Foxp4 forkhead box P4 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Foxp4provided by MGI
Official Full Name: forkhead box P4provided by MGI
Primary source: MGI:MGI:1921373
See related: Ensembl:ENSMUSG00000023991 AllianceGenome:MGI:1921373
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: mFKHLA; 1200010K03Rik; 2310007G05Rik
Summary: Enables DNA-binding transcription repressor activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and identical protein binding activity. Acts upstream of or within several processes, including embryonic foregut morphogenesis; lung secretory cell differentiation; and negative regulation of lung goblet cell differentiation. Predicted to be active in nucleus. Is expressed in several structures, including central nervous system; genitourinary system; gut; hindlimb digit mesenchyme; and skeleton. Orthologous to human FOXP4 (forkhead box P4). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in stomach adult (RPKM 50.9), colon adult (RPKM 45.3) and 27 other tissues See more
Orthologs: human all
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Genomic context

Location:: 17 C; 17 23.99 cM

Exon count:: 18

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	17	NC_000083.7 (48178058..48235401, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	17	NC_000083.6 (47867133..47924632, complement)

Chromosome 17 - NC_000083.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Inhibition of Foxp4 Disrupts Cadherin-based Adhesion of Radial Glial Cells, Leading to Abnormal Differentiation and Migration of Cortical Neurons in Mice.
Title: Inhibition of Foxp4 Disrupts Cadherin-based Adhesion of Radial Glial Cells, Leading to Abnormal Differentiation and Migration of Cortical Neurons in Mice.
Foxp1 and Foxp4 Deletion Causes the Loss of Follicle Stem Cell Niche and Cyclic Hair Shedding by Inducing Inner Bulge Cell Apoptosis.
Title: Foxp1 and Foxp4 Deletion Causes the Loss of Follicle Stem Cell Niche and Cyclic Hair Shedding by Inducing Inner Bulge Cell Apoptosis.
The forkhead box transcription factor FoxP4 regulates thermogenic programs in adipocytes.
Title: The forkhead box transcription factor FoxP4 regulates thermogenic programs in adipocytes.
Combined loss of all three Foxp1/2/4 family members in the developing anterior foregut endoderm leads to a loss of lung endoderm lineage commitment and subsequent development. Foxp1/2/4 deficient lungs express high levels of transcriptional regulators not normally expressed in developing lung. Ectopic expression of these transcriptional regulators is accompanied by decreased expression of lung restricted transcription.
Title: Foxp transcription factors suppress a non-pulmonary gene expression program to permit proper lung development.
Collectively, these findings reveal an important role for the FOXP1, 2, and 4 proteins in governing postnatal alpha cell expansion and function.
Title: The FOXP1, FOXP2 and FOXP4 transcription factors are required for islet alpha cell proliferation and function in mice.
Foxp1/2/4 may regulate Runx2 during endochondral ossification.
Title: Foxp1/2/4 regulate endochondral ossification as a suppresser complex.
Loss of Foxp1/4 in the developing lung and in postnatal secretory epithelium leads to ectopic activation of the goblet cell fate program, in part, through de-repression of the protein disulfide isomerase anterior gradient 2 (Agr2).
Title: Foxp1/4 control epithelial cell fate during lung development and regeneration through regulation of anterior gradient 2.
the data of this study revealed a Foxp-based transcriptional mechanism that regulates the integrity and cytoarchitecture of neuroepithelial progenitors
Title: Foxp-mediated suppression of N-cadherin regulates neuroepithelial character and progenitor maintenance in the CNS.
Foxp4 is dispensable for the early Purkinje cell (PC) dendrite outgrowth but is essential for the maintenance of PC dendritic arborization and subsequent association with Bergmann glial fibers.
Title: Foxp4 is essential in maintenance of Purkinje cell dendritic arborization in the mouse cerebellum.
Foxp1/2/4-NuRD interactions regulate gene expression and epithelial injury response in the lung via regulation of interleukin-6.
Title: Foxp1/2/4-NuRD interactions regulate gene expression and epithelial injury response in the lung via regulation of interleukin-6.

