Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Hspg2 perlecan (heparan sulfate proteoglycan 2) [ Mus musculus (house mouse) ]

    Gene ID: 15530, updated on 2-Oct-2021

    Summary

    Official Symbol
    Hspg2provided by MGI
    Official Full Name
    perlecan (heparan sulfate proteoglycan 2)provided by MGI
    Primary source
    MGI:MGI:96257
    See related
    Ensembl:ENSMUSG00000028763
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Pcn; Plc; per; HSPG; AI852380
    Expression
    Broad expression in adrenal adult (RPKM 35.2), subcutaneous fat pad adult (RPKM 30.9) and 20 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Hspg2 in Genome Data Viewer
    Location:
    4 D3; 4 69.93 cM
    Exon count:
    99
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (137196062..137297941)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (137468751..137570630)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 4 NC_000070.5 (137024718..137126545)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene chymotrypsin-like elastase family, member 3B Neighboring gene RIKEN cDNA 1700013G24 gene Neighboring gene predicted gene 13010 Neighboring gene microRNA 7018 Neighboring gene low density lipoprotein receptor class A domain containing 2 Neighboring gene ubiquitin specific peptidase 48 Neighboring gene predicted gene, 54263

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables extracellular matrix structural constituent conferring compression resistance RCA
    inferred from Reviewed Computational Analysis
    more info
    PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protease binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein C-terminus binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within angiogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in animal organ morphogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acts_upstream_of_or_within brain development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within cardiac muscle tissue development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within cartilage development involved in endochondral bone morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within chondrocyte differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within embryonic skeletal system morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within endochondral ossification IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within extracellular matrix organization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of amyloid fibril formation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of cell death ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within protein localization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in receptor-mediated endocytosis IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in receptor-mediated endocytosis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in tissue development IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in Golgi lumen TAS
    Traceable Author Statement
    more info
     
    is_active_in basement membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in basement membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in collagen-containing extracellular matrix HDA PubMed 
    located_in extracellular matrix IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
     
    located_in extracellular region TAS
    Traceable Author Statement
    more info
     

    General protein information

    Preferred Names
    basement membrane-specific heparan sulfate proteoglycan core protein

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_008305.3NP_032331.2  basement membrane-specific heparan sulfate proteoglycan core protein precursor

      Status: VALIDATED

      Source sequence(s)
      AK147294, BC094353, BX323857, CA326802, CB525885, CD349187, CN694897, CN696673, DQ266428, M77174, M83997
      Consensus CDS
      CCDS51333.1
      UniProtKB/Swiss-Prot
      Q05793
      UniProtKB/TrEMBL
      E9PZ16, Q2XQV0, Q3UHH3, Q52KG8
      Related
      ENSMUSP00000131316.2, ENSMUST00000171332.2
      Conserved Domains (18) summary
      cd05743
      Location:421498
      Ig_Perlecan_D2_like; Immunoglobulin (Ig)-like domain II (D2) of the human basement membrane heparan sulfate proteoglycan perlecan, also known as HSPG2
      cd05754
      Location:17701855
      Ig3_Perlecan_like; Third immunoglobulin (Ig)-like domain found in Perlecan and similar proteins
      smart00408
      Location:26412700
      IGc2; Immunoglobulin C-2 Type
      smart00281
      Location:13931516
      LamB; Laminin B domain
      smart00409
      Location:413490
      IG; Immunoglobulin
      smart00410
      Location:32153291
      IG_like; Immunoglobulin like
      cd00054
      Location:38413874
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
      cd00055
      Location:764806
      EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...
      cd00110
      Location:41964354
      LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
      cd00112
      Location:325359
      LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
      pfam07679
      Location:35723654
      I-set; Immunoglobulin I-set domain
      pfam00008
      Location:41014131
      EGF; EGF-like domain
      pfam00047
      Location:30233103
      ig; Immunoglobulin domain
      pfam00053
      Location:12751322
      Laminin_EGF; Laminin EGF domain
      pfam00057
      Location:283319
      Ldl_recept_a; Low-density lipoprotein receptor domain class A
      pfam13895
      Location:22492325
      Ig_2; Immunoglobulin domain
      cl02507
      Location:80194
      SEA; SEA domain
      cl11960
      Location:35773654
      Ig; Immunoglobulin domain

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      137196062..137297941
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030253229.1XP_030109089.1  basement membrane-specific heparan sulfate proteoglycan core protein isoform X1

