Chit1 chitinase 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Chit1provided by MGI
Official Full Name: chitinase 1provided by MGI
Primary source: MGI:MGI:1919134
See related: Ensembl:ENSMUSG00000026450 AllianceGenome:MGI:1919134
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 2300002L19Rik
Summary: Predicted to enable chitin binding activity and endochitinase activity. Predicted to be involved in chitin catabolic process. Predicted to act upstream of or within polysaccharide catabolic process. Predicted to be located in extracellular space. Predicted to be active in extracellular region. Orthologous to human CHIT1 (chitinase 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in stomach adult (RPKM 20.5), testis adult (RPKM 3.6) and 1 other tissue See more
Orthologs: human all
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Genomic context

Location:: 1 E4; 1 58.12 cM

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	1	NC_000067.7 (134038980..134079279)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	1	NC_000067.6 (134111242..134151541)

Chromosome 1 - NC_000067.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Comparative functional analysis between human and mouse chitotriosidase: Substitution at amino acid 218 modulates the chitinolytic and transglycosylation activity.
Title: Comparative functional analysis between human and mouse chitotriosidase: Substitution at amino acid 218 modulates the chitinolytic and transglycosylation activity.
these data show a detrimental role of chit1 in Klebsiella pneumoniae lung infections
Title: Regulation and Role of Chitotriosidase during Lung Infection with Klebsiella pneumoniae.
No significant differences were observed between experimental autoimmune encephalitis and control groups for CHIT-1 expression.
Title: Breast regression protein-39 is not required for experimental autoimmune encephalomyelitis induction.
CHIT1 exerts protective effects against atherosclerosis by suppressing inflammatory responses and polarizing macrophages toward an M2 phenotype, and promoting lipid uptake and cholesterol efflux in macrophages.
Title: Chitinase inhibition promotes atherosclerosis in hyperlipidemic mice.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Gene trapped (1)
Targeted (2) 1 citation

General gene information

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Markers

Chit1 (e-PCR), detects polymorphism
- UniSTS:546695

NoName (e-PCR)
- UniSTS:487585

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables chitin binding	IBA Inferred from Biological aspect of Ancestor more info
enables chitinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables chitinase activity	ISO Inferred from Sequence Orthology more info
enables endochitinase activity	ISO Inferred from Sequence Orthology more info
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables hydrolase activity, acting on glycosyl bonds	IEA Inferred from Electronic Annotation more info
enables hydrolase activity, hydrolyzing O-glycosyl compounds	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within carbohydrate metabolic process	IEA Inferred from Electronic Annotation more info
involved_in carbohydrate metabolic process	IEA Inferred from Electronic Annotation more info
involved_in chitin catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in chitin catabolic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within metabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within polysaccharide catabolic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in extracellular region	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	ISO Inferred from Sequence Orthology more info
located_in lysosome	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: chitotriosidase-1

Names: chitinase 1 (chitotriosidase)

NP_001271453.1

EC 3.2.1.14

NP_001271454.1

EC 3.2.1.14

NP_082255.1

EC 3.2.1.14

XP_006529942.1

EC 3.2.1.14

XP_006529943.1

EC 3.2.1.14

XP_006529944.1

EC 3.2.1.14

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001284524.1 → NP_001271453.1 chitotriosidase-1 isoform 2 precursor

See identical proteins and their annotated locations for NP_001271453.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' UTR and lacks an alternate exon in the 3' coding region which causes a frameshift, compared to variant 1. The resulting protein (isoform 2) is shorter and has a distinct C-terminus compared to isoform 1.

Source sequence(s)

AK009012, AV087814

Consensus CDS

CCDS69943.1

UniProtKB/Swiss-Prot

Q9D7Q1

Related

ENSMUSP00000124331.2, ENSMUST00000160060.8

Conserved Domains (1) summary

cd02872
Location:24 → 345

GH18_chitolectin_chitotriosidase; This conserved domain family includes a large number of catalytically inactive chitinase-like lectins (chitolectins) including YKL-39, YKL-40 (HCGP39), YM1, oviductin, and AMCase (acidic mammalian chitinase), as well as catalytically active ...
NM_001284525.1 → NP_001271454.1 chitotriosidase-1 isoform 1 precursor

See identical proteins and their annotated locations for NP_001271454.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longest transcript and encodes the longer protein (isoform 1). Variants 1 and 3 encode the same protein.

