferred from Electronic Annotation more info
enables protein phosphatase binding	ISO Inferred from Sequence Orthology more info
enables sialic acid binding	IBA Inferred from Biological aspect of Ancestor more info
enables sialic acid binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in cell adhesion	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in Golgi apparatus	ISO Inferred from Sequence Orthology more info
located_in cell surface	ISO Inferred from Sequence Orthology more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in external side of plasma membrane	ISO Inferred from Sequence Orthology more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in peroxisome	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: myeloid cell surface antigen CD33

Names: CD33 antigen; sialic acid-binding Ig-like lectin 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001111058.1 → NP_001104528.1 myeloid cell surface antigen CD33 isoform 1 precursor

See identical proteins and their annotated locations for NP_001104528.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript and encodes the longer protein (isoform 1).

Source sequence(s)

AC154108

Consensus CDS

CCDS52224.1

UniProtKB/Swiss-Prot

A2RT59, Q63994, Q63997

Related

ENSMUSP00000004728.6, ENSMUST00000004728.12

Conserved Domains (2) summary

cd00096
Location:21 → 25

Ig; Ig strand A [structural motif]

cl11960
Location:21 → 139

Ig; Immunoglobulin domain
NM_021293.3 → NP_067268.1 myeloid cell surface antigen CD33 isoform 2 precursor

See identical proteins and their annotated locations for NP_067268.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) lacks an exon in the 3' coding region that results in a frameshift compared to variant 1. The resulting protein (isoform 2) is shorter and has a distinct C-terminus compared to isoform 1.

Source sequence(s)

AK155745, BC132379

Consensus CDS

CCDS21173.1

UniProtKB/Swiss-Prot

Q63994

Related

ENSMUSP00000146225.2, ENSMUST00000205503.2

Conserved Domains (2) summary

smart00410
Location:26 → 119

IG_like; Immunoglobulin like

cl11960
Location:21 → 139

Ig; Immunoglobulin domain