Submit: New GeneRIF Correction See all GeneRIFs (13)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Gene trapped (1)
Targeted (3) 1 citation
Endonuclease-mediated (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

stSG634860 (e-PCR)
- UniSTS:461415

Foxp4 (e-PCR), detects polymorphism
- UniSTS:474727

Foxp4 (e-PCR), detects polymorphism
- UniSTS:536524

RH130703 (e-PCR)
- UniSTS:213987

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables DNA-binding transcription factor activity	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription repressor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables DNA-binding transcription repressor activity, RNA polymerase II-specific	IDA Inferred from Direct Assay more info	PubMed
enables DNA-binding transcription repressor activity, RNA polymerase II-specific	IMP Inferred from Mutant Phenotype more info	PubMed
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IMP Inferred from Mutant Phenotype more info	PubMed
enables identical protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables sequence-specific DNA binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within embryonic foregut morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within heart development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within lung secretory cell differentiation	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within negative regulation of lung goblet cell differentiation	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of lung goblet cell differentiation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: forkhead box protein P4

Names: fork head-related protein like A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001110824.2 → NP_001104294.1 forkhead box protein P4 isoform 1

See identical proteins and their annotated locations for NP_001104294.1

Status: VALIDATED

Source sequence(s)

AC113536, AC164306

Consensus CDS

CCDS50137.1

UniProtKB/TrEMBL

A0A0R4J161, D3Z726

Related

ENSMUSP00000094916.3, ENSMUST00000097311.9

Conserved Domains (3) summary

smart00339
Location:472 → 544

FH; FORKHEAD

COG5025
Location:370 → 565

COG5025; Transcription factor of the Forkhead/HNF3 family [Transcription]

pfam16159
Location:309 → 376

FOXP-CC; FOXP coiled-coil domain
NM_001110825.2 → NP_001104295.1 forkhead box protein P4 isoform 2

See identical proteins and their annotated locations for NP_001104295.1

Status: VALIDATED

Source sequence(s)

AC113536, AC164306

Consensus CDS

CCDS50136.1

UniProtKB/TrEMBL

A0A0R4J1I5, D3Z726

Related

ENSMUSP00000108887.2, ENSMUST00000113262.2

Conserved Domains (2) summary

pfam00250
Location:460 → 539

Forkhead; Forkhead domain

pfam16159
Location:309 → 376

FOXP-CC; FOXP coiled-coil domain
NM_001403969.1 → NP_001390898.1 forkhead box protein P4 isoform 4

Status: VALIDATED

Source sequence(s)

AC113536, AC164306
NM_001403970.1 → NP_001390899.1 forkhead box protein P4 isoform 5

Status: VALIDATED

Source sequence(s)

AC113536, AC164306
NM_028767.3 → NP_083043.2 forkhead box protein P4 isoform 3

See identical proteins and their annotated locations for NP_083043.2

Status: VALIDATED

Source sequence(s)

AC113536, AC164306

Consensus CDS

CCDS50135.1

UniProtKB/TrEMBL

D3Z726

Related

ENSMUSP00000108890.2, ENSMUST00000113265.8

Conserved Domains (2) summary

pfam00250
Location:459 → 538

Forkhead; Forkhead domain

pfam16159
Location:308 → 375

FOXP-CC; FOXP coiled-coil domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000083.7 Reference GRCm39 C57BL/6J

Range

48178058..48235401 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017317686.2 → XP_017173175.1 forkhead box protein P4 isoform X1

UniProtKB/TrEMBL

D3Z726

Conserved Domains (3) summary

smart00339
Location:479 → 551

FH; FORKHEAD

COG5025
Location:375 → 572

COG5025; Transcription factor of the Forkhead/HNF3 family [Transcription]

pfam16159
Location:309 → 376

FOXP-CC; FOXP coiled-coil domain
XM_030250107.1 → XP_030105967.1 forkhead box protein P4 isoform X3

UniProtKB/TrEMBL

A0A0R4J161, D3Z726

Conserved Domains (3) summary

smart00339
Location:472 → 544

FH; FORKHEAD

COG5025
Location:370 → 565

COG5025; Transcription factor of the Forkhead/HNF3 family [Transcription]

pfam16159
Location:309 → 376

FOXP-CC; FOXP coiled-coil domain
XM_017317687.3 → XP_017173176.1 forkhead box protein P4 isoform X1

UniProtKB/TrEMBL

D3Z726

Conserved Domains (3) summary

smart00339
Location:479 → 551

FH; FORKHEAD

COG5025
Location:375 → 572

COG5025; Transcription factor of the Forkhead/HNF3 family [Transcription]

pfam16159
Location:309 → 376

FOXP-CC; FOXP coiled-coil domain