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    Gpr137b G protein-coupled receptor 137B [ Mus musculus (house mouse) ]

    Gene ID: 83924, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Gpr137bprovided by MGI
    Official Full Name
    G protein-coupled receptor 137Bprovided by MGI
    Primary source
    MGI:MGI:1891463
    See related
    Ensembl:ENSMUSG00000021306 AllianceGenome:MGI:1891463
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Tm7sf1; D13Abb1e; C730041E01
    Summary
    Involved in negative regulation of bone resorption; negative regulation of osteoclast differentiation; and regulation of macrophage activation. Located in lysosomal membrane. Is expressed in several structures, including alimentary system; brain; eye; genitourinary system; and immune system. Orthologous to human GPR137B (G protein-coupled receptor 137B). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in kidney adult (RPKM 66.3), lung adult (RPKM 28.3) and 20 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    13 A1; 13 5.24 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (13528035..13568250, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (13357620..13393644, complement)

    Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_33678 Neighboring gene small nucleolar RNA SNORA73 family Neighboring gene ERO1-like beta pseudogene Neighboring gene STARR-seq mESC enhancer starr_33679 Neighboring gene STARR-positive B cell enhancer ABC_E7205 Neighboring gene embryonic H3 histone Neighboring gene nidogen 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. TM7SF1, an important autophagy regulatory protein in mouse podocytes. Hu Y, et al. Biochem Biophys Res Commun, 2020 Jul 12. PMID 32482387
    2. Gpr137b is an orphan G-protein-coupled receptor associated with M2 macrophage polarization. Islam Z, et al. Biochem Biophys Res Commun, 2019 Feb 12. PMID 30595385
    3. Cloning and characterization of a novel gene (TM7SF1) encoding a putative seven-pass transmembrane protein that is upregulated during kidney development. Spangenberg C, et al. Genomics, 1998 Mar 1. PMID 9521871
    4. Identification and characterization of a mouse homolog for decidual/trophoblast prolactin-related protein. Orwig KE, et al. Endocrinology, 1997 Dec. PMID 9389538
    5. The methionine synthase (Mtr) gene maps to proximal mouse chromosome 13. Zhang ZX, et al. Mamm Genome, 1997 Oct. PMID 9321480

    See all (30) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Long Noncoding RNA Gpr137b-ps Promotes Advanced Atherosclerosis via the Regulation of Autophagy in Macrophages.
      Title: Long Noncoding RNA Gpr137b-ps Promotes Advanced Atherosclerosis via the Regulation of Autophagy in Macrophages.
    2. TM7SF1, an important autophagy regulatory protein in mouse podocytes.
      Title: TM7SF1, an important autophagy regulatory protein in mouse podocytes.
    3. A role for G protein-coupled receptor 137b in bone remodeling in mouse and zebrafish.
      Title: A role for G protein-coupled receptor 137b in bone remodeling in mouse and zebrafish.
    4. Gpr137b is involved in interleukin-4-induced M2 macrophage polarization. Gpr137b is not involved in lipopolysaccharide-induced M1 macrophage polarization.
      Title: Gpr137b is an orphan G-protein-coupled receptor associated with M2 macrophage polarization.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (4) 
    • Endonuclease-mediated (3) 

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of bone resorption IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of bone resorption IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of osteoclast differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of osteoclast differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of TORC1 signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of TORC1 signaling ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of protein localization to lysosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of GTPase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of autophagy IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of autophagy ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of macrophage activation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in lysosomal membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in lysosomal membrane IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    located_in lysosomal membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    integral membrane protein GPR137B
    Names
    transmembrane 7 superfamily member 1 protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_031999.2 → NP_114388.2  integral membrane protein GPR137B

      See identical proteins and their annotated locations for NP_114388.2

      Status: VALIDATED

      Source sequence(s)
      AK080884, BB847916, BU758113
      Consensus CDS
      CCDS26243.1
      UniProtKB/Swiss-Prot
      Q3T9U4, Q8BNQ3, Q99LK4, Q9JHD9
      UniProtKB/TrEMBL
      A0A0R4J022
      Related
      ENSMUSP00000021738.9, ENSMUST00000021738.10
      Conserved Domains (1) summary
      TIGR03022
      Location:65 → 176
      WbaP_sugtrans; Undecaprenyl-phosphate galactose phosphotransferase, WbaP

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000079.7 Reference GRCm39 C57BL/6J

      Range
      13528035..13568250 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006516805.5 → XP_006516868.1  integral membrane protein GPR137B isoform X1

      UniProtKB/TrEMBL
      A0A1Y7VLJ5, Q8C7F6
      Related
      ENSMUSP00000152434.2, ENSMUST00000223093.2
      Conserved Domains (1) summary
      TIGR03022
      Location:65 → 176
      WbaP_sugtrans; Undecaprenyl-phosphate galactose phosphotransferase, WbaP

    RNA

    1. XR_382078.3 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8BNQ3.2 GenPept UniProtKB/Swiss-Prot:Q8BNQ3

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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