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    Tbpl2 TATA box binding protein like 2 [ Mus musculus (house mouse) ]

    Gene ID: 227606, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Tbpl2provided by MGI
    Official Full Name
    TATA box binding protein like 2provided by MGI
    Primary source
    MGI:MGI:2684058
    See related
    Ensembl:ENSMUSG00000061809 AllianceGenome:MGI:2684058
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Trf3; Gm348
    Summary
    Enables DNA binding activity. Predicted to be involved in DNA-templated transcription, initiation. Located in cytoplasm and nucleus. Is expressed in early conceptus and gonad. Orthologous to human TBPL2 (TATA-box binding protein like 2). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Low expression observed in reference dataset See more
    Orthologs
    human all
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    Genomic context

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    Location:
    2 A3; 2 16.14 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (23961378..23986607, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (24071366..24096595, complement)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene SH3 domain protein 2C, pseudogene 1 Neighboring gene STARR-seq mESC enhancer starr_03933 Neighboring gene STARR-seq mESC enhancer starr_03934 Neighboring gene STARR-seq mESC enhancer starr_03935 Neighboring gene STARR-seq mESC enhancer starr_03936 Neighboring gene STARR-seq mESC enhancer starr_03937 Neighboring gene STARR-seq mESC enhancer starr_03939 Neighboring gene STARR-seq mESC enhancer starr_03940 Neighboring gene STARR-seq mESC enhancer starr_03942 Neighboring gene histamine N-methyltransferase Neighboring gene STARR-seq mESC enhancer starr_03943 Neighboring gene STARR-seq mESC enhancer starr_03944 Neighboring gene STARR-seq mESC enhancer starr_03945 Neighboring gene STARR-seq mESC enhancer starr_03946 Neighboring gene interleukin 36B Neighboring gene DEAD (Asp-Glu-Ala-Asp) box polypeptide 6 pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. TBP2 is essential for germ cell development by regulating transcription and chromatin condensation in the oocyte. Gazdag E, et al. Genes Dev, 2009 Sep 15. PMID 19759265, Free PMC Article
    2. Regulated expression of TATA-binding protein-related factor 3 (TRF3) during early embryogenesis. Yang Y, et al. Cell Res, 2006 Jul. PMID 16721357
    3. TBPL2/TFIIA complex establishes the maternal transcriptome through oocyte-specific promoter usage. Yu C, et al. Nat Commun, 2020 Dec 22. PMID 33353944, Free PMC Article
    4. TBP/TFIID-dependent activation of MyoD target genes in skeletal muscle cells. Malecova B, et al. Elife, 2016 Feb 25. PMID 26880551, Free PMC Article
    5. Transcriptional repression of the mouse wee1 gene by TBP-related factor 2. Tanaka Y, et al. Biochem Biophys Res Commun, 2007 Jan 5. PMID 17109819

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. TBPL2/TFIIA complex establishes the maternal transcriptome through oocyte-specific promoter usage.
      Title: TBPL2/TFIIA complex establishes the maternal transcriptome through oocyte-specific promoter usage.
    2. TBP2 binds to promoters of misregulated genes, suggesting that TBP2 directly regulates their expression
      Title: TBP2 is essential for germ cell development by regulating transcription and chromatin condensation in the oocyte.
    3. properties of a TAF3/TRF3 complex in directing transcription initiation at the Myogenin promoter
      Title: MyoD targets TAF3/TRF3 to activate myogenin transcription.
    4. TRF3 is a nuclear protein that is present in all human and mouse tissues and cell lines examined
      Title: TRF3, a TATA-box-binding protein-related factor, is vertebrate-specific and widely expressed.
    5. Data suggest that TRF3 plays a role in early mouse development, and may also be involved in Pol I transcription.
      Title: Regulated expression of TATA-binding protein-related factor 3 (TRF3) during early embryogenesis.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    General gene information

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    Markers

    Homology

    Clone Names

    • RP23-263E15.2

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables RNA polymerase II general transcription initiation factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in DNA-templated transcription initiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within multicellular organism development IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in female germ cell nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    TATA box-binding protein-like 2
    Names
    TATA box-binding protein-like protein 2
    TATA box-binding protein-related factor 3
    TBP-like 2
    TBP-like protein 2
    TBP-related factor 3 (Trf3)

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001289689.1 → NP_001276618.1  TATA box-binding protein-like 2 isoform 2

      See identical proteins and their annotated locations for NP_001276618.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 3' coding region, compared to variant 1. It encodes isoform 2, which is shorter by an amino acid, compared to isoform 1.
      Source sequence(s)
      AL844838
      UniProtKB/TrEMBL
      B7ZMZ6, Z4YMT0
      Related
      ENSMUSP00000120310.2, ENSMUST00000153338.2
      Conserved Domains (2) summary
      PLN00062
      Location:173 → 349
      PLN00062; TATA-box-binding protein; Provisional
      cd04516
      Location:173 → 346
      TBP_eukaryotes; eukaryotic TATA box binding protein (TBP): Present in archaea and eukaryotes, TBPs are transcription factors that recognize promoters and initiate transcription. TBP has been shown to be an essential component of three different transcription initiation ...

    2. NM_199059.2 → NP_951014.1  TATA box-binding protein-like 2 isoform 1

      See identical proteins and their annotated locations for NP_951014.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (1).
      Source sequence(s)
      AL844838
      Consensus CDS
      CCDS15732.1
      UniProtKB/Swiss-Prot
      A2AQK6, Q498A1, Q6SJ95
      UniProtKB/TrEMBL
      Z4YMT0
      Related
      ENSMUSP00000079309.2, ENSMUST00000080453.8
      Conserved Domains (2) summary
      PLN00062
      Location:173 → 350
      PLN00062; TATA-box-binding protein; Provisional
      cd04516
      Location:173 → 347
      TBP_eukaryotes; eukaryotic TATA box binding protein (TBP): Present in archaea and eukaryotes, TBPs are transcription factors that recognize promoters and initiate transcription. TBP has been shown to be an essential component of three different transcription initiation ...

    RNA

    1. NR_110359.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) uses alternate splice sites in two internal exons, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AL844838

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      23961378..23986607 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6SJ95.1 GenPept UniProtKB/Swiss-Prot:Q6SJ95

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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