Map6 microtubule-associated protein 6 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Map6provided by MGI
Official Full Name: microtubule-associated protein 6provided by MGI
Primary source: MGI:MGI:1201690
See related: Ensembl:ENSMUSG00000055407 AllianceGenome:MGI:1201690
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: STOP; Map-6; Mtap6; 2810411E12Rik
Summary: Enables microtubule binding activity. Predicted to be involved in several processes, including axonal transport of mitochondrion; generation of neurons; and lysosome localization. Predicted to be located in several cellular components, including Golgi apparatus; perinuclear region of cytoplasm; and secretory vesicle. Predicted to be active in several cellular components, including Golgi-associated vesicle; cis-Golgi network; and microtubule. Is expressed in cranial ganglion; dorsal root ganglion; and sensory organ. Used to study schizophrenia. Orthologous to human MAP6 (microtubule associated protein 6). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in CNS E18 (RPKM 17.6), whole brain E14.5 (RPKM 16.8) and 9 other tissues See more
Orthologs: human all
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Genomic context

Location:: 7 E1; 7 54.05 cM

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	7	NC_000073.7 (98916270..98986344)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	7	NC_000073.6 (99266779..99337137)

Chromosome 7 - NC_000073.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Altered circadian activity and sleep/wake rhythms in the stable tubule only polypeptide (STOP) null mouse model of schizophrenia.
Title: Altered circadian activity and sleep/wake rhythms in the stable tubule only polypeptide (STOP) null mouse model of schizophrenia.
This is the first study to describe MAP6 as a glycoprotein containing Gal-(beta-1,3)-GalNAc oligosaccharides and to show that hyperglycosylation of MAP6 is strongly associated with the pathogenesis of Parkinson's Disease.
Title: Role of microtubule-associated protein 6 glycosylated with Gal-(β-1,3)-GalNAc in Parkinson's disease.
MAP6 deletion results in alterations of microtubule network, sarcoplasmic reticulum organization and calcium release.
Title: Deletion of the microtubule-associated protein 6 (MAP6) results in skeletal muscle dysfunction.
MAP6 is involved in the formation and the maintenance of mature post-synaptic dendritic spines.MAP6 is involved in the stabilisation of actin filaments in dendritic spines.
Title: A key function for microtubule-associated-protein 6 in activity-dependent stabilisation of actin filaments in dendritic spines.
show that MAP6 proteins interact directly with both Tctex1 and the C-terminus of Cav2.2/N-type calcium channels.
Title: MAP6 interacts with Tctex1 and Ca(v) 2.2/N-type calcium channels to regulate calcium signalling in neurons.
MAP6 is present at the Golgi complex and in secretory vesicles in unpolarized cells and re-distributed to newly forming axons, where it binds and stabilizes axonal microtubules. A palmitoylation cycle controls MAP6 membrane-microtubule shuttling and is required for its polarized distribution in axons.
Title: Dynamic Palmitoylation Targets MAP6 to the Axon to Promote Microtubule Stabilization during Neuronal Polarization.
Mice deficient in stable tubule only polypeptide (STOP) show sleep/wake patterns that resemble those seen in patients with schizophrenia.
Title: Disruptions of Sleep/Wake Patterns in the Stable Tubule Only Polypeptide (STOP) Null Mouse Model of Schizophrenia.
MAP6 deletion disrupts brain connectivity and is associated with a lack of post-commissural fornix fibres. MAP6 contributes to fornix development by regulating axonal elongation induced by Semaphorin 3E.
Title: Microtubule-associated protein 6 mediates neuronal connectivity through Semaphorin 3E-dependent signalling for axonal growth.
STOP/Map6 knockout mice are a valid model for cognitive deficits in schizophrenia.
Title: Reduced expression of STOP/MAP6 in mice leads to cognitive deficits.
MAP6 might serve as a temperature sensor adapting its conformation according to the temperature to maintain the cellular microtubule network in organisms exposed to temperature decrease.
Title: MAP6-F is a temperature sensor that directly binds to and protects microtubules from cold-induced depolymerization.

