Pofut2 protein O-fucosyltransferase 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Pofut2provided by MGI
Official Full Name: protein O-fucosyltransferase 2provided by MGI
Primary source: MGI:MGI:1916863
See related: Ensembl:ENSMUSG00000020260 AllianceGenome:MGI:1916863
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: FUT13; C21orf80; 2310011G23Rik
Summary: Enables fucosyltransferase activity. Acts upstream of or within several processes, including fucosylation; mesoderm formation; and regulation of epithelial to mesenchymal transition. Predicted to be located in Golgi apparatus. Is expressed in several structures, including alimentary system; central nervous system; extraembryonic component; genitourinary system; and sensory organ. Orthologous to human POFUT2 (protein O-fucosyltransferase 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in ovary adult (RPKM 51.4), limb E14.5 (RPKM 44.3) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 10 C1; 10 39.72 cM

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	10	NC_000076.7 (77095056..77105420)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	10	NC_000076.6 (77259081..77269586)

Chromosome 10 - NC_000076.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pofut2 was required during mouse gastrulation to coordinate morphogenetic movements and specify a range of tissues in the mouse embryo.
Title: O-fucosylation of thrombospondin type 1 repeats restricts epithelial to mesenchymal transition (EMT) and maintains epiblast pluripotency during mouse gastrulation.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Gene trapped (3)
Targeted (3) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH136106 (e-PCR)
- UniSTS:210101

Pofut2 (e-PCR), detects polymorphism
- UniSTS:532683

Pofut2 (e-PCR), detects polymorphism
- UniSTS:532684

2310011G23Rik (e-PCR), detects polymorphism
- UniSTS:259021

2310011G23Rik (e-PCR), detects polymorphism
- UniSTS:259570

RH129685 (e-PCR)
- UniSTS:212982

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables fucosyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables glycosyltransferase activity	IEA Inferred from Electronic Annotation more info
enables peptide-O-fucosyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables peptide-O-fucosyltransferase activity	ISO Inferred from Sequence Orthology more info
enables transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within carbohydrate metabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within fucose metabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within fucosylation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within mesoderm formation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of protein folding	ISO Inferred from Sequence Orthology more info
involved_in protein O-linked fucosylation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of epithelial to mesenchymal transition	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of gene expression	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of secretion	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in Golgi apparatus	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: GDP-fucose protein O-fucosyltransferase 2

Names: O-FucT-2; peptide-O-fucosyltransferase 2

NP_084538.2

EC 2.4.1.221

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.