      Conserved Domains (18) summary
      cd05743
      Location:438515
      Ig_Perlecan_like; Immunoglobulin (Ig)-like domain of the human basement membrane heparan sulfate proteoglycan perlecan, also known as HSPG2, and similar domains
      cd05754
      Location:17871872
      Ig_Perlecan_like; Igmmunoglobulin (Ig)-like domain found in Perlecan and similar proteins
      smart00408
      Location:26582717
      IGc2; Immunoglobulin C-2 Type
      smart00281
      Location:607733
      LamB; Laminin B domain
      smart00409
      Location:32303306
      IG; Immunoglobulin
      smart00410
      Location:16991779
      IG_like; Immunoglobulin like
      cd00054
      Location:38563889
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
      cd00055
      Location:781823
      EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...
      cd00110
      Location:42114369
      LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
      cd00112
      Location:342376
      LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
      cd00096
      Location:33273390
      Ig; Immunoglobulin domain
      pfam00008
      Location:41164146
      EGF; EGF-like domain
      pfam00052
      Location:14131545
      Laminin_B; Laminin B (Domain IV)
      pfam00053
      Location:12921339
      Laminin_EGF; Laminin EGF domain
      pfam00057
      Location:300336
      Ldl_recept_a; Low-density lipoprotein receptor domain class A
      pfam07679
      Location:35873669
      I-set; Immunoglobulin I-set domain
      cl02507
      Location:80194
      SEA; SEA domain
      cl11960
      Location:24502535
      Ig; Immunoglobulin domain
    2. XM_006538575.2XP_006538638.1  basement membrane-specific heparan sulfate proteoglycan core protein isoform X2

      Related
      ENSMUSP00000030547.9, ENSMUST00000030547.15
      Conserved Domains (18) summary
      cd05743
      Location:421498
      Ig_Perlecan_like; Immunoglobulin (Ig)-like domain of the human basement membrane heparan sulfate proteoglycan perlecan, also known as HSPG2, and similar domains
      cd05754
      Location:17701855
      Ig_Perlecan_like; Igmmunoglobulin (Ig)-like domain found in Perlecan and similar proteins
      smart00408
      Location:26412700
      IGc2; Immunoglobulin C-2 Type
      smart00281
      Location:590716
      LamB; Laminin B domain
      smart00409
      Location:28292905
      IG; Immunoglobulin
      smart00410
      Location:32133289
      IG_like; Immunoglobulin like
      cd00054
      Location:38393872
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
      cd00055
      Location:764806
      EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...
      cd00110
      Location:41944352
      LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
      cd00112
      Location:325359
      LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
      cd00096
      Location:33103373
      Ig; Immunoglobulin domain
      pfam00008
      Location:40994129
      EGF; EGF-like domain
      pfam00052
      Location:13961528
      Laminin_B; Laminin B (Domain IV)
      pfam00053
      Location:12751322
      Laminin_EGF; Laminin EGF domain
      pfam00057
      Location:283319
      Ldl_recept_a; Low-density lipoprotein receptor domain class A
      pfam07679
      Location:35703652
      I-set; Immunoglobulin I-set domain
      cl02507
      Location:80194
      SEA; SEA domain
      cl11960
      Location:24332518
      Ig; Immunoglobulin domain
    3. XM_036163696.1XP_036019589.1  basement membrane-specific heparan sulfate proteoglycan core protein isoform X3

      Conserved Domains (17) summary
      cd05743
      Location:438515
      Ig_Perlecan_like; Immunoglobulin (Ig)-like domain of the human basement membrane heparan sulfate proteoglycan perlecan and similar proteins
      smart00408
      Location:26582717
      IGc2; Immunoglobulin C-2 Type
      smart00281
      Location:607733
      LamB; Laminin B domain
      smart00409
      Location:16991779
      IG; Immunoglobulin
      smart00410
      Location:28462922
      IG_like; Immunoglobulin like
      cd00055
      Location:781823
      EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...
      cd00112
      Location:342376
      LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
      pfam00052
      Location:14131545
      Laminin_B; Laminin B (Domain IV)
      pfam00053
      Location:12921339
      Laminin_EGF; Laminin EGF domain
      pfam00057
      Location:300336
      Ldl_recept_a; Low-density lipoprotein receptor domain class A
      pfam07679
      Location:35873669
      I-set; Immunoglobulin I-set domain
      pfam13927
      Location:32233293
      Ig_3; Immunoglobulin domain
      cd00096
      Location:35893592
      Ig; Ig strand A [structural motif]
      cd05754
      Location:17871872
      IgI_Perlecan_like; Immunoglobulin (Ig)-like domain found in Perlecan and similar proteins; member of the I-set of Ig superfamily (IgSF) domains
      cl02507
      Location:80194
      SEA; SEA domain
      cl11960
      Location:24502535
      Ig; Immunoglobulin domain
      cl22861
      Location:36763721
      LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
    Support Center