Submit: New GeneRIF Correction See all GeneRIFs (30)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (1) 1 citation
Endonuclease-mediated (3)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D7Mit149 (e-PCR), detects polymorphism
- UniSTS:131046

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables calmodulin binding	IEA Inferred from Electronic Annotation more info
enables microtubule binding	IBA Inferred from Biological aspect of Ancestor more info
enables microtubule binding	IDA Inferred from Direct Assay more info	PubMed
enables microtubule binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in axonal transport of mitochondrion	ISO Inferred from Sequence Orthology more info
involved_in cytoskeleton-dependent intracellular transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in dendrite morphogenesis	IBA Inferred from Biological aspect of Ancestor more info
involved_in dendrite morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in lysosome localization	ISO Inferred from Sequence Orthology more info
involved_in microtubule cytoskeleton organization	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of axonogenesis	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of axonogenesis	ISO Inferred from Sequence Orthology more info
involved_in regulation of microtubule cytoskeleton organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of microtubule cytoskeleton organization	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in Golgi apparatus	ISO Inferred from Sequence Orthology more info
is_active_in Golgi-associated vesicle	IBA Inferred from Biological aspect of Ancestor more info
is_active_in axon	IBA Inferred from Biological aspect of Ancestor more info
located_in axon	ISO Inferred from Sequence Orthology more info
located_in cell projection	IEA Inferred from Electronic Annotation more info
is_active_in cis-Golgi network	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoplasmic vesicle	IEA Inferred from Electronic Annotation more info
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info
is_active_in dendrite	IBA Inferred from Biological aspect of Ancestor more info
located_in dendrite	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in microtubule	IBA Inferred from Biological aspect of Ancestor more info
located_in microtubule	ISO Inferred from Sequence Orthology more info
located_in neuron projection	ISO Inferred from Sequence Orthology more info
located_in perinuclear region of cytoplasm	ISO Inferred from Sequence Orthology more info
located_in secretory vesicle	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: microtubule-associated protein 6

Names: stable tubule-only polypeptide

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001043355.2 → NP_001036820.2 microtubule-associated protein 6 isoform 3

Status: VALIDATED

Description

Transcript Variant: This variant (3) differs in the 5' coding region, uses a downstream, in-frame start codon as described in PubMed: 14567673, and lacks an alternate exon in the 3' coding region that results in a frameshift, compared to variant 1. These differences result in a shorter protein (isoform 3, also known as F-STOP) with shorter and distinct N- and C-termini, compared to isoform 1.

Source sequence(s)

AC111120, AC158748

Consensus CDS

CCDS40029.1

UniProtKB/Swiss-Prot

Q7TSJ2

Related

ENSMUSP00000102717.3, ENSMUST00000107100.3

Conserved Domains (1) summary

pfam05217
Location:224 → 281

STOP; STOP protein
NM_001048167.1 → NP_001041632.1 microtubule-associated protein 6 isoform 2

See identical proteins and their annotated locations for NP_001041632.1

Status: VALIDATED

Description

Transcript Variant: This variant(2) lacks an alternate in-frame exon in the 3' coding region and differs in the 3' UTR, compared to variant 1. This results in a shorter protein (isoform 2, also known as E-STOP) with a distinct C-terminus, compared to isoform 1.

Source sequence(s)

AC111120, AC158748

Consensus CDS

CCDS85345.1

UniProtKB/TrEMBL

D3Z6W1

Related

ENSMUSP00000146340.2, ENSMUST00000127492.2

Conserved Domains (1) summary

pfam05217
Location:427 → 521

STOP; STOP protein
NM_010837.3 → NP_034967.2 microtubule-associated protein 6 isoform 1

See identical proteins and their annotated locations for NP_034967.2

Status: VALIDATED

Description

Transcript Variant: This variant (1) encodes the longest protein (isoform 1), also known as N-STOP.

Source sequence(s)

AK018193, AK087413, BE951502, BE980868, BQ444318

Consensus CDS

CCDS21479.1

UniProtKB/Swiss-Prot

O55129, O70586, O70587, Q78DV4, Q78DV5, Q7TSJ2

Related

ENSMUSP00000146585.2, ENSMUST00000207883.2

Conserved Domains (1) summary

pfam05217
Location:117 → 185

STOP; STOP protein