Source sequence(s)

AK009012, AY536287, BC138765

Consensus CDS

CCDS15304.1

UniProtKB/Swiss-Prot

Q6QJD2, Q9D7Q1

UniProtKB/TrEMBL

B2RS82

Conserved Domains (2) summary

cd02872
Location:24 → 383

GH18_chitolectin_chitotriosidase; This conserved domain family includes a large number of catalytically inactive chitinase-like lectins (chitolectins) including YKL-39, YKL-40 (HCGP39), YM1, oviductin, and AMCase (acidic mammalian chitinase), as well as catalytically active ...

pfam01607
Location:418 → 464

CBM_14; Chitin binding Peritrophin-A domain
NM_027979.2 → NP_082255.1 chitotriosidase-1 isoform 1 precursor

See identical proteins and their annotated locations for NP_082255.1

Status: VALIDATED

Description

Transcript Variant: This variant (3) uses an alternate splice site in the 5' UTR, compared to variant 1. Variants 1 and 3 encode the same protein (isoform 1).

Source sequence(s)

AK009012, AY458654, AY536287

Consensus CDS

CCDS15304.1

UniProtKB/Swiss-Prot

Q6QJD2, Q9D7Q1

UniProtKB/TrEMBL

B2RS82

Related

ENSMUSP00000123979.2, ENSMUST00000159963.8

Conserved Domains (2) summary

cd02872
Location:24 → 383

GH18_chitolectin_chitotriosidase; This conserved domain family includes a large number of catalytically inactive chitinase-like lectins (chitolectins) including YKL-39, YKL-40 (HCGP39), YM1, oviductin, and AMCase (acidic mammalian chitinase), as well as catalytically active ...

pfam01607
Location:418 → 464

CBM_14; Chitin binding Peritrophin-A domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000067.7 Reference GRCm39 C57BL/6J

Range

134038980..134079279

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006529879.3 → XP_006529942.1 chitotriosidase-1 isoform X1

See identical proteins and their annotated locations for XP_006529942.1

UniProtKB/Swiss-Prot

Q6QJD2, Q9D7Q1

UniProtKB/TrEMBL

B2RS82

Conserved Domains (2) summary

cd02872
Location:24 → 383

GH18_chitolectin_chitotriosidase; This conserved domain family includes a large number of catalytically inactive chitinase-like lectins (chitolectins) including YKL-39, YKL-40 (HCGP39), YM1, oviductin, and AMCase (acidic mammalian chitinase), as well as catalytically active ...

pfam01607
Location:418 → 464

CBM_14; Chitin binding Peritrophin-A domain
XM_006529880.2 → XP_006529943.1 chitotriosidase-1 isoform X1

See identical proteins and their annotated locations for XP_006529943.1

UniProtKB/Swiss-Prot

Q6QJD2, Q9D7Q1

UniProtKB/TrEMBL

B2RS82

Conserved Domains (2) summary

cd02872
Location:24 → 383

GH18_chitolectin_chitotriosidase; This conserved domain family includes a large number of catalytically inactive chitinase-like lectins (chitolectins) including YKL-39, YKL-40 (HCGP39), YM1, oviductin, and AMCase (acidic mammalian chitinase), as well as catalytically active ...

pfam01607
Location:418 → 464

CBM_14; Chitin binding Peritrophin-A domain
XM_006529881.3 → XP_006529944.1 chitotriosidase-1 isoform X2

See identical proteins and their annotated locations for XP_006529944.1

UniProtKB/Swiss-Prot

Q9D7Q1

Conserved Domains (1) summary

cd02872
Location:24 → 345

GH18_chitolectin_chitotriosidase; This conserved domain family includes a large number of catalytically inactive chitinase-like lectins (chitolectins) including YKL-39, YKL-40 (HCGP39), YM1, oviductin, and AMCase (acidic mammalian chitinase), as well as catalytically active ...