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    Srprb signal recognition particle receptor, B subunit [ Mus musculus (house mouse) ]

    Gene ID: 20818, updated on 9-May-2024

    Summary

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    Official Symbol
    Srprbprovided by MGI
    Official Full Name
    signal recognition particle receptor, B subunitprovided by MGI
    Primary source
    MGI:MGI:102964
    See related
    Ensembl:ENSMUSG00000032553 AllianceGenome:MGI:102964
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Summary
    Predicted to enable ubiquitin protein ligase binding activity. Predicted to be involved in protein targeting to ER. Predicted to be located in cytoplasmic microtubule and membrane. Predicted to be part of signal recognition particle receptor complex. Is expressed in several structures, including bone; brain; cardiovascular system; genitourinary system; and gut. Orthologous to human SRPRB (SRP receptor subunit beta). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in adrenal adult (RPKM 31.7), placenta adult (RPKM 31.4) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Srprb in Genome Data Viewer
    Location:
    9 F1; 9 55.0 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (103065232..103079264, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (103188033..103202065, complement)

    Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E8309 Neighboring gene predicted gene, 46128 Neighboring gene predicted gene, 51658 Neighboring gene RAB6B, member RAS oncogene family Neighboring gene STARR-positive B cell enhancer ABC_E6799 Neighboring gene transferrin Neighboring gene predicted gene, 53542

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. The beta subunit of the signal recognition particle receptor is a transmembrane GTPase that anchors the alpha subunit, a peripheral membrane GTPase, to the endoplasmic reticulum membrane. Miller JD, et al. J Cell Biol, 1995 Feb. PMID 7844142, Free PMC Article
    2. The structure of the mammalian signal recognition particle (SRP) receptor as prototype for the interaction of small GTPases with Longin domains. Schlenker O, et al. J Biol Chem, 2006 Mar 31. PMID 16439358
    3. Different effects of Sec61α, Sec62 and Sec63 depletion on transport of polypeptides into the endoplasmic reticulum of mammalian cells. Lang S, et al. J Cell Sci, 2012 Apr 15. PMID 22375059, Free PMC Article
    4. TRIM27 cooperates with STK38L to inhibit ULK1-mediated autophagy and promote tumorigenesis. Yang Y, et al. EMBO J, 2022 Jul 18. PMID 35670107, Free PMC Article
    5. Vti1b promotes TRPV1 sensitization during inflammatory pain. Sondermann JR, et al. Pain, 2019 Feb. PMID 30335684

    See all (30) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Gene trapped (1) 
    • Targeted (2) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ubiquitin protein ligase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in SRP-dependent cotranslational protein targeting to membrane, signal sequence recognition NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in protein targeting to ER IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasmic microtubule ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    located_in membrane NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    part_of signal recognition particle receptor complex EXP
    Inferred from Experiment
    more info
    		 PubMed 
    part_of signal recognition particle receptor complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of signal recognition particle receptor complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    signal recognition particle receptor subunit beta
    Names
    SR-beta

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_009275.4 → NP_033301.1  signal recognition particle receptor subunit beta

      See identical proteins and their annotated locations for NP_033301.1

      Status: PROVISIONAL

      Source sequence(s)
      AK030437
      Consensus CDS
      CCDS23450.1
      UniProtKB/Swiss-Prot
      P47758, Q544X9, Q9D872
      UniProtKB/TrEMBL
      Q542X6
      Related
      ENSMUSP00000035157.9, ENSMUST00000035157.10
      Conserved Domains (2) summary
      cd04105
      Location:63 → 268
      SR_beta; Signal recognition particle receptor, beta subunit (SR-beta), together with SR-alpha, forms the heterodimeric signal recognition particle (SRP)
      pfam09439
      Location:60 → 239
      SRPRB; Signal recognition particle receptor beta subunit

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000075.7 Reference GRCm39 C57BL/6J

      Range
      103065232..103079264 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P47758.1 GenPept UniProtKB/Swiss-Prot:P47758

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
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