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    Lmtk2 lemur tyrosine kinase 2 [ Mus musculus (house mouse) ]

    Gene ID: 231876, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Lmtk2provided by MGI
    Official Full Name
    lemur tyrosine kinase 2provided by MGI
    Primary source
    MGI:MGI:3036247
    See related
    Ensembl:ENSMUSG00000038970 AllianceGenome:MGI:3036247
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    BREK; KPI2; cprk; KPI-2; aatyk2; 2900041G10Rik; A330101P12Rik
    Summary
    Predicted to enable myosin VI binding activity; protein phosphatase inhibitor activity; and protein serine/threonine kinase activity. Predicted to be involved in several processes, including early endosome to late endosome transport; protein phosphorylation; and transferrin transport. Predicted to act upstream of or within axon guidance and neurotrophin TRK receptor signaling pathway. Predicted to be located in several cellular components, including endosome; growth cone; and neuronal cell body. Predicted to be integral component of membrane. Predicted to be part of receptor complex. Predicted to be integral component of plasma membrane. Is expressed in brain; olfactory cortex marginal layer; and pancreas. Orthologous to human LMTK2 (lemur tyrosine kinase 2). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in cortex adult (RPKM 17.2), frontal lobe adult (RPKM 15.5) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Lmtk2 in Genome Data Viewer
    Location:
    5 G2; 5 82.85 cM
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (144037179..144125026)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (144100361..144188208)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 54312 Neighboring gene oncomodulin Neighboring gene elongation factor 1-gamma pseudogene Neighboring gene STARR-seq mESC enhancer starr_14800 Neighboring gene STARR-positive B cell enhancer ABC_E1061 Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:144923715-144923898 Neighboring gene basic helix-loop-helix family, member a15 Neighboring gene tectonin beta-propeller repeat containing 1 Neighboring gene STARR-positive B cell enhancer ABC_E2183

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Azoospermia in mice with targeted disruption of the Brek/Lmtk2 (brain-enriched kinase/lemur tyrosine kinase 2) gene. Kawa S, et al. Proc Natl Acad Sci U S A, 2006 Dec 19. PMID 17158803, Free PMC Article
    2. Overexpression of lemur tyrosine kinase-2 protects neurons from oxygen-glucose deprivation/reoxygenation-induced injury through reinforcement of Nrf2 signaling by modulating GSK-3β phosphorylation. Bao H, et al. Biochem Biophys Res Commun, 2020 Jan 22. PMID 31722791
    3. Involvement of BREK, a serine/threonine kinase enriched in brain, in NGF signalling. Kawa S, et al. Genes Cells, 2004 Mar. PMID 15005709
    4. Structural and functional analysis of the apoptosis-associated tyrosine kinase (AATYK) family. Tomomura M, et al. Neuroscience, 2007 Aug 24. PMID 17651901
    5. In silico QTL mapping of basal liver iron levels in inbred mouse strains. McLachlan S, et al. Physiol Genomics, 2011 Feb 11. PMID 21062905, Free PMC Article

    See all (28) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. LMTK2 overexpression alleviated oxygen-glucose deprivation/reoxygenation-induced neuronal apoptosis and oxidative damage by enhancing Nrf2/antioxidant response element antioxidant signaling via modulation of GSK-3beta phosphorylation.
      Title: Overexpression of lemur tyrosine kinase-2 protects neurons from oxygen-glucose deprivation/reoxygenation-induced injury through reinforcement of Nrf2 signaling by modulating GSK-3β phosphorylation.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (1) 
    • Targeted (1)  1 citation
    • Endonuclease-mediated (3) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables myosin VI binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein phosphatase inhibitor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein serine/threonine kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within axon guidance ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    involved_in early endosome to late endosome transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in endocytic recycling ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within nervous system development ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    acts_upstream_of_or_within neurotrophin TRK receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    involved_in peptidyl-serine phosphorylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in peptidyl-threonine phosphorylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within protein autophosphorylation ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    involved_in protein autophosphorylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein phosphorylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in receptor recycling ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in transferrin transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    located_in early endosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in growth cone ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in neuronal cell body ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in perinuclear region of cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in recycling endosome ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    serine/threonine-protein kinase LMTK2
    Names
    apoptosis-associated tyrosine kinase 2
    brain-enriched kinase
    NP_001074578.1
    XP_006504888.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001081109.2 → NP_001074578.1  serine/threonine-protein kinase LMTK2

      See identical proteins and their annotated locations for NP_001074578.1

      Status: VALIDATED

      Source sequence(s)
      AC121845
      Consensus CDS
      CCDS39376.1
      UniProtKB/Swiss-Prot
      A6BLY9, Q3TYD6, Q6PDK6, Q6ZPY9, Q8CA34
      Related
      ENSMUSP00000048238.8, ENSMUST00000041804.8
      Conserved Domains (2) summary
      cd05086
      Location:138 → 408
      PTKc_Aatyk2; Catalytic domain of the Protein Tyrosine Kinase, Apoptosis-associated tyrosine kinase 2
      pfam07714
      Location:136 → 406
      Pkinase_Tyr; Protein tyrosine kinase

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      144037179..144125026
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006504825.5 → XP_006504888.1  serine/threonine-protein kinase LMTK2 isoform X1

      Conserved Domains (1) summary
      cd05086
      Location:137 → 407
      PTKc_Aatyk2; Catalytic domain of the Protein Tyrosine Kinase, Apoptosis-associated tyrosine kinase 2
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q3TYD6.3 GenPept UniProtKB/Swiss-Prot:Q3TYD